A5004526100- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Sleep and related disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Mobile Health and mHealth Applications
- Frailty in Older Adults
- Cancer survivorship and care
- Genetics, Aging, and Longevity in Model Organisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced MRI Techniques and Applications
- Neurological and metabolic disorders
The University of Texas Health Science Center at San Antonio
2018-2025
Cedars-Sinai Medical Center
2023-2025
Institute for Neurodegenerative Disorders
2019-2024
Boston University
2022-2024
Monash University
2024
The University of Texas Health Science Center at Houston
2021-2023
South Texas Veterans Health Care System
2023
Geriatric Research Education and Clinical Center
2023
University of Zulia
2023
University of North Texas
2023
Loneliness is common, and its prevalence rising. The relationship of loneliness with subsequent dementia the early preclinical course Alzheimer disease related (ADRD) remains unclear. Thus, primary objective this study was to determine association 10-year all-cause risk cognitive neuroanatomic imaging markers ADRD vulnerability.
Midlife vascular disease risk is a strong factor for late-life dementia. Central arterial stiffness, hallmark of aging, associated with accelerated brain aging and cognitive decline. Habitual aerobic exercise an effective lifestyle strategy to reduce central stiffness related lower impairment.To determine the associations among cardiopulmonary fitness, neuropsychological function, cerebral perfusion in sedentary endurance-trained middle-aged adults.Twenty-six 32 adults were measured maximal...
Abstract Cellular senescence has been identified as a pathological mechanism linked to tau and amyloid beta (Aβ) accumulation in mouse models of Alzheimer's disease (AD). Clearance senescent cells using the senolytic compounds dasatinib (D) quercetin (Q) reduced neuropathological burden improved clinically relevant outcomes mice. Herein, we conducted vanguard open-label clinical trial therapy for AD with primary aim evaluating central nervous system (CNS) penetrance, well exploratory data...
ABSTRACT Background and hypothesis It remains unclear whether the relation of chronic kidney disease (CKD) with cognitive dysfunction is independent blood pressure (BP). We evaluated function in to premorbid BP measurements, cerebral small vessel (CSVD), incident mild impairment (MCI) dementia Framingham Offspring Cohort participants. Methods included participants free dementia, attending an examination during midlife (exam cycle 6, baseline) for ascertainment status, brain magnetic...
Midlife obesity is associated with cognitive deficits and cerebral atrophy in older age. However, little known about the early signs of these deleterious brain effects or physiological mechanisms that underlie them. Functional magnetic resonance imaging (fMRI) allows us to detect changes response challenges while behavioral performance still intact. Accordingly, we examined impact on functional activation during a 2-Back task 32 cognitively normal middle-aged adults, who were classified into...
The Functional Activities Questionnaire (FAQ) is a collateral-report measure of difficulties in activities daily living. Despite its widespread use, psychometric analyses have been limited scope, piecemeal across samples, and primarily to classical test theory. This article consolidated expanded using tools from generalizability item response theories among 27,916 individuals the National Alzheimer's Coordinating Center database who completed FAQ. Reliability was evaluated with internal...
Abstract Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body (LBD), limbic-predominant age-related TDP-43 encephalopathy (LATE-NC), and cerebrovascular (CVD) frequently coexist, but little is known about the exact contribution of each pathology to cognitive decline dementia in subjects with mixed pathologies. We explored relative impact concurrent common rare neurodegenerative employing multivariate logistic regression analysis adjusted for age,...
Children with ADHD lack self-awareness of their social and academic deficits, frequently rating themselves more favorably than external sources. The purpose the current study was to assess whether adolescents also hold a positive bias toward executive functioning (EF).Participants include 22 control 35 subjects, aged 11 16. Participants parents completed Behavior Rating Inventory Executive Functioning (BRIEF) Self Parent forms, respectively. Discrepancy scores were calculated for each domain...
Aging | doi:10.18632/aging.203918. Yinan Zheng, Mohamad Habes, Mitzi Gonzales, Raymond Pomponio, Ilya Nasrallah, Sadiya Khan, Douglas E. Vaughan, Christos Davatzikos, Sudha Seshadri, Lenore Launer, Farzaneh Sorond, Sanaz Sedaghat, Derek Wainwright, Andrea Baccarelli, Stephen Sidney, Nick Bryan, Philip Greenland, Donald Lloyd-Jones, Kristine Yaffe, Lifang Hou
Midlife vascular disease risk is associated with higher incidence of cognitive impairment in late life. Regular aerobic exercise improves function, which turn may translate into better function. The purpose this study was to determine the associations among cardiorespiratory fitness, cerebral and peripheral reactivity, function sedentary endurance-trained middle-age adults.Thirty-two 27 healthy participants ages 43-65 yr underwent measurements maximal oxygen uptake (VO2max), neurocognitive...
Plasma phosphorylated-tau181 (p-tau181) is a promising biomarker for Alzheimer's disease (AD) and may offer utility predicting preclinical disease.
<title>Abstract</title> Senescent cell accumulation contributes to the progression of age-related disorders including Alzheimer’s disease (AD). Clinical trials evaluating senolytics, drugs that clear senescent cells, are underway, but lack standardized outcome measures. Our team recently published data from first open-label trial evaluate senolytics (dasatinib plus quercetin) in AD. After 12-weeks intermittent treatment, we reported brain exposure dasatinib, favorable safety and...
Trajectories following a diagnosis of mild cognitive impairment (MCI) are varied and may fluctuate over time. Among diverse ethnic racial groups, social factors, medical comorbidities, biases in assessment procedures contribute to greater heterogeneity the MCI diagnostic category affect its prognostic significance for dementia. The study goal was evaluate frequency variables associated with transitions among non-Hispanic White (NHW) Latinx older adults. Multistate Markov models characterized...
<title>Abstract</title> Rapamycin, known for its anti-aging properties, shows promise as a preventive strategy Alzheimer’s disease (AD) in APOE4 carriers—the highest-risk group late-onset AD. Here we show that 4-week open-label trial of low-dose Rapamycin (Sirolimus; 1 mg/day) significantly improved cerebral blood flow (CBF) relative to baseline cognitively normal carriers (E4(+)) aged 45–65. It also reduced inflammatory cytokines, enhanced lipid metabolism, increased short-chain fatty acids...
List-learning tasks are important for characterizing memory in ADRD research, but the Uniform Data Set neuropsychological battery (UDS-NB) lacks a list-learning paradigm; thus, sites administer range of tests. We developed harmonized composite that incorporates UDS tests and multiple tasks. Item-banking confirmatory factor analysis was applied to develop diagnostically heterogenous sample (n=5943) who completed UDS-NB one five Construct validity evaluated through associations with...