A5031078926- Multiple Myeloma Research and Treatments
- Blood groups and transfusion
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Turkish Literature and Culture
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Cultural and Sociopolitical Studies
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Advanced Glycation End Products research
- Cancer Treatment and Pharmacology
- Blood Coagulation and Thrombosis Mechanisms
- Heat shock proteins research
- Viral-associated cancers and disorders
- Linguistics and Cultural Studies
Kocaeli Üniversitesi
2014-2024
Sağlık Bilimleri Üniversitesi
2020-2021
Bolu Abant İzzet Baysal University
2021
TUBITAK BILGEM
2020
Ankara University
2019
Palmetto Hematology Oncology
2013
Istanbul University
2001
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by dysregulation of T cells. Programmed death (PD) 1 and programmed ligand (PD-L1) are cosignaling molecules, the major role PD-1 pathway inhibition self-reactive cells to protect against diseases. We measured levels serum soluble PD (sPD-1) PD-L1 (sPD-L1) in 67 patients with ITP (24 newly diagnosed [ndITP], 43 chronic [cITP]) 21 healthy controls (HCs). determined decreased sPD-1 both ndITP cITP when compared HC. Moreover,...
Abstract Objectives Hepcidin plays a regulatory role in systemic iron homeostasis. GDF ‐15 has been found to be expressed from matured erythroblasts and very high levels of suppresses hepcidin secretion. In this study, we evaluated polycythemia vera ( PV ) essential thrombocythemia ET ). Methods The study included 29 patients 21 healthy controls. patient group 13 with 16 . Serum were measured at the time diagnosis, before initiation any therapy. Results did not differ significantly chronic...
<b><i>Background/Aims:</i></b> Multiple myeloma (MM) is a hematological cancer associated with increased clonal malignant plasma cells. Growth differentiation factor 15 (GDF 15) protein that highly expressed in the bone marrow mesenchymal stem cells of patients MM. This study investigated whether clinical stage disease, treatment response and survival are affected by pretreatment serum GDF levels. <b><i>Methods:</i></b> Serum levels were...
Background: IL-6, IL1-β, TNF-α and IL-21 have been identified in the growth, progression dissemination of multiple myeloma. To dte, there is no published data about serum levels patients with In present study we investigated circulating cytokines, such as IL-1β, TNF-α, association these disease stage newly diagnosed myeloma patients. Materials Methods: Twenty healthy controls 44 were evaluated. Patients classified according to Durie-Salmon criteria, international staging system (ISS) bone...
Littoral cell angioma (LCA) of the spleen is a relatively recently described rare entity, which associated with haemophagocytosis. In this case report, we will present myelodysplastic syndrome multiple LCA spleen. The patient presented pancytopenia and haemangiomas were observed in during diagnostic abdominal ultrasound. She required transfusion one to two units packed blood every 4-6 weeks she eventually underwent splenectomy order decrease requirement. Although patient's improved after...
Cup-like morphology is defined as cup-like nuclear invagination spanning ≥25% of the diameter in >10% blasts.Studies have shown that FLT3 ITD and normal cytology are strongly associated with acute myeloid leukemia (AML) patients.Herein we describe a patient blasts was diagnosed treated for common lymphoblastic (ALL).In contrast to literature, presented case Philadelphia chromosome positive negative.(
Two-thirds of newly diagnosed patients with multiple myeloma (MM) are over 65 yr and/or physically unfit. Such not eligible for high-dose chemotherapy or stem cell transplantation. The treatment aims in these should be to prolong survival by obtaining the best possible response, while maintaining good tolerability. aim our study was evaluate response and treatment-related toxicities treated conventional novel protocols.The records 138 elderly (≥65 yr) MM were retrospectively evaluated.The...
Background: Tumor lysis syndrome (TLS) is a potentially fatal complication of cancer therapy characterized by severe electrolyte and metabolic abnormalities such as hyperphosphatemia, hyperkalemia, hypocalcaemia. TLS usually occurs in aggressive hematologic malignancies Burkitt lymphoma acute leukemia. has rarely been observed multiple myeloma (MM). Case report: We present 2 patients with relapsed MM who developed after the first cycle carfilzomib treatment. Conclusion: Carfilzomib...
Vascular events are a common complication in patients with polycythemia vera (PV) and essential thrombocythemia (ET). This study aimed to analyze the association between PAI-1 4G/5G ACE I/D gene polymorphisms, leukocytosis thrombosis PV ET.In total, 64 ET were evaluated. Arterial or venous thrombosis, such as cerebral transient ischemic attack, stroke, myocardial infarction, peripheral arterial deep pulmonary embolism, defined vascular event. DNA samples screened for mutations via reverse...
Anticonvulsant hypersensitivity syndrome is a fatal, idiosyncratic drug reaction that caused by aromatic antiepileptic drugs. This cutaneous also called pseudolymphoma because of its clinical and histological similarities with malignant lymphoma. The primary findings are fever, skin rashes, enlarged lymph nodes, single or multiple internal organ involvement hematological abnormalities. Typically, anticonvulsant occurs 1-8 weeks after administration. We herein present the case patient who had...
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by peripheral thrombocyte destruction. In some disorders, heat-shock proteins (HSP) are suggested to be important antigenic factor. this study, we demonstrated the serum free levels of HSP60, HSP70, anti-HSP60, and anti-HSP70 in ITP patients healthy controls. Twenty-eight newly diagnosed patients, 35 chronic phase, 25 controls were enrolled study. Serum determined ELISA method. HSP60 significantly decreased when compared...