Melih Şimşek

ORCID: 0000-0003-0633-8558
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Gastric Cancer Management and Outcomes
  • Metastasis and carcinoma case studies
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Advanced Breast Cancer Therapies
  • Neuroendocrine Tumor Research Advances
  • Lymphoma Diagnosis and Treatment
  • Breast Cancer Treatment Studies
  • Peptidase Inhibition and Analysis
  • Parkinson's Disease and Spinal Disorders
  • Cancer Diagnosis and Treatment
  • Colorectal Cancer Treatments and Studies
  • Nutrition and Health in Aging
  • Inflammatory Biomarkers in Disease Prognosis
  • COVID-19 and healthcare impacts
  • Glioma Diagnosis and Treatment
  • Lung Cancer Treatments and Mutations
  • Childhood Cancer Survivors' Quality of Life
  • Myasthenia Gravis and Thymoma
  • Linguistics and Cultural Studies
  • COVID-19 Clinical Research Studies
  • Multiple Myeloma Research and Treatments
  • Cancer Immunotherapy and Biomarkers
  • Viral-associated cancers and disorders
  • Occupational and environmental lung diseases
  • Coding theory and cryptography

Bezmiâlem Vakıf Üniversitesi
2021-2025

Erzurum Regional Training and Research Hospital
2022

State Hospital
2022

Atatürk University
2015-2021

Dünyagöz Hospital
2019-2021

Kocaeli Üniversitesi
2011-2014

Geriatric syndromes may be more common in older cancer patients than those without cancer. can cause poor clinical outcomes. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is often used as a clinically reported functional status score oncology practice.

10.3389/fmed.2024.1331246 article EN cc-by Frontiers in Medicine 2024-02-19

Background: Osteosarcoma is a rare but aggressive bone malignancy. Despite advances in multimodal therapy, survival remains suboptimal, highlighting the need for prognostic markers to guide treatment. Methods: This study included 162 osteosarcoma patients who received neoadjuvant chemotherapy followed by surgery between January 2009 and March 2024. Patients either double (cisplatin + doxorubicin) or triple (MAP PEI) chemotherapy. Survival analyses were conducted using Kaplan–Meier curves,...

10.3390/jcm14062024 article EN Journal of Clinical Medicine 2025-03-17

Background: In recent years, reducing adjuvant treatment period from 6 months to 3 in low‐risk stage colon cancer has shown no decline efficiency and fewer adverse effects, particularly neuropathy. Aim: We examined the efficacy side effects of 3‐ 6‐month chemotherapy regimens patients. Methods: Twelve oncology centers retrospectively scanned operated, low‐risk, (T1‐3, N1) Capecitabine oxaliplatin (CAPOX) were given all 3‐month patients, while patients received FOLFOX orCAPOX. Two groups...

10.4103/njcp.njcp_848_23 article EN Nigerian Journal of Clinical Practice 2025-02-01

We aimed to investigate the prognostic value of baseline neutrophil, lymphocyte, and platelet counts along with neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) in local advanced gastric cancer patients.In this retrospective cross-sectional study, a total 103 patients were included. For all, patient characteristics overall survival (OS) times evaluated. Data from complete blood count test including monocyte, white cell (WBC) (Plt) count, hemoglobin level (Hb) recorded, NLR PLR...

10.7314/apjcp.2015.16.14.5933 article EN cc-by Asian Pacific Journal of Cancer Prevention 2015-09-02

The prognosis of breast cancer patients with brain metastasis is poor. It was aimed to define the clinicopathological features metastases and determine risk factors survival outcomes associated metastasis. This a single-center, retrospective, cross-sectional study. A total number 127 diagnosed who developed between January 2011 March 2021 were retrospectively analyzed. data these according 4 biological subtypes evaluated (luminal A, luminal B, HER-2 overexpressing, triple-negative). median...

10.1155/2022/5763810 article EN cc-by The Breast Journal 2022-08-19

We aimed to identify a rapid, accurate, and accessible biomarker in the early stages of COVID-19 that can determine prognosis disease cancer patients.A total number 241 patients with solid cancers who had diagnosis between March 2020 February 2022 were included study. Factors ten different markers inflammation analyzed by year grouped severity infection.Hospitalization, referral intensive care unit (ICU), mechanical ventilation, death more frequent than 2021 (mortality rates, respectively,...

10.1080/03007995.2023.2223917 article EN Current Medical Research and Opinion 2023-06-10

Aim: To show the prognostic significance of glucose-to-lymphocyte ratio (GLR) in hepatocellular carcinoma (HCC). Patients & methods: A total 150 patients with advanced HCC who were treated sorafenib our center between January 2011 and December 2019 included study retrospectively. Neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte platelet-to-lymphocyte nutritional index GLR analyzed to assess their value using Kaplan-Meier Cox regression analysis...

10.2217/fon-2021-0457 article EN Future Oncology 2021-08-25

In this study, we aimed to show the effect of adenosine 5′-triphosphate (ATP) on sunitinib-induced cardiac injury in rats. The rats ( n = 30) were divided equally into three groups as sunitinib group (SG), plus ATP (SAG), and healthy (HG); 2 mg/kg was injected intraperitoneally (ip) SAG group. Same volume normal saline solvent administered ip other two groups. After 1 h, 25 applied orally via catheter stomach SG This procedure repeated once daily for 5 weeks. At end period, all animals...

