A5031738879- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Sepsis Diagnosis and Treatment
- Circular RNAs in diseases
- Advanced biosensing and bioanalysis techniques
- Attention Deficit Hyperactivity Disorder
- Intestinal and Peritoneal Adhesions
- Cardiovascular Function and Risk Factors
- PI3K/AKT/mTOR signaling in cancer
- Functional Brain Connectivity Studies
- Intraperitoneal and Appendiceal Malignancies
- Inflammation biomarkers and pathways
- Clusterin in disease pathology
- Cardiac and Coronary Surgery Techniques
- Cardiac tumors and thrombi
- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Parkinson's Disease Mechanisms and Treatments
- Hydrogen embrittlement and corrosion behaviors in metals
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
Erciyes University
2019-2024
Coronary artery disease is a complex disorder that causes death worldwide. One of the genes involved in developing this may be PTEN.This study aimed to investigate PTEN gene and protein expression tissue blood samples taken from coronary bypass surgery patients.Molecular studies were performed at Erciyes University Genome Stem Cell Center (GENKOK). Right atrial appendage central vein 22 patients before starting ending cardiopulmonary bypass. was determined using quantitative real-time PCR...
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder, with highly variable expression of phenotypes (restricted interest or activity and repetitive behavior in communication social interactions), genes (mutation), markers (alteration transcription) pathways. Loss function the CC2D1A gene appears to primarily affect brain, leading range behavioral problems humans. In our study published 2020; we found that expressions miR-19a-3p, miR-361-5p, miR-150-5p, miR-3613-3p,...
Autism spectrum disorder (ASD) is characterized by impairments in social interaction and the presence of stereotypy restrictive behavior. The clinical heterogeneity ASD makes it difficult to explain mechanisms underlying disease. In recent years, association between autophagy neuropsychiatric diseases has been investigated. this review, we aimed elucidate relationship autism mechanism well-known relevant animal models. Autophagy a cell-protective that allows cell survival low nutrient...
Abstract Background Sepsis is a life‐threatening condition caused by dysregulated host response to infections and leading cause of death in hospitalized patients. The present study aimed elucidate the possible association between sepsis tumor necrosis factor ( TNF ) gene –308G/A (rs1800629) polymorphism, as well endothelial nitric oxide synthase eNOS, NOS3 –786T/C (rs2070744), 4a/4b (27 bp‐VNTR intron 4, rs61722009) 894G/T (Glu298Asp, rs1799983) polymorphisms. Methods In total, 188 septic...
A doença arterial coronariana (DAC) devido à isquemia miocárdica causa perda permanente de tecido cardíaco.Objetivos: Nosso objetivo foi demonstrar o possível dano ao miocárdio em nível molecular através dos mecanismos autofagia e apoptose pacientes submetidos cirurgia revascularização
Introduction: Blood cardioplegia (BC) and Custodiol (CC) have been used for a long time in open heart surgery are highly effective solutions.The most controversial issue among these two is whether there any difference between them regarding myocardial damage after ischemia surgery.In this study, autophagy, apoptosis, hypoxia markers were investigated that way we evaluated the differences BC CC patients.Methods: A total of 30 patients included using different cardioplegic solutions.Three...
Autism spectrum disorder (ASD) is a complex neurodevelopmental with highly variable expression of phenotypes (restricted interest or activity and repetitive behavior in communication social interactions), genes (mutation), markers (alteration transcription) pathways. Loss function the CC2D1A gene appears to primarily affect brain, leading range behavioral problems humans. In our study published 2020, we found that expressions miR-19a-3p, miR-361-5p, miR-150-5p, miR-3613-3p, miR-126-3p...
Neurodevelopmental disorders (NDDs) are the most common psychiatric in childhood, and there many factors their etiology. In recent years, biomarkers have been studied to elucidate etiology of these disorders. this study, it was aimed investigate levels nerve growth factor (NGF) angiotensin converting enzyme 2 (ACE2) attention deficit hyperactivity disorder (ADHD), autism spectrum (ASD), intellectual disability (ID).The study included 74 children with NDDs (the number patients ADHD, ASD ID...
Sepsis is a complex and serious medical condition resulting from the activation of an innate host response to infections. The etiology sepsis can be influenced by genetic susceptibility. purpose present study was investigate possible association Rho-kinase 1 (ROCK1) gene polymorphism with in Turkish population.The group consisted 100 unrelated patients healthy controls. Genomic DNA isolated peripheral leukocytes EDTA-containing blood using QIAamp Blood Mini Kit. ROCK1 rs35996865 rs112130712...
Acute appendicitis represents one of the most common causes acute intra-abdominal emergencies worldwide. In this case-control study, we aimed to investigate associations Rho-kinase gene expression and polymorphisms with in a Turkish population. We also study effects gender on these parameters.A total 93 unrelated patients healthy controls Department Emergency Medicine, Erciyes University, between June 2019 2021 were included study. Genomic DNA was isolated from peripheral leukocytes,...
: Pathways associated with glutamate receptors are known to play a role in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). However, cyclin-dependent kinase 5 (CDK5), microtubule-associated protein-2 (MAP2), guanylate kinase-associated protein (GKAP), and postsynaptic density 95 (PSD95), all which biomarkers involved neurodevelopmental processes closely related glutamatergic pathways, have not previously been studied patients ADHD. The main purpose this study was...