A5011937215- Vitamin D Research Studies
- Asthma and respiratory diseases
- Multiple Sclerosis Research Studies
- Stress Responses and Cortisol
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Peripheral Neuropathies and Disorders
- Vitamin C and Antioxidants Research
- Monoclonal and Polyclonal Antibodies Research
- Circadian rhythm and melatonin
- GDF15 and Related Biomarkers
- Digestive system and related health
- Genetic factors in colorectal cancer
- Salivary Gland Disorders and Functions
- Immunodeficiency and Autoimmune Disorders
- Allergic Rhinitis and Sensitization
- Adrenal Hormones and Disorders
- Pharmaceutical studies and practices
- Liver Disease Diagnosis and Treatment
- Acne and Rosacea Treatments and Effects
- Single-cell and spatial transcriptomics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pregnancy and Medication Impact
- Diabetes Treatment and Management
- Infant Nutrition and Health
The Kids Research Institute Australia
2017-2022
The University of Western Australia
2011-2022
There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based on immunoregulatory properties and epidemiological studies. The aim of this study was to investigate the association between exposure utero allergic outcomes first year life.Cord blood (CB) measured 231 high-risk infants from an Australian prospective birth cohort. CB 25-hydroxyvitamin D(3) (25[OH]D(3)) concentration analyzed relation maternal intake infant eczema, allergen...
Altered composition of gut bacteria and changes to the production their bioactive metabolites, short-chain fatty acids (SCFAs), have been implicated in development multiple sclerosis (MS). However, immunomodulatory actions SCFAs intermediaries ability influence MS pathogenesis are uncertain. In this study, levels serum were correlated with immune cell abundance phenotype as well other relevant factors blood samples taken at first presentation Clinically Isolated Syndrome (CIS; an early form...
Background The natural history of multiple sclerosis (MS) typically presents with the clinically isolated syndrome (CIS), an episode neurological symptoms caused by central nervous system inflammation or demyelination that does not fulfil diagnostic criteria for MS. Objective As preclinical studies have suggested exposure to ultraviolet radiation (UVR) could regulate development MS, Phototherapy CIS (PhoCIS trial) was established examine effects narrowband UVB phototherapy on patients CIS,...
Clinically isolated syndrome (CIS) is a first episode of neurological symptoms that may precede diagnosis multiple sclerosis (MS). Therefore, studying individuals with CIS lead to breakthroughs in understanding the development and pathogenesis MS. In this study, serum levels immunoglobulin (Ig)G, IgA, IgM, IgG1–4 were measured 20 people compared those 10 healthy controls (HC) 8 Serum Ig a) time their conversion from MS, b) antibodies Epstein-Barr virus (EBV), c) frequencies T regulatory...
Abstract Objectives Disease‐modifying therapies (DMTs) targeting B cells are amongst the most effective for preventing multiple sclerosis (MS) progression. IgG 3 antibodies and their uncharacterised B‐cell clones predicted to play a pathogenic role in MS. Identifying subsets of + involved MS progression could improve diagnosis, inform timely disease intervention may lead new DMTs that target more specifically. Methods We designed 31‐parameter B‐cell‐focused mass cytometry panel interrogate...
Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment-naive individuals with recently diagnosed (<120 days) for the phenotype T regulatory (Treg), follicular (Tfr), helper (Th), (Tfh) and B cells. Relative healthy controls (n=19), was...
Abstract Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation implicated risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression MS people with CIS. Twenty individuals CIS were recruited, half randomised receive 24 sessions over a period 8 weeks. Here, effects on frequencies circulating immune cells immunoglobulin levels after are reported. Peripheral blood samples for all...
Lower vitamin D status at birth and during infancy has been associated with increased incidence of eczema food allergies. The aim this study was to investigate the effect early supplementation on allergic disease outcomes in infants “hereditary risk” disease, but who had sufficient levels birth. Here, we report childhood follow-up 2.5 years age “high-risk” participated a double-blinded, randomized controlled trial. For inclusion trial, late gestation (36–40 weeks) maternal 25-hydroxyvitamin...
The dramatic rise in allergic disease has occurred tandem with recent environmental changes and increasing indoor lifestyle culture. While multifactorial, one consistent allergy risk factor been reduced sunlight exposure. However, vitamin D supplementation studies have disappointing preventing allergy, raising possible independent effects of ultraviolet (UV) light aim this study was to examine whether UV exposure influences the development early childhood. Direct (290–380 nm) infancy...
It is not clear how the profile of immune cells in peripheral blood differs between patients with clinically isolated syndrome (CIS) and healthy controls (HC). This study aimed to identify a CIS signature that may provide clues for potential immunomodulatory approaches early disease. Peripheral mononuclear (PBMCs) were collected from 18 people CIS, 19 HC 13 individuals other demyelinating conditions (ODC) including multiple sclerosis (MS). Individuals separated into two groups, namely those...
To determine whether serum neurofilament light chain (sNfL) levels are suppressed in patients with the clinically isolated syndrome (CIS) following narrowband ultraviolet B phototherapy (UVB-PT).sNfL were measured using a sensitive single-molecule array assay at baseline and up to 12 months 17 CIS, 10 of whom received UVB-PT, compared healthy control (HC) early relapsing remitting multiple sclerosis (RRMS) group. sNfL correlated magnetic resonance imaging total lesion volume (LV) determined...
Hypovitaminosis D is prevalent worldwide; however, analytical bias in the measurement of circulating 25-hydroxyvitamin (25(OH)D) concentrations may affect clinical treatment decisions and research. We performed parallel plasma 25(OH)D analyses using Abbott Architect i2000 chemiluminescent immunoassay (CIA) liquid chromatography–tandem mass spectrometry (LC–MS/MS) for paired samples from same infants at 3 (n = 69), 6 79) 12 months 73) age. To test agreement, we used Lin’s concordance...
This article was originally published online on 23 April 2013 There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based immunoregulatory properties and epidemiological studies. The aim of this study to investigate the association between exposure utero allergic outcomes first year life. Cord blood (CB) measured 231 high risk infants from an Australian prospective birth cohort. CB 25(OH)D3 concentration analysed relation maternal intake...
Given the current interest in vitamin D status and its suggested relationship to immune metabolic outcomes, accurate reliable assessment of 25(OH)D concentrations both research clinical settings is imperative. CIA routinely used most laboratories whereas LC-MS/MS defined as gold standard. However, studies adults have been performed detecting substantial variation measured 25(OH)D3 levels comparing methods. We are currently conducting first RCT on infancy allergic outcome early childhood....