The present study was designed to investigate the relationship between serum levels of oxidant-antioxidant system (malondialdehyde (MDA) level, Paraoxonase (PON1) activity, nitric oxide (NO) level and superoxide dismutase (SOD) activity) thyroid hormone status in hypothyroidism pre posttreatment. group comprised 33 patients with primary hypothyoidism. 18 these were reevaluated after euthyroid state i.e. at least 6 months thyroxine replacement. compared 26 normal healthy controls. Serum MDA...

This report describes a rare case of ruptured splenic artery aneurysm presenting with symptoms indistinguishable from renal colic. A 43-year-old male patient presented acute left-sided abdominal pain, radiating to the flank, and hematuria, initially suggesting While diagnosis was being evaluated, patient's vital signs rapidly deteriorated, prompting more aggressive diagnostic approach that revealed aneurysm. The successfully treated emergency surgery. emphasizes importance considering...

Amaç: Bu çalışmada, acil servise başvuran febril nötropeni hastalarında tiyol / disülfid homeostaz parametreleri ile prokalsitonin (PCT), C-reaktif protein (CRP) ve Kanserde Destekleyici Bakım için Çok Uluslu Derneği (MASCC) risk skorlama sisteminin birlikte prognoz mortalitenin öngörülmesi kullanımını belirlemeyi amaçlanmaktadır. Gereç Yöntem: Çalışma prospektif olarak tanısı alan 53 hasta 51 sağlıklı bireyüzerinde gerçekleştirildi. Oksidatif stres markerleri olan tiyol/ Erel Neşelioğlu...

Carbon monoxide poisoning (COP) is one of the important causes morbidity and mortality in toxicological cases. In this study, we aimed to find out more about pathophysiology COP by investigating effects on oxidative stress parameters such as total oxidant status (TOS) antioxidant (TAS).Eighty-eight patients admitted emergency department our hospital with acute 35 healthy adults control group were included study. Blood samples collected from all at time initial evaluation determine...

There are only limited data regarding pituitary functions in the acute phase of traumatic brain injury (TBI) and previous studies have been conducted small cohorts subjects. Therefore we investigated early phase, within 24 hours trauma, 104 patients with TBI. Additionally, relationships between basal hormones, severity trauma mortality due to were also investigated.One hundred four TBI included study consecutively. All underwent hormonal evaluation first admission. Twenty died during...

Traumatic brain injury (TBI) is a major health problem affecting millions of people worldwide and leading to death or permanent damage. TBI affects the hypothalamic-pituitary-adrenal (HPA) axis either by primary hypothalamic-hypophyseal region secondary vascular damage, brain, and/or pituitary edema, vasospasm, inflammation. Neuroendocrine dysfunctions after have been clinically described in all hypothalamic-pituitary axes. We established mild (mTBI) rats using controlled cortical impact...

<b><i>Introduction:</i></b> Traumatic brain injuries (TBIs) pose a high risk of pituitary insufficiency development in patients. We have previously reported alterations miR-126-3p levels sera from patients with TBI-induced deficiency. <b><i>Methods:</i></b> To investigate why deficiency develops only some and to reveal the relationship between hormone axes, we used mice that were epigenetically modified at embryonic stage. These subjected mild...

Subjects and methods: This study was carried out on 13 female patients with PMR who were diagnosed according to the criteria of Chuang et al (Ann Intern Med 1982;97:672–80) 10 healthy subjects in Department Physical Medicine Rehabilitation, Erciyes University Medical School. In patient control groups, basal cortisol, adrenocorticotrophic hormone (ACTH), 17α‐hydroxyprogesterone (17‐OHP), 11‐deoxycortisol (11‐S), dehydroepiandrosterone sulfate (DHEAS), androstenedione (A), prolactin (PRL),...

Aims: Investigating the thiol-disulphide balance in patients with acute renal failure and evaluating potential of using tGFR (thiol based GFR) index as a new parameter, alternative to parameter called estimated Glomerular Filtration Rate (eGFR).Study design: The serum levels predialysis postdialysis blood samples 42 diagnosed emergency department hemodialyzed right after were measured through novel method. Methods: was detected clinical laboratory findings, hemodialysis procedure performed....

