A5093719425- Inflammatory Biomarkers in Disease Prognosis
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Autoimmune and Inflammatory Disorders Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac tumors and thrombi
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- PI3K/AKT/mTOR signaling in cancer
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Testicular diseases and treatments
- Melanoma and MAPK Pathways
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug-Induced Adverse Reactions
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
Ege University
2021-2025
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2024
Sağlık Bilimleri Üniversitesi
2024
Background/Objectives: There is an unmet need to improve outcomes in patients with metastatic Ewing sarcoma (ES). This retrospective, multicenter study aimed evaluate the efficacy and safety of topotecan–cyclophosphamide (TC) regimen adult ES who had previously been treated chemotherapy. Methods: enrolled 75 were at five oncology centers Turkey between 2011 2020. Patients TC regimen, consisting topotecan 0.75 mg/m2/day cyclophosphamide 250 mg/m2/day, given daily for 5 days repeated every 21...
Background and Objectives: ROS1 rearrangement is a rare but targetable alteration in non-small-cell lung cancer (NSCLC), occurring 1–2% of cases. Crizotinib, tyrosine kinase inhibitor, has demonstrated efficacy clinical trials, real-world data remain limited. This study evaluates the safety crizotinib ROS1-rearranged NSCLC patients setting. Materials Methods: multicenter, retrospective research included 43 individuals with advanced/metastatic confirmed rearrangements. Patients were treated...
Background/Objectives: Nivolumab has been shown to be an effective treatment for metastatic renal cell carcinoma (mRCC); however, patient responses vary considerably. The objective of this study is evaluate the prognostic value C-PLAN index in predicting survival outcomes patients with mRCC treated nivolumab. Methods: This retrospective cohort included 81 previously tyrosine kinase inhibitors who subsequently received index, which includes C-reactive protein, performance status, lactate...
Abstract Neoadjuvant chemotherapy (NACT) is the standard treatment for locally advanced, high-risk breast cancer. Pathological complete response (pCR) improves survival. Peripheral blood-derived indices reflecting systemic inflammation and nutritional status have long been used as predictive prognostic markers in solid malignancies. This retrospective study investigates whether eight commonly patients receiving NACT affect pCR includes 624 advanced cancer who received NACT. The biomarker...
Neoadjuvant chemotherapy (NAC) is extensively employed in breast cancer (BC), primarily for aggressive subtypes like triple-negative and human epidermal growth factor receptor 2 (HER2)-positive BC estrogen receptor-positive (ER+)/HER2- with high-risk features. In ER+/HER2- BC, pathological complete rates are much lower (<10%), while axillary dissection higher. This study focuses on hormone (HR+)/HER2- patients undergoing NAC, examining its impact response (pCR) rates, specific attention...
In the REGOMA trial, regorafenib demonstrated an overall survival advantage over lomustine, and it has become a recommended treatment for recurrent glioblastoma in guidelines. This study aimed to evaluate effectiveness safety of as third-line patients with who progressed while taking bevacizumab-based therapy. retrospective, multicenter Turkey included 65 treated between 2021 2023 across 19 oncology centers. The main inclusion criteria were histologically confirmed isocitrate dehydrogenase...
Abstract Objective: Neoadjuvant chemotherapy (NACT) is the standard treatment for locally advanced, high-risk breast cancer. Pathological complete response (pCR) improves survival. Peripheral blood-derived indices reflecting systemic inflammation and nutritional status have long been used as predictive prognostic markers in solid malignancies. This retrospective study investigates whether eight commonly patients receiving NACT effect on pCR Methods: includes 624 with advanced cancer who...
<title>Abstract</title> <bold>Introduction:</bold> Kidney cancer is an immunogenic tumor and inflammation plays a role in formation progression. The aim of this study was to investigate the effect biochemical markers predicting treatment response patients with metastatic renal cell carcinoma (RCC) receiving nivolumab treatment. <bold>Method:</bold> Patients aged ≥18 years who received for RCC between February 2022 January 2024 were evaluated. Cellular blood count evaluated at diagnosis...
Sepsis is one of the leading causes mortality in intensive care units. Its increases, 
 especially with high number comorbidities and immunosuppression. Hemophagocytic syndrome an uncontrolled cytokine storm that develops course increased inflammatory conditions such as sepsis. The clinical picture very wide; because nonspecific symptoms. For this reason; to diagnose hemophagocytic syndrome, it must be kept mind. Mortality patients. Drug reaction eosinophilia systemic symptoms a rare,...