Jack Zakrzewski

ORCID: 0000-0002-9824-8148
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About
Contact & Profiles
Research Areas
  • Spinal Fractures and Fixation Techniques
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Transplantation: Methods and Outcomes
  • Mechanical Circulatory Support Devices
  • Organ Transplantation Techniques and Outcomes
  • COVID-19 Clinical Research Studies
  • Glioma Diagnosis and Treatment
  • Cardiac Ischemia and Reperfusion
  • Cerebrospinal fluid and hydrocephalus
  • Cervical and Thoracic Myelopathy
  • Spine and Intervertebral Disc Pathology
  • COVID-19 and healthcare impacts
  • Neurosurgical Procedures and Complications
  • Mycobacterium research and diagnosis
  • Tuberculosis Research and Epidemiology
  • Bone and Joint Diseases
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Infection Control and Ventilation
  • Adenosine and Purinergic Signaling
  • Neurofibromatosis and Schwannoma Cases
  • Vagus Nerve Stimulation Research
  • Organ Donation and Transplantation
  • Congenital Heart Disease Studies
  • Facial Trauma and Fracture Management
  • Neuroblastoma Research and Treatments

University of Colorado Anschutz Medical Campus
2021-2025

University of Colorado Denver
2023-2025

University of Colorado System
2023

University of Illinois Chicago
2018-2022

Advocate Heart Institute
2022

Advocate Christ Medical Center
2022

St. Mary Medical Center
2019

Natural Pharmacia International (United States)
2018

Abstract Most applications of nanotechnology in cancer have focused on systemic delivery cytotoxic drugs. Systemic relies accumulation nanoparticles a target tissue through enhanced permeability leaky vasculature and retention effect poor lymphatic drainage to increase the therapeutic index. is limited, however, by toxicity difficulty crossing natural obstructions, like blood spine barrier. Magnetic drug targeting (MDT) new technique reach tumors central nervous system. Here, we describe...

10.1038/s41598-018-29736-5 article EN cc-by Scientific Reports 2018-07-24

Autologous bone removed during craniectomy is often the material of choice in cranioplasty procedures. However, when patient's own not appropriate (infection and resorption), an alloplastic graft must be utilized. Common options include titanium mesh polyetheretherketone (PEEK)-based custom flaps. Often, neurosurgeons decide whether to use a or implant, with limited direction from literature.To compare surgical outcomes synthetic cranioplasties performed vs implants.Ten-year retrospective...

10.1093/neuros/nyz358 article EN Neurosurgery 2019-09-06

Patients on left ventricular assist device (LVAD) support may be susceptible to severe disease and complications from coronavirus disease-19 (COVID-19). The purpose of this study was describe the clinical course COVID-19 in LVAD patients. A retrospective review performed at our center; 28 patients who developed between March 2020 2021, six with a prior infection underwent implantation, were identified examined. Of patients, nine (32%) died during period, five (18%) their index...

10.1097/mat.0000000000001578 article EN ASAIO Journal 2021-09-01

Background: Intramedullary spinal cord tumors (IMSCTs) account for 8–10% of all and affect patients ages. Although uncommon, IMSCTs carry risk neurological morbidity mortality, with 5-year survival rates ranging from 50% to 80%. In this study, we utilize the American College Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database determine effect steroid administration on 30-day outcomes following surgery IMSCTs. Methods: ACS-NSQIP data undergoing intramedullary 2005 2015...

10.21037/jss.2018.03.18 article EN Journal of Spine Surgery 2018-03-01

Vertebral compression fractures (VCFs) caused by metastatic malignancies or osteoporosis are devastating injuries with debilitating outcomes for patients. Minimally invasive kyphoplasty is a common procedure used symptomatic amelioration. However, it fails in treating the underlying etiologies of VCFs. Use systemic therapy limited due to low perfusion spinal column and toxicity. Localized delivery drugs vertebral can provide promising alternative approach. A porcine model was developed study...

10.1371/journal.pone.0201402 article EN cc-by PLoS ONE 2018-07-27

Mycobacterium fortuitum is a rare, opportunistic pathogen most frequently contracted through contact with contaminated source. An immunocompetent 26-year-old female patient presented to our institution an infected lumboperitoneal (LP) shunt presenting as continued nonhealing wounds. After multiple debridements, revisions, and wound closure failures, infectious disease specialists were consulted. The cultures returned positive for M. the was removed. Cerebrospinal fluid studies revealed...

10.14423/smj.0000000000000955 article EN Southern Medical Journal 2019-04-01

Background: The influence of home-to-transplantation center travel time as a potential barrier to healthcare accessibility and its impact on clinical outcomes has not been examined following heart transplantation. Hypothesis: Prolonged the transplantation leads worse access healthcare. Aims: Study an exposure variable in Organ Procurement Transplantation Network database. Methods: This is observational study adult transplant recipients who received graft between 2012-2022 United States....

10.1161/circ.148.suppl_1.12965 article EN Circulation 2023-11-07
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