A5081039179- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Corneal surgery and disorders
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Treatments and Studies
- Traumatic Ocular and Foreign Body Injuries
- Radiomics and Machine Learning in Medical Imaging
- Vascular Malformations Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Melanoma and MAPK Pathways
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
Ondokuz Mayıs University
2023-2024
Hamad Medical Corporation
2023-2024
Weill Cornell Medical College in Qatar
2024
Istanbul Eye Hospital
2016-2023
University of Khartoum
2023
Hamad General Hospital
2023
Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi
2020-2023
Acıbadem University
2015-2022
Sağlık Bilimleri Üniversitesi
2017-2021
Beyoglu Goz Egitim ve Arastirma Hastanesi
2018-2021
Stromal-derived factor (SDF)-1 and its G protein–coupled receptor, CXCR4, regulate stem/progenitor cell migration retention in the marrow are required for hematopoiesis. We show here an interaction between CXCR4 Src-related kinase, Lyn, normal progenitors. demonstrate that CXCR4-dependent stimulation of Lyn is associated with activation phosphatidylinositol 3-kinase (PI3-kinase). This chemokine signaling, which involves a kinase PI3-kinase, appears to be target BCR/ABL, fusion oncoprotein...
Soft soils require particular consideration when designing civil engineering structures due to their high compressibility, low shear strength, and permeability. Using chemical additives geopolymers stabilize soft is a practical approach improve properties. The objective of the study was explore use conventional stabilizers alongside metakaolin-based geopolymers. This also aimed investigate compaction characteristics, mechanical behavior, microstructure stabilized soil. test carried out using...
This study aimed to determine the epidemiological characteristics of colorectal cancer in Turkey.In this multicenter, prospective, and cross-sectional registry study, data for 968 patients with from 21 centers 7 geographic regions were analyzed.Diagnosis was colon 662 (68.4%) rectum 306 (31.6%) patients. In total, 60.9% male; mean age 58.9±12.6 years. Among patients, 15.0% drinking alcohol, 17.5% smoking, 1.5% had familial history polyposis, diabetes mellitus, 1.0% inflammatory bowel...
The prognostic value of the ocular trauma score (OTS) in patients who underwent 23-gauge pars plana vitrectomy (23-G PPV) for surgical removal posterior segment metallic intaocular foreign bodies (IOFB) was evaluated.Patients 23-G PPV retained IOFBs were retrospectively analyzed. OTS each patient calculated and raw scores converted to their corresponding categories. final VAs study compared with respective categories.Twenty-five eyes from 25 examined. Twenty-four (96%) male, mean age 34 ± 12...
Brucellosis (undulant fever) is a zoonotic infection caused by Brucella species. It typically presents with fever, malaise, night sweats, and arthralgia. One of its rare complications infective endocarditis, which occurs in approximately 1.3% patients can be further complicated embolic stroke. This report describes occurrence endocarditis presenting as an A 34-year-old male presented sudden left-sided weakness fever. He reported headaches, generalized the preceding week. The patient worked...
Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer (BC) prevention. It also related to prognosis after diagnosis and treatment. The aim of our study was determine the prevalence vitamin as measured by serum 25-hydroxy (25-OHD) levels in patients with BC evaluate its correlations life-style treatments.This included 186 stage 0-III treated center between 2010-2013. correlation baseline 25-OHD supplement usage, age, menopausal status, diabetes...
To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), to compare results those obtained healthy controls.FAZ parameters, flow area choriocapillaris, vessel density values both superficial (SCP) deep capillary plexuses (DCP) were measured using OCTA.The FAZ SCP, full retinal vasculature, perimeter significantly higher density-300 was...
One of the most important adverse effects zoledronic acid (ZA) is osteonecrosis jaw (ONJ). In previous literature, several risk factors have been identified in development ONJ. this study, we aimed to determine role trastuzumab, an antiangiogenic agent, as independent factor for serious side effect. Our study included 97 patients (mean age: 54 ± 10 years) with breast cancer, recorded archives Istanbul Florence Nightingale Breast Study Group, who received ZA therapy due bone metastases...
