A5020762087- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Immune cells in cancer
- Cancer and Skin Lesions
- Cancer, Stress, Anesthesia, and Immune Response
- Immune Cell Function and Interaction
- Pelvic and Acetabular Injuries
- Male Breast Health Studies
- Hip and Femur Fractures
- Autopsy Techniques and Outcomes
- HER2/EGFR in Cancer Research
- Medical Imaging and Pathology Studies
- Trauma and Emergency Care Studies
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Foreign Body Medical Cases
- Cancer Treatment and Pharmacology
- Esophageal and GI Pathology
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Spinal Fractures and Fixation Techniques
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
Istanbul University
2020-2024
Npistanbul Brain Hospital
2020
High expression of immune checkpoint receptors (ICRs) in the tumor microenvironment regulates anti-tumor response. In this study, differential expressions ICRs on tumor-infiltrating lymphocytes (TILs) patients with early-stage breast cancer were investigated.The study included 32 who underwent surgery a diagnosis between September 2018 and March 2020. TIL isolation was performed using MACS separation device kit. PD-1, CTLA-4, LAG-3, TIM-3, TIGIT cytotoxic T natural killer (NK) cells TILs...
Background Gynecomastia is a benign condition that develops due to the proliferation of breast tissue in men. Surgical excision most effective treatment method. Minimally invasive techniques can be used avoid visible scarring. We evaluated efficacy and safety air-assisted subcutaneous mastectomy gynecomastia. Patient Methods 10 patients with gynecomastia underwent liposuction through single axillary incision, between June 2022 February 2023. Demographic clinical data patients, duration...
Gynecomastia is a common type of breast tissue hypertrophy in men. Surgical excision the most effective treatment for this condition. Minimally invasive surgical techniques can be used to avoid visible chest scarring. In study, we evaluated efficacy and safety single-axillary-incision endoscopic mastectomy liposuction gynecomastia. Nipple-sparing via single-port axillary incision was successfully performed all patients. Twenty-four bilateral procedures were total. Twenty patients underwent...
Abstract Background The omission of axillary lymph node dissection (ALND) remains controversial for patients with residual disease after neoadjuvant chemotherapy (NAC), regardless the burden. This study evaluated oncologic safety and factors associated outcomes in disease. These were treated solely sentinel biopsy (SLNB) or targeted (TAD), without ALND, NAC. Methods A joint analysis two different multicenter cohorts—the retrospective cohort registry MF18‐02 prospective observational MF18‐03...
Optimal and tailored surgical treatment of phyllodes tumour(PT) the breast is controversial. This study aims to determine appropriate margin in PT.The data 132 patients who underwent surgery with diagnosis PT at Breast Unit Istanbul Faculty Medicine from 2000 2022 were retrospectively reviewed.Median age was 38 benign younger than others(median 34, 44, 43 for benign, borderline, malignant, respectively) (P = 0.001). Local recurrence observed 7 (5.3%) patients, systemic 3 (2.3%)...
Immune checkpoint receptors (ICRs) were recently found to modulate the anti-tumoral immune response.This study aimed determine clinical and pathological associations of ICRs expression on tumor-infiltrating lymphocytes (TILs) in patients with locally advanced breast cancer (LABC) treated neoadjuvant chemotherapy (NAC).Expressions including PD-1, LAG-3, TIM-3, TIGIT, CTLA-4 CD8 + T Natural Killer (NK) cells TILs analyzed by flow cytometry.Patients <50 years more likely express compared those...
Abstract ABSTRACT Background Individualized treatment strategies are highlighted for breast cancer patients in the last decades. Therefore aggressive surgical approaches have begun to evolve towards minimally invasive tailored interventions. SLNB is widely used who received neoadjuvant (NAC) and axillary lymph node dissection (ALND) recommended with residual disease after NAC. In our study, we investigated regional recurrence rates limited NAC underwent imaging-guided (MR+USG) surgery plus...
<title>Abstract</title> Background Sentinel lymph node biopsy(SLNB) is widely used in patients who receive neoadjuvant chemotherapy(NAC). Still, axillary dissection(ALND) recommended for with any residual disease after NAC. The necessity of ALND minimal unclear. We aim to investigate regional recurrence rates limited NAC underwent SLNB + image-tailored surgery and adjuvant radiotherapy (RT). Methods Patients clinical stages were T1-3 N1 at the time diagnosis, clinically good or complete...
Abstract Background: Recent advances in tumor biology and immune system have identified check points modulating the anti-tumoral response. This study aimed to determine point expressions patients with locally advanced breast cancer explore any associations between clinical prognostic factors show effectiveness of targeted therapies for these molecules. Materials Methods: prospective was carried out September 2018 November 2019 Department General Surgery Istanbul University Faculty Medicine...
Abstract High expression of immune checkpoint receptors (ICRs) in the tumor microenvironment regulates anti-tumor response. In this study, differential ICRs on tumor-infiltrating lymphocytes (TILs) patients with early-stage breast cancer were investigated. The study included 32 who underwent surgery a diagnosis between September 2018 and March 2020. TIL isolation was performed using MACS separation device kit. PD-1, CTLA-4, LAG-3, TIM-3, TIGIT cytotoxic T natural killer (NK) cells TILs...
Abstract Introduction: High expression of immune checkpoint receptors in tumor microenvironment reduces antitumor immunity and cause evasion cells. In recent years, immunotherapy trials using PD-1 or PDL-1 inhibitors advanced triple negative (TN) breast cancer evolved very rapidly. The differential novel such as TIM-3, LAG-3 TIGIT addition to PD-1, CTLA-4 on infiltrating lymphocytes (TIL) patients with early was investigated. Material methods: TIL were isolated by a Tumor Dissociation Kit...
Abstract Introduction Morel Lavallée lesion is a hemolymphatic collection in between muscular fascia that can be caused by the separation of soft tissue and degloving fashion. an infrequent but should known for medico-legal reports rare presentation cause life-threatening septic hemorrhagic shock. Case Presentation In this case report we are going present which with shock bleeding mortal. Our patient, fourty seven years old male, arrived at emergency department ambulance 1 hour after...