A5034065702- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Pituitary Gland Disorders and Treatments
- Cardiac Ischemia and Reperfusion
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Autophagy in Disease and Therapy
- Telomeres, Telomerase, and Senescence
- Genetic and Kidney Cyst Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Birth, Development, and Health
- Acute Myeloid Leukemia Research
- Neurogenesis and neuroplasticity mechanisms
- RNA Research and Splicing
- Biomedical Research and Pathophysiology
- Congenital heart defects research
- CRISPR and Genetic Engineering
- Traumatic Brain Injury Research
- Neonatal Respiratory Health Research
- RNA Interference and Gene Delivery
- Hydrogen embrittlement and corrosion behaviors in metals
- Cardiovascular Function and Risk Factors
- NF-κB Signaling Pathways
Erciyes University
2018-2025
Cardiff University
2021-2024
Cancer Genetics (United States)
2024
Autism spectrum disorder (ASD) is a group of developmental pathologies that impair social communication and cause repetitive behaviors. The suggested roles noncoding RNAs in pathology led us to perform comparative analysis the microRNAs expressed serum human ASD patients. cohort 45 children with revealed six (miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p, miR-499a-5p) were at low very levels compared those healthy controls. A similar but less pronounced decrease was registered...
Abstract Purpose Traumatic Brain Injury (TBI) poses a significant global health burden, with Mild TBI (mTBI) being the most prevalent form. triggers activation of hypothalamic–pituitary–adrenal (HPA) axis, which in turn affects hypothalamic-pituitary–gonadal (HPG) axis regulating oogenesis and spermatogenesis. In this study, we investigated impact mTBI on sperm genome integrity using repetitive (r-mTBI) mouse model. Methods We assessed telomere length (TL), free TERRA (fTERRA), DNA/RNA...
Functional long non-coding RNAs (lncRNAs) have been in the limelight aging research because short telomeres are associated with higher levels of TERRA (Telomeric Repeat containing RNA). The genomic instability, which leads to telomeres, is a mechanism observed cell and class cancer cells. Psoriasis, skin disease, disorder epidermal keratinocytes, altered telomerase activity. Research on fraction nascent hybrid DNA offers avenues for new strategies. Skin blood samples from patients were...
Recently, we described the alteration of six miRNAs in serum autistic children, their fathers, mothers, siblings, and sperm mouse models. Studies model organisms suggest that noncoding RNAs participate transcriptional modulation pathways. Using mice, approaches to alter amount RNA fertilized eggs enable vivo intervention at an early stage development. Noncoding are very numerous spermatozoa. Our study addresses a fundamental question: can transfer content from result changes phenotypic...
Traumatic brain injury (TBI) is a major health problem affecting millions of people worldwide and leading to death or permanent damage. TBI affects the hypothalamic-pituitary-adrenal (HPA) axis either by primary hypothalamic-hypophyseal region secondary vascular damage, brain, and/or pituitary edema, vasospasm, inflammation. Neuroendocrine dysfunctions after have been clinically described in all hypothalamic-pituitary axes. We established mild (mTBI) rats using controlled cortical impact...
<b><i>Introduction:</i></b> Traumatic brain injuries (TBIs) pose a high risk of pituitary insufficiency development in patients. We have previously reported alterations miR-126-3p levels sera from patients with TBI-induced deficiency. <b><i>Methods:</i></b> To investigate why deficiency develops only some and to reveal the relationship between hormone axes, we used mice that were epigenetically modified at embryonic stage. These subjected mild...
Abstract Quinoa ( Chenopodium quinoa Willd.) is a pseudocereal with rich nutritional composition, gluten free, and organoleptic. The primary aim of this study was to elucidate the possible protective roles in glucose homeostasis model cafeteria diet‐induced obesity. Male Wistar rats (3 weeks age) were randomly allocated be fed by; control chow (CON; n = 6), (QUI; (CAF; or (CAFQ; 6) for 15 weeks. CAFQ resulted decreased saturated fat, sugar, sodium intake comparison CAF. Compared CON, CAF...
Autism Spectrum Disorder (ASD) poses significant challenges to society and science due its impact on communication, social interaction, repetitive behavior patterns in affected children. The Developmental Disabilities Monitoring (ADDM) Network continuously monitors ASD prevalence characteristics. In 2020, was estimated at 1 36 children, with higher rates than previous estimates. This study focuses ongoing research conducted by Erciyes University. Serum samples from 45 patients 21 unrelated...
