A5039408266- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Hepatitis B Virus Studies
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Radioactivity and Radon Measurements
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Radiation Dose and Imaging
- Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Oral Health Pathology and Treatment
- Gastrointestinal disorders and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Colorectal and Anal Carcinomas
- Nigella sativa pharmacological applications
- Genital Health and Disease
- Ion channel regulation and function
- Pharmacological Receptor Mechanisms and Effects
- Cancer Risks and Factors
- Advances in Oncology and Radiotherapy
- Ear and Head Tumors
Sivas State Hospital
2021-2025
Sivas Cumhuriyet Üniversitesi
2022-2024
Karadeniz Technical University
2018-2022
Regorafenib is a multikinase inhibitor. It used for metastatic colorectal cancer (mCRC) treatment. has mild effect. outcomes, and side effects may vary across patients. This study was aimed to evaluate the factors that affect regorafenib outcomes in mCRC We conducted single-center retrospective study. Fifty-six patients were included. All had received mCRC. Some clinical pathological of these on overall survival (OS), progression-free (PFS), disease control rates (DCR) analyzed. Concomitant...
Abstract Background In the current study, effect of hormone receptor (HR) status on clinical and survival in early-stage human epidermal growth factor 2 (HER2)-positive breast cancer was investigated. Methods Two hundred ninety-one patients with HER2- positive were examined two categories as HR-positive HR-negative. Results Of these, 197 (68%) 94 (32%) HR-negative a mean follow-up period 68 ± 2.7 months. The groups found to be similar terms age, menopausal status, comorbidity, pathologic...
The prognosis of patients with advanced HCC can vary widely depending on factors such as the stage cancer, patient's overall health, and treatment regimens. This study aimed to investigate survival outcomes associated in hepatocellular carcinoma (HCC). In this retrospective study, data from 23 medical oncology clinics were analyzed. Progression-free (PFS) (OS) values estimated using Kaplan–Meier method. Prognostic which identified univariate analysis subsequently evaluated a multivariate...
To investigate factors that may affect prognosis in gastrointestinal stromal tumors (GISTs).A descriptive study.Karadeniz Technical University Hospital, Trabzon, Turkey from 2000 to 2019.All the patients diagnosed with GIST and followed-up this centre were included. Those who not excluded. The Chi-square test for differences between variables independent groups; Kaplan-Meier method survival rates used.Median tumor size was larger recurrence, compared those without (8cm vs. 5 cm, p <0.001)....
INTRODUCTION: Breast-cancer is a common-cause of death in women.(1)We investigated the effects before/after-NACT on hemoglobin-albumin-lymphocyte-platelet (HALP) scores and changes therein clinical/pathological-responses.MATERIALS AND METHODS: One-hundred-twenty-seven breast-cancer-patients receiving-NACT between December 2009 -January 2019 were retrospectively.RESULTS: The mean -age was 50.3±12.3(min 27 -max 79), 125 patients (98.4 %) women.Fiftyfour (42.5 premenopausal 71 (55.9...
Erlotinib is a tyrosine kinase inhibitor that inhibits epidermal growth factor receptor. It being used for metastatic non-small cell lung cancer patients (NSCLC). Repurposing noncancer drugs treatment current issue and it has many advantages. We planned to reveal the effects of [calcium channel blockers (CCBs) others] on erlotinib. scanned files NSCLC retrospectively who were applied Karadeniz Technical University between January 2013 April 2019 There 63 patients, 9 them taking CCB...
<title>Abstract</title> Purpose Human epidermal growth factor-2 (HER-2) targeted drugs are used in only HER-2 overexpressed cancers. However, a small portion of these cancer types overexpressed. In this study, we aimed to upregulate receptors MCF-7 breast and HT-29 colon cell cultures, which cells not upregulated natural status. Methods We 10-day non-cytotoxic lapatinib dose receptors. levels lines were tested with ELISA immunofluorescence tests before after 10 days administration. After...