10.1177/0960327120909874 article EN Human & Experimental Toxicology 2020-03-05

Abstract Objective We aimed to evaluate cardiac safety profile of ribociclib with 24-h rhythm Holter ECG. Material and method Forty-two female metastatic breast cancer patients were included in the study. Rhythm ECG was performed before starting treatment after 3 months initiation. Results The mean age 56.36 ± 12.73. 52.4% ( n = 22) using combination fulvestrant 47.6% 20) aromatase inhibitors. None developed cardiotoxicity. When results third month compared, there no statistically...

10.1007/s00520-024-08702-0 article EN cc-by Supportive Care in Cancer 2024-07-08

The aim of this study is to evaluate the efficacy and toxicity trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) different lines treatment.Retrospective analysis T-DM1 results human epidermal growth factor receptor 2 (Her2) positive 414 mBC from 31 centers Turkey.Except 2, all were female a median age 47. had been used as second-line therapy 37.7% number cycles was 9. Progression-free survival (PFS) overall (OS) times according line treatment. OS found 43, 41, 46, 23...

10.1080/07357907.2021.1933011 article EN Cancer Investigation 2021-05-20

Data on the factors that contribute to antibody response hepatitis B virus vaccination in peritoneal dialysis patients are scarce. The current study was conducted a group of learn how varies according patient's clearance urea normalized total body water (Kt/V).A convenience sample 33 (13 women and 20 men, with mean age 49 ± 12 years) administered double doses (20 μg IM each deltoid muscle) recombinant vaccine at 0, 1, 2, 6 months. Response immunization measured one three months after final...

10.1590/s1807-59322011000900009 article EN cc-by-nc Clinics 2011-09-01

Breast cancer is the most frequently diagnosed in women worldwide. Ribociclib now used treatment of metastatic hormone-positive and human epidermal growth factor receptor 2 (HER 2)-negative breast cancer.A 54-year-old woman with presented at a clinic November 2017 multiple lung bone metastases. After receiving lines due to disease progression, ribociclib fulvestrant were initiated. Grade 4 toxicity was observed during follow-up, discontinued permanently.Management & Outcome: Given that liver...

10.1177/10781552211027931 article EN Journal of Oncology Pharmacy Practice 2021-06-24

Although vaccination is efficacious and prevents infection in the general population, there limited data about Coronavirus disease-19 (Covid-19) occurrence after cancer patients. It was aimed to evaluate efficacy of BNT162b2 (Pfizer-BioNTech) CoronaVac vaccines against Covid-19 patients with cancer. In this single-center, retrospective, cross-sectional, descriptive study, referred medical oncology clinic a university hospital were analyzed. The sample study consisted who had or vaccinated...

10.1002/jmv.27835 article EN Journal of Medical Virology 2022-05-06

We investigated the relationship between maximum standardized uptake value (SUVmax) of whole-body positron emission tomography/computed tomography (PET/CT) performed before treatment and demographical histopathological features in locally advanced breast cancer (LABC), as well role PET/CT evaluation pathological complete response (pCR) after neoadjuvant chemotherapy (NAC).Fifty-one LABC patients who received NAC our center 2011 2015 were retrospectively analyzed. Basal was all NAC. The...

10.5152/eurasianjmed.2018.18036 article EN cc-by Eurasian Journal of Medicine 2018-11-27

Two-thirds of newly diagnosed patients with multiple myeloma (MM) are over 65 yr and/or physically unfit. Such not eligible for high-dose chemotherapy or stem cell transplantation. The treatment aims in these should be to prolong survival by obtaining the best possible response, while maintaining good tolerability. aim our study was evaluate response and treatment-related toxicities treated conventional novel protocols.The records 138 elderly (≥65 yr) MM were retrospectively evaluated.The...

10.1111/ejh.12448 article EN European Journal Of Haematology 2014-09-12

Primary gastrointestinal non-hodgkin lymphomas (PGI-NHL) are uncommon diseases with treatment modalities including chemotherapy, surgery, and radiotherapy. Our aim is to analyze the demographic clinical features results of PGI-NHL.286 patients diagnosed lymphoma who referred Ataturk University Medical Faculty Hospital between July 2001 April 2014 were surveyed retrospectively 22 (7.6%) PGI-NHL cases whose primary lesions in system included.Mean age was 47 (min.25-max.77) 14 (63.6%) them men....

10.5152/eurasianjmed.2019.16071 article EN cc-by Eurasian Journal of Medicine 2019-03-12

Objective The functions of E-selectin, interleukin (IL)-23, and soluble intercellular adhesion molecule (sICAM) in patients with non-small cell lung cancer (NSCLC) before after radiotherapy (RT) are poorly understood. purpose our study was to investigate serum IL-23, E-selectin sICAM levels NSCLC RT. Methods Forty-four pathologically confirmed 30 healthy individuals were included the study. All received 66.6 Gy concurrent Results Significant differences observed between controls both...

10.1177/0300060520923493 article EN cc-by-nc Journal of International Medical Research 2020-05-01
Coming Soon ...