ABSTRACT Traumatic brain injury (TBI) causes inflammation, one of the main cellular aging. Telomere repeat-containing RNA (TERRA) hybridizes to telomere regions, forming R-loop structures and ensuring genome stabilization. Deregulation homeostasis leads genomic instability linked neurodegenerative diseases cancer. The hypothalamus-pituitary-adrenal (HPA) axis response is critical maintaining after TBI. We showed that local increase in transcription levels Crh Pomc genes, particular, suggests...
Coronary artery disease is a complex disorder that causes death worldwide. One of the genes involved in developing this may be PTEN.This study aimed to investigate PTEN gene and protein expression tissue blood samples taken from coronary bypass surgery patients.Molecular studies were performed at Erciyes University Genome Stem Cell Center (GENKOK). Right atrial appendage central vein 22 patients before starting ending cardiopulmonary bypass. was determined using quantitative real-time PCR...
<b><i>Background and Objectives:</i></b> Cyst pressure induces renin-angiotensin-aldosterone system activation kidney hypoxia in autosomal dominant polycystic disease (ADPKD). Lipopolysaccharide-induced Toll-like receptor causes metabolic disturbances that are triggered by increased succinate levels inducible factors, which results inflammation via <i>IL-1β</i> activation. Since we aimed to investigate the role of both clinical course ADPKD, from sera...
The WHO classifies t(6;9)-positive acute myeloid leukemia (AML) as a subgroup of high-risk AML because its clinical and biological peculiarities, such young age therapy resistance. t(6;9) encodes the DEK/NUP214 fusion oncoprotein that targets only small subpopulation bone marrow progenitors for leukemic transformation. This distinguishes from other oncoproteins, PML/RARα, RUNX1/ETO, or MLL/AF9, which have broad target population they block differentiation increase stem cell capacity. A...
A wide range of diseases result from environmental effects, and the levels many native transcripts are altered. The alteration non-coding RNAs (ncRNAs) transmission variation to next generation is increasingly recognized as a marker disease. However, determining signals mechanisms RNA-induced heritability remain unclear. We performed functional tests with four different genotypes mice maintained on high-fat diet trace transfer obesity/diabetes phenotype in order detect common signals. Two...
Introduction: Blood cardioplegia (BC) and Custodiol (CC) have been used for a long time in open heart surgery are highly effective solutions.The most controversial issue among these two is whether there any difference between them regarding myocardial damage after ischemia surgery.In this study, autophagy, apoptosis, hypoxia markers were investigated that way we evaluated the differences BC CC patients.Methods: A total of 30 patients included using different cardioplegic solutions.Three...
Traumatic brain injury (TBI) is one of the major causes death and disability worldwide, brings a huge burden on quality life patients with TBI country's healthcare system. Peripheral organs, especially kidney, liver, may be affected by onset molecular responses following tissue damage. While secondary post has been well studied in brain, effect/consequences these peripheral organs have not yet fully elucidated. Thus, our study aimed to investigate immunoreactivity responses, particularly via...
Background: N-heptyl-D-galactonamide (GalC7) is a small synthetic carbohydrate derivative that forms biocompatible supramolecular hydrogel. In this study, the objective was to analyze more in-depth how neural cells differentiate in contact with GalC7. Method: Direct (ex vivo) of fresh hippocampus and culture (In vitro) primary were investigated. vitro, investigation performed under three conditions: on neurospheres for 19 days, GalC7 gel 7 both gel. Total RNA isolated TRIzol from each group,...
<title>Abstract</title> Epigenetic mechanisms and RNA signalling profoundly impact body growth during the early stages of embryonic development. modifications' critical role in determining which genes are activated or suppressed, thereby influencing molecules, like microRNAs, regulate gene expression, control cell fate, coordinate cellular processes crucial for proper These complex molecular work harmoniously to create intricate symphony development, lays foundation organism's future...
Abstract Autosomal‐dominant polycystic kidney disease (ADPKD) is associated with oxidative stress and hypertension development before renal function decline cardiovascular development. Oxidative stress‐responsive kinase‐1 (OSR‐1) participates in the signaling regulating Na + transport during also plays a role regulation of cell volume blood pressure. Therefore, we aimed to investigate potential OSR‐1 ADPKD patients. Eighty patients, 80 healthy controls, non‐ADPKD patients were enrolled this...
Abstract Recently, we described the alteration of six miRNAs in serum autistic children, their fathers, mothers, siblings and sperm mouse models. Studies model organisms suggest that noncoding RNAs participate transcriptional modulation pathways. Using mice, approaches to alter amount RNA fertilized eggs enable invivo intervention at an early stage development. Noncoding are very numerous spermatozoa. Our study aims address a fundamental question: Can transfer content from result changes...