Purpose: In this study, we investigated the clinical characteristics and survival outcomes of patients diagnosed with special types breast cancer who presented to our clinic. Material Methods: The demographic, clinicopathological, all rare, histologically subtype applied Cumhuriyet University Oncology Center between 2010 2020 were retrospectively reviewed. Results: records 1198 invasive examined, 104 them (8%) identified as having other histological subtypes. Of these, 19 had apocrine...
Neoadjuvant epirubicin docetaxel in breast cancer'A different yet traditional approach to neoadjuvant treatment of cancer:The combination and
SUMMARY OBJECTIVES: Black cumin is widely used as a spice and traditional treatment. The active ingredient in black seeds thymoquinone. Thymoquinone has shown anticancer effects some cancers. We planned to investigate its effect on pancreatic cancer cell lines. METHODS: chemical component various doses was prepared inoculated culture, healthy mesenchymal stem cells, peripheral blood mononuclear culture. IC50 values were calculated by absorbance data measuring viability...
Background: Reactivation of the hepatitis B virus (HBV) either during or after chemotherapy may cause serious and sometimes fatal hepatitis. All patients undergoing should therefore be screened in terms HBV before chemotherapy. The purpose this research was to identify screening rates with solid cancer parenteral determine outcomes screening. Methods: Data for from January 1, 2012 December 30, 2018 were retrieved our electronic health record patient files retrospective study. Screening...
To investigate the prognostic significant of lymph node ratio and surgical margins in patients with colon cancer undergoing surgery.This observational retrospective study was conducted at Karadeniz Technical University Medical Faculty, between 1 January, 2010 31 November, 2020. A series 137 who had undergone resection carcinoma were included this study. mLNR, defined as number mLNs to examined nodes, calculated colorectal cases metastasis. Patients divided into three groups; LNR1 (< 0.25),...
Amaç: Meme kanseri dünya genelinde kadınlarda en sık görülen kanser türüdür ve tanı anındaki evre prognoz için önem arz etmektedir. Kanser taramalarında artış, beslenme alışkanlığı değişiklikleri, görüntüleme yöntemlerindeki gelişmeler toplumsal farkındalığın artması gibi faktörlerin, zaman içerisinde evreyi etkileyebildiği düşünülmektedir. Bu nedenle araştırmada iki farklı yıl aralığında teşhis edilen meme hastalarında evreler karşılaştırılmıştır. Yöntem: Araştırma Karadeniz Teknik...
Aim: Interleukin 28B (IL28B) gene polymorphism may play a role in hepatitis B virus (HBV) infection prognosis. We investigated the effects of IL28B on viral clearance and load chronic (CHB) patients.Material Methods: included 146 individuals who applied to our center between October 2011 2012. CHB (N=117) control (N=29) groups were compared terms rs12979860, rs12980275 region polymorphisms, expression (mRNA) levels.Results: There was no statistically significant difference rs12979860 rates...
Aim: Repurposing non-cancer drugs may be a new hope for cancer treatment.It has many advantages.Sunitinib is tyrosine kinase inhibitor that inhibits vascular epithelial growth factor receptors.It used metastatic renal cell carcinoma (mRCC) treatment.We planned to investigate the effects of noncancer like calcium channel blockers (CCBs) and others on sunitinib in mRCC patients.Material Methods: We retrospectively scanned files patients applied our center between January 2013 April 2019...
Objective: Repurposing non-cancer drugs for cancer treatment has many advantages. We can access to a new drug easily, quickly and cheaply. In addition, we generally know safety prifile of repurped drugs. There are few studies in the literature investige anticancer effects Calcium channel blockers (CCBs). planned investigate CCBs on colon cell line.
 Material Method: adminestered different doses T-type CCB NNC-55-0396 L-type amlodipine line HT-29. MTT analysis was performed at 48 hours...