A5060396367- Metastasis and carcinoma case studies
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Myasthenia Gravis and Thymoma
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- PI3K/AKT/mTOR signaling in cancer
- Cervical Cancer and HPV Research
- Breast Lesions and Carcinomas
Dünyagöz Hospital
2021-2025
Istanbul University
2018-2024
Nutrition 21 (United States)
2024
Istanbul Florence Nightingale Hospital
2023-2024
Nightingale Hospital
2023
Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi
2023
City Hospital
2021-2022
Istanbul Medeniyet University
2021
Eskişehir City Hospital
2021
Npistanbul Brain Hospital
2021
Background: In recent years, reducing adjuvant treatment period from 6 months to 3 in low‐risk stage colon cancer has shown no decline efficiency and fewer adverse effects, particularly neuropathy. Aim: We examined the efficacy side effects of 3‐ 6‐month chemotherapy regimens patients. Methods: Twelve oncology centers retrospectively scanned operated, low‐risk, (T1‐3, N1) Capecitabine oxaliplatin (CAPOX) were given all 3‐month patients, while patients received FOLFOX orCAPOX. Two groups...
Studies on PD-L1 expression in breast cancer have gained importance recent years, especially triple-negative (TNBC). Our aim was to analyze the differential of explore its correlation with response neoadjuvant chemotherapy (NACT) and patient survival.PD-L1 evaluated immunohistochemically (Ventana SP263 clone kit) by staining tumor specimen. positivity defined as membranous > 1%, 5%, 10%, 20% either cell (TC) /or immune (IC).Fifty patients locally advanced TNBC, who had a partial NACT, were...
Abstract Aim Endometrial cancer is the most common of female reproductive tract in developed countries. There are many risk factors defined for development endometrial cancer, including obesity. We aimed to evaluate significance adiposity on survival outcomes patients with cancer. Methods The diagnosed and underwent surgery between April 2009 October 2017 were retrospectively reviewed. visceral adipose tissue subcutaneous volumes measured at level umbilicus single‐slice magnetic resonance...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
Background Metastatic and unresectable thymoma (T) or thymic carcinoma (TC) have limited treatment options, especially after first line. Methods Patients with recurrent tumors who used minimum one dose of nivolumab at any line were evaluated retrospectively. Even though was administered 3mg/kg dosage in PRIMER study, due to toxicity financial concerns, we low regimen mostly. Results Among 46 epithelial tumors; 8 patients TC (n = 3), T 4) mixt histology 1) reviewed. Three had myasthenia...
Surgery remains a priority for breast cancer treatment. This study aimed to compare the cosmetic outcomes of oncoplastic patients who had undergone breast-conserving surgery, mini-LDF (latissimus dorsi flap), and immediate implant reconstruction using both Japanese scale BCCT.core (The Breast Cancer Conservative Treatment results software) program validate this program.
The aim of this study is to evaluate the efficacy and toxicity trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) different lines treatment.Retrospective analysis T-DM1 results human epidermal growth factor receptor 2 (Her2) positive 414 mBC from 31 centers Turkey.Except 2, all were female a median age 47. had been used as second-line therapy 37.7% number cycles was 9. Progression-free survival (PFS) overall (OS) times according line treatment. OS found 43, 41, 46, 23...
The aim of this study was to determine the clinicopathological characteristics, treatment details and outcome patients with brain metastasis from epithelial ovarian carcinoma (EOC).This included 21 diagnosed EOC between 1999 2009.Median age 61 years (range 38-77). median time elapsed diagnosis detection 32 months. Single metastases were found in 10 (48%) cases, there extra-cranial disease 11 (52%) cases. During mean 86 months follow-up, 18 (86%) died 3 (14%) alive disease. survival after...
Background The possible impact of malnutrition on the efficacy and tolerability modern chemotherapy for metastatic gastic adenocarcinoma (mGC) patients is unclear. With this study, we aimed to represent chemotherapy, also overall survival mGC patients. Methods In prospective multicenter collected demographic, oncological nutritional data our status were assessed with Nutritional Risk Index (NRI), Body Mass (BMI) weight loss percentage within 21-day period, between cycles. All these...
The optimal number of neoadjuvant chemotherapy (NACT) cycles is unclear in epithelial ovarian cancer. Our study aimed to evaluate the effect NACT before interval debulking surgery on survival.Data 221 patients with advanced-stage serous cancer (EOC) were retrospectively evaluated. divided into groups as who received 3 (group A), 4-5 B), and 6 C).There 67 (30%) group A, 70 (32%) B, 84 (38%) C. Median overall survival (OS) was 61 (range 43-79) months for 44 36-52) 39 27-50) In addition, median...
