A5045364229- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Adolescent and Pediatric Healthcare
- Kawasaki Disease and Coronary Complications
- Immunodeficiency and Autoimmune Disorders
- Infectious Diseases and Tuberculosis
- Inflammatory Biomarkers in Disease Prognosis
- Vasculitis and related conditions
- Inflammatory Myopathies and Dermatomyositis
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Spondyloarthritis Studies and Treatments
- IL-33, ST2, and ILC Pathways
- Neurogenetic and Muscular Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- Vitamin D Research Studies
- Gout, Hyperuricemia, Uric Acid
- Childhood Cancer Survivors' Quality of Life
- Streptococcal Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Venous Thromboembolism Diagnosis and Management
- Osteomyelitis and Bone Disorders Research
- Hematological disorders and diagnostics
- Cardiovascular Disease and Adiposity
- Cultural and Sociopolitical Studies
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2017-2024
Dokuz Eylül University
2014-2024
Children's Hospital
2024
University of Health Science
2023
Center for Rheumatology
2017-2023
Istanbul University
2023
Sağlık Bilimleri Üniversitesi
2023
Universidad CES
2022
Hacettepe University Hospital
2015
Turkish Armed Forces
2014
Familial Mediterranean Fever (FMF) is an autosomal recessive genetic disorder, primarily observed in populations around the Sea, linked to MEFV gene mutations. These mutations disrupt inflammatory responses, increasing pyrin-protein production. Traditional diagnosis relies on clinical symptoms, family history, acute phase reactants, and excluding similar syndromes with testing, which expensive often inconclusive due heterozygous Here, we present a biosensor platform that detects differences...
Macrophage activation syndrome (MAS) is a severe, potentially fatal complication of childhood rheumatic diseases, especially systemic onset juvenile idiopathic arthritis (SoJIA). We report 4-year-old girl with probable SoJIA who presented MAS. She did not respond to pulse methyl prednisolone and Cyclosporine A (CsA). also failed intravenous immunoglobulin (IVIG) therapy. Etanercept was started, based on the observation increased serum levels tumor necrosis factor-alpha (TNF-alpha) in...
Background: Nonalcoholic fatty liver disease (NAFLD) is the accumulation of excess fat in absence alcohol consumption, which commonly coexists with obesity. NAFLD associated increased risk atherosclerosis and insulin resistance Mean platelet volume (MPV) a marker activation, determinant atherosclerosis.
This study aimed to investigate sleep patterns, disturbances and possible factors that are associated with among children familial Mediterranean fever (FMF).Fifty-one patients FMF 84 age- sex-matched healthy controls were enrolled in the study. The who had an attack during last 2 weeks not included. Demographic data, symptoms, disease duration, dose of colchicine, severity score, number attacks year, MEFV mutation serum C-reactive protein (CRP) levels recorded for each patient. A Children's...
Background: Little is known about the long-term efficacy and safety of canakinumab in paediatric FMF patients.Aim: To present single centre experience colchicine-resistant paediatric-onset patients who were treated with by off-label use since 2012.Methods: The hospital files 15 children used retrospectively evaluated. Clinical laboratory data each visit recorded. Drug-related adverse events Complete remission was described as no attacks normal acute phase reactants; partial defined decrease...
The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report results cross-cultural adaptation and validation parent patient versions JAMAR Turkish language. reading comprehension questionnaire was tested 10 JIA parents patients. Each participating centre asked to collect demographic, clinical data 100 consecutive...
Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between oxidative and inflammatory cytokines investigate how melatonin affects damage cytokine response thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served negative controls. B had untreated thyrotoxicosis, C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), reductase (GR), peroxidase (GPx), nitric oxide derivates (NO*x), plasma...
In this study, we examined the efficacy and safety of a once-daily dosage schema colchicine compared with twice-daily in pediatric patients familial Mediterranean fever (FMF). 24-week, multicenter, randomized controlled noninferiority trial, newly diagnosed FMF carrying homozygous or compound heterozygous mutation not receiving any treatment were included. Patients randomly assigned using block randomization method to receive once- dosage. Clinical laboratory characteristics medication side...
To develop and test a hybrid measure of muscle strength for juvenile dermatomyositis (JDM), which is based on the combination Manual Muscle Testing in 8 muscles (MMT-8) Childhood Myositis Assessment Scale (CMAS) but more comprehensive than former feasible latter.The MMT-8/CMAS (hMC) composed all items MMT-8 3 CMAS: time head lift, assessment abdominal muscles, floor rise. The score ranges 0-100, with 100 indicating normal strength. Validation procedures were conducted using large...
This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population obese adolescents.Sixty-eight patients 23 controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein low-density alanine aminotransferase, aspartate γ-glutamyl transpeptidase, hemoglobin, white blood cell count, MPV insulin resistance by homeostasis model assessment investigated. Furthermore, CCA was measured...
This study was undertaken to investigate the effects of early parenteral nutrition on prevention neonatal jaundice in term and near-term neonates who could not be enterally fed.Seventy-two infants were randomized into 2 groups: group (group 1) received 1.0 g/kg/d amino acids beginning within first day lipid added next day. The conventional 2) started a solution containing 10% glucose electrolytes 72 hours life, followed by 0.5 lipid. Amino each increased maximum 3.0 both groups. Main outcome...