ABSTRACT Traumatic brain injury (TBI) causes inflammation, one of the main cellular aging. Telomere repeat-containing RNA (TERRA) hybridizes to telomere regions, forming R-loop structures and ensuring genome stabilization. Deregulation homeostasis leads genomic instability linked neurodegenerative diseases cancer. The hypothalamus-pituitary-adrenal (HPA) axis response is critical maintaining after TBI. We showed that local increase in transcription levels Crh Pomc genes, particular, suggests...

Objective: The congenital adrenal hyperplasias (CAH) are a group of autosomal recessive disorders due to decreased activity the enzymes responsible for cortisol biosynthesis. Since CYP21 gene mutations in non-classical CAH (NC-CAH) 21-hydroxylase deficiency among Turkish women have not been well characterized, we performed genotype analyses determine frequency specific our population.

Objectives Carbon monoxide (CO) is a potent myocardial toxin. We investigated the association between acute CO intoxication and electrocardiographic QT interval (QTmax/QTmin), corrected (cQTmax/cQTmin), dispersion (QTd) (cQTd), P wave duration (Pmax/Pmin) (Pd), which were known as predictors of ventricular arrhythmias, atrial fibrillation sudden death. Methods Electrocardiography with 12-leads blood gas taken from 65 patients well control similar age gender distribution at admission time to...

Traumatic brain injury is a common cause of death after trauma. The aim this study was to investigate the relationship between oxidative stress parameters and, outcomes and clinical findings in patients with isolated traumatic injuries. Fifty-four who were admitted into emergency department Ankara Ataturk Training Research hospital blunt injuries 33 healthy adults as control group, included study. Serum oxidant status evaluated by measuring Total Oxidant Status (TOS) levels individuals....

Background: Community-acquired pneumonia is an important cause of mortality and morbidity in all age groups. Oxidant antioxidant mechanisms play role the pathogenesis community-acquired pneumonia. Objectives: In this study, thiol/disulfide homeostasis diagnosis prognosis was investigated. Methods: This a prospective, controlled, observational study involving 73 patients 68 healthy volunteers. Results: The native thiol total thiol, which are components, were significantly lower group. It also...

Objective: To evaluate the presence of SARS-CoV-2 virus in cerumen patients with COVID-19. Methods: A prospective study was conducted a tertiary care pandemic hospital. Sixty COVID-19 their external auditory canals were included study. Swabs taken from canal by an experienced otolaryngologist test swab. Sampling done rotating sample swab 360° 10 times each for total 20 times. After collection, swabs placed into 2 mL sterile viral transport medium (various manufacturers), then transported and...

Peripheral venous catheterization is one of the most used medical procedures in hospitals worldwide. Recent researches state that using intravascular devices a risk factor for both local and systemic complications. In this study, we aimed to test addition tissue adhesive insertion site peripheral intravenous catheters (PIVC) emergency department (ED) would reduce device failure rate at 6 h 24 following insertion.We designed single-site, two-arm, randomized, controlled trial. We inserted 115...

acquired diaphragmatic rupture is often associated with trauma, rarely it may be spontaneous (atraumatic). Spontaneous rup- ture one of the rarest thoracoabdominal emergencies, and harder to de- tect in patients without visceral damage. Diagnosis delayed by several months or even years. A sceptical approach, combined thorough physi- cal examination correct interpretation chest X-ray, are very im- portant diagnosis. In this report we present a patient who was admitted emergency department...

Permanent daylight saving time has been implemented in Turkey since 2016. The present study determines the characteristics of road traffic collisions short-term, trauma severity, and whether permanent an impact on these parameters.Drivers admitted because to a tertiary care university hospital emergency service two weeks before after transition wintertime 2014 2015 summertime 2016 as well those same period with 2017 2018 were included study. Trauma severity was measured using Injury Severity...