<b><i>Background and Objectives:</i></b> Inflammatory breast cancer (IBC) is a rare aggressive treated up-front with systemic treatment. Both breast-conserving surgery sentinel lymph node biopsy (SLNB) are controversial issues in the management of IBC. In this study, we aimed to assess feasibility SLNB pathologically proven node-positive IBC patients. <b><i>Methods:</i></b> All patients histopathological diagnosis biopsy-proven metastatic...
Epithelial Ovarian cancer (EOC) is the most lethal gynecologic worldwide. Carboplatin (CP) main chemotherapeutic agent in treatment of ovarian cancer. However, development a hypersensitivity reaction (HSR) 10% to 15% patients with EOC an important limiting factor for clinical use CP. Herein, we aimed investigate efficacy and safety CP-desensitization (CP-D) therapy recurrent EOC. Forty-seven cases treated at Istanbul University Oncology Institute were retrospectively analyzed between...
Objective Fear of cancer recurrence (FCR) is an important psychological trauma associated with reduction in the quality life, disruptions level adjustment, emotional distress and anxiety. The purpose study was to evaluate impact patient–physician relationship on FCR. Methods designed as a multicentre survey study. survivors, who were under remission, evaluated structured questionnaires. Patient–physician (PPR) scale which higher scores indicate better FCR inventory used. Results Between...
Ado-trastuzumab emtansine (T-DM1) is an antibody-drug conjugate and its survival advantage has been shown in advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, clinical trials underrepresent patients ⩾65 years of age, leading to a lack information this population. We analyzed the real-world outcomes older women who were treated with T-DM1 therapy.We performed multicenter, observational, retrospective analysis aged T-DM1. A total 93 from 10 cancer...
<b><i>Introduction:</i></b> Pulmonary sarcomatoid carcinoma (PSC) is a very rare subtype of non-small-cell lung cancer (NSCLC). It frequently diagnosed in the advanced stage and resistant to conventional chemotherapeutics. Due unique nature rarity, we evaluated epidemiological, clinicopathological, survival data PSC patients treated at our centre. <b><i>Patients Methods:</i></b> We retrospectively collected demographic clinical 67 from single...
Aims: In this multicenter study, the authors aimed to determine real-life efficacy and safety of first-line alectinib. Materials & methods: This retrospective trial included advanced-stage, ALK-positive non-small-cell lung cancer patients who were treated with alectinib in terms ALK-tyrosine kinase inhibitors, regardless previous chemotherapy. The co-primary end points progression-free survival both for all treatment-naive population. secondary overall response rate, survival, rate CNS...
Purpose: The aim of the study was to investigate effects body mass index (BMI) on response neoadjuvant chemotherapy (NACT) in Turkish patients with local and locally advanced breast cancer. Methods: pathological responses for axilla were assessed according Miller-Payne grading (MPG) system. Tumors grouped into molecular phenotypes classified as rates MPG system after completion NACT. A 90% or greater reduction tumor cellularity considered a good treatment. Additionally, BMI <25 (group A)...
The study is aimed to determine the relationship between delivery and breastfeeding history of patients andthe clinicopathological properties breast cancer.Materials methods: A questionnaire was utilized for study, which included age diagnosis, number children at thetime children, period each child.Results: 828 patients. median diagnosis 47 years parous women 42 nonparouswomen (p < 0.001). tumor size diagnosed within significantly larger compared theother Estrogen progesterone receptor...
<title>Abstract</title> Background Denosumab, a RANK-ligand inhibitor, is an effectivetreatmentforfor bone metastasesfromsolidtumors.Unlikethebisphosphonates, it not excretedbythekidney. Little known, however, aboutitsefficacyandsafety in patientswith severe chronickidneydisease (CKD). Methods This study retrospective observational and was conducted as multicenter within the scope of Turkish Oncology Group (TOG) project. Patients with breast, prostate lung cancer who received denosumab...
Background Transcription factor E3 (TFE3) related renal cell carcinomas constitute a very small percent of all tumors in adults. Prognosis mainly depends on the stage disease at time diagnosis which is often poor. There yet to be standardized treatment protocol. Treatment options include agents identical TFE3(–) carcinoma treatment. We present case young woman with rapidly progressing metastatic TFE3 (+) carcinoma. Case report A 31 year old female presented abdominal mass, distension,...