A5077442313- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
- Angiogenesis and VEGF in Cancer
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Blood Coagulation and Thrombosis Mechanisms
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Peptidase Inhibition and Analysis
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Research Studies
- Ovarian cancer diagnosis and treatment
- Growth Hormone and Insulin-like Growth Factors
- Inflammatory Biomarkers in Disease Prognosis
- Cellular Mechanics and Interactions
- Toxin Mechanisms and Immunotoxins
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Chemokine receptors and signaling
- Galectins and Cancer Biology
- HER2/EGFR in Cancer Research
- Macrophage Migration Inhibitory Factor
Istanbul University
2012-2021
Purpose: Breast cancer is the most prevalent form of among women worldwide, and a complex disease. The development biomarkers for early diagnosis promising avenue improving treatment breast cancer. Doublecortin-like kinase 1 (DCLK1) member protein superfamily doublecortin family. It has been hypothesised that cells expressing DCLK1 in these tumours exhibit stem cell characteristics, suggesting potential association with tumour initiation mortality. objective this study was to evaluate serum...
Angiogenesis is essential for tumor progression and metastasis; however, the angiogenesis regulators that are biologically relevant melanoma still unknown. In this study, we analyzed circulating serum levels of potent angiogenic factors, including vascular endothelial growth factor (VEGF), angiogenin, transforming factor-beta1 VEGF receptors, VEGFR1 VEGFR2, in human patients. One hundred fourteen patients with histopathologically verified cutaneous at different stages 30 healthy controls...
This study was conducted to determine the value of angiogenic serum factors, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), in patients with small cell lung cancer (SCLC). These factors were measured 34 SCLC on before after chemotherapy comparison 20 healthy controls using ELISA method. Serum levels