To investigate choroidal vascular index (CVI) in eyes with nanophthalmos (NO) the use of optical coherence tomography (OCT).Macular enhanced depth imaging OCT scans 25 patients NO and age-gender-matched control subjects were analysed. Images binarized using ImageJ software, total choroid area (TCA), luminal (LA) stromal (SA) acquired. The main outcome measure was CVI, defined as ratio LA to TCA.Twenty-five enrolled. mean TCA, SA found be significantly higher (2.51 ± 0.44 vs. 1.91 0.35 mm2, P...
The neonatal immune system is immature and may be affected by Bacillus Calmette-Guèrin (BCG) vaccine. We investigated the influence of BCG given at two different ages on peripheral blood (PB) T-cell subpopulations. Forty full term healthy newborns were randomly chosen. Twenty them vaccinated with birth (group I) remaining age 2 months II). cell analysis carried out before (pre-BCGI pre-BCGII), after (post-BCGI post-BCGII) vaccination. gamma/delta alpha/beta receptor (TCR) antigens was done...
Purpose . To compare the visual and anatomic outcomes in patients with persistent diabetic macular edema (DME) who switched from ranibizumab to aflibercept those continued previous therapy. Methods In this retrospective comparative study, medical records of consecutive center-involved DME ≥ 350 μ m had at least three recent monthly injections followed by as-needed therapy either or were reviewed. Data collected presentation (preinjection), intermediary visit, last visit (at end follow-up...
Hepatocellular carcinoma (HCC) is the fifth most common male-predominant type of cancer worldwide. There no effective treatment regimen available for advanced‑stage disease and chemotherapy generally ineffective in these patients. The number studies on prevalence K‑Ras mutations HCC patients currently limited. A total 58 from 6 comprehensive centers 4 metropolitan cities Turkey were enrolled this study. Each center committed to enroll approximately 10 random whose formalin‑fixed...
Oxaliplatin is used to treat advanced colorectal cancer. Platinum-containing chemotherapeutic agents are known be ototoxic. However, ototoxicity rare with newer generation platinum-derived agents, such as oxaliplatin. This case report presents a of sudden unilateral sensorineural hearing loss following intravenous (IV) infusion oxaliplatin in 64-year-old woman colon The was severe and did not respond treatment. To the best our knowledge, this fifth reported ototoxicity. Although rare,...
The objective of this study was to determine how long wait in locally advanced rectal tumor (LARC) patients who receive total neoadjuvant therapy (TNT) and achieve a clinical complete response (cCR), identify the parameters that affect waiting period for watch-and-wait strategy (W &W).The data achieved cCR between February 2015 June 2020 were examined retrospectively. week which with at end TNT clearance determined by reanalyzing recorded endoscopy video images. In assessment time initial...
Purpose: To compare the efficacy of ranibizumab and aflibercept in treatment diabetic macular edema associated with subfoveal retinal detachment. Methods: This is a retrospective, comparative study. The treatment-naïve patients who had detachment underwent intravitreal or were included. treated on pro re nata regimen after loading dose 3-monthly injections follow-up time was 12 months. primary outcome measure this study presence at different points. secondary measures change best corrected...
We report a case of metastatic malignant melanoma that presented with macroscopic hematuria and lower urinary tract symptoms. Effective palliation symptoms was achieved transurethral resection lesions in the bladder. However, patient lost due to widespread disease despite systemic therapy. Solitary or multiple dark blue-black nodular vegetating encountered during cystoscopy should raise suspicion metastasis be investigated accordingly.
Gastrointestinal stromal tumors (GIST) are rare of the gastrointestinal system. The most common primary site GIST is stomach. treatment primarily surgery, and standard medical therapy imatinib. Long-term survival can be obtained with good follow-up treatment.In this study, data entry was performed using a web-based patient registry system for patients who were referred to 3 centers retrospectively diagnosed GIST.The study cohort consisted 249 patients, including 160 men (64.3%) 89 women...
The KRAS pathway and studies evaluating as a prognostic marker in colorectal cancer are discussed along with advances gene mutation testing. Highly sensitive real-time polymerase chain reaction (PCR) methods were developed for this purpose. We examined the applicability of direct sequencing two PCR diagnosis mutations. used sequencing-based to determine these tests 64 cancers. DNA samples found be positive by analyzed again after diluting 100-fold. results same. When we applied same strategy...