A5101468043- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- interferon and immune responses
- Renal Diseases and Glomerulopathies
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Adolescent and Pediatric Healthcare
- Gout, Hyperuricemia, Uric Acid
- Orthopedic Infections and Treatments
- Platelet Disorders and Treatments
- Kawasaki Disease and Coronary Complications
- Dialysis and Renal Disease Management
- Osteomyelitis and Bone Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Myopathies and Dermatomyositis
- Sarcoidosis and Beryllium Toxicity Research
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- Complement system in diseases
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Rheumatoid Arthritis Research and Therapies
- Hematological disorders and diagnostics
- Phagocytosis and Immune Regulation
Sağlık Bilimleri Üniversitesi
2017-2025
Ümraniye Eğitim ve Araştırma Hastanesi
2017-2025
Universidad CES
2024
Erciyes University
2014-2023
University of Health Science
2023
Hacettepe University
2017-2023
Pediatrics and Genetics
2023
Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi
2022
University Hospital Centre Zagreb
2021
University of Health Sciences
2019
Urinary bladder malformations associated with outlet obstruction are a frequent cause of progressive renal failure in children. We here describe muscarinic acetylcholine receptor M3 (CHRM3) (1q41-q44) homozygous frameshift mutation familial congenital malformation prune-belly-like syndrome, defining an isolated gene defect underlying this sometimes devastating disease. CHRM3 encodes the receptor, which we show is present developing epithelia and muscle. These observations may imply that has...
Abstract Introduction Therapeutic plasma exchange (TPE) is crucial for saving lives when used appropriately. This study aimed to assess TPE's impact on tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) protein and IL‐6 levels in critically ill pediatric patients. Methods Conducted between May 2022 December 2022, the observed intensive care unit (PICU) patients undergoing TPE, recording demographics, lab results, TWEAK, pre‐ post‐procedure. Results Of 41 patients, 53.7% were male,...
ABSTRACT Aim In this study, we aimed to evaluate and compare the characteristics of pediatric adult rhupus patients. Methods Thirty patients with syndrome 15 were included in study. Similarities differences between both groups evaluated. Results The time elapsed diagnosis juvenile idiopathic arthritis (JIA)/rheumatoid (RA) systemic lupus erythematosus (SLE) was longer adults than ( p < 0.001). While most common phenotypes at disease onset JIA/RA children, SLE more prevalent RA last visit...
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of and serositis. Patients may develop renal amyloidosis. Colchicine prevents Five to 10 % the patients with FMF are resistant or intolerant colchicine. Herein, we reported our experience clinical-laboratory features treatment responses a pediatric patient amyloidosis treated canakinumab. We observed significant decrease in proteinuria increase growth patient. The most serious...
In this study, we examined the efficacy and safety of a once-daily dosage schema colchicine compared with twice-daily in pediatric patients familial Mediterranean fever (FMF). 24-week, multicenter, randomized controlled noninferiority trial, newly diagnosed FMF carrying homozygous or compound heterozygous mutation not receiving any treatment were included. Patients randomly assigned using block randomization method to receive once- dosage. Clinical laboratory characteristics medication side...
The effectiveness of assessing volume load via bioimpedance in pediatric patients with nephrotic syndrome (NS) was investigated.Patients NS (n = 34) were compared healthy controls 20). inferior vena cava index and collapsibility (IVCCI) scores determined for all subjects. Bioimpedance measurements used to directly determine load. Clinical findings, relative fluid load, echocardiographic calculating load.The sensitivity specificity determining found be 65% 90%, respectively. IVCCI lower than...
In this study, we present our clinical severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) experience in patients with childhood rheumatic disease during novel coronavirus-2019 (COVID-19) pandemic.A total of 87 (50 males, 37 females; median age: 12 years; range, 6.6 to 16 years) suspected having COVID-19 at pediatric rheumatology clinic between March 11th and October 15th 2020 were retrospectively analyzed. Demographic features, treatments, laboratory results, imaging findings,...
Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder characterized by episodes of inflammation in the absence high-titer autoantibodies or antigen-specific T cells. The (MEFV) gene located on chromosome 16p13.3, which encodes 781–amino-acid protein pyrin, causative for this monogenic Mendelian disease. This study presents molecular analysis an MEFV mutation screen 5518 Turkish individuals with clinical diagnoses FMF. Patients were genetically diagnosed using FMF...
Background/aim: Familial Mediterranean fever (FMF) is diagnosed by episodes with sterile peritonitis, arthritis, pleurisy, and erysipelas-like erythema. The relationship between phenotype genotype in FMF has not been adequately explained. aim of this study was to characterize the correlation FMF. Materials methods: Clinical diagnosis conducted according Tel Hashomer criteria. Pras scoring used determine clinical severity. strip assay analysis used, hotspot regions were observed PCR...
Because of the immature bone marrow signal in children, assessment sacroiliac joint is more difficult than adults. Aim this study to evaluate efficacy diffusion-weighted imaging (DWI) magnetic resonance (MRI).Sacroiliac MRI, including DWI sequences, were evaluated by two pediatric radiologists 54 patients with sacroiliitis and 85 completely normal controls. In MRI evaluation, subchondral edema contrast enhancement joints considered as active sacroiliitis. Apparent diffusion coefficient (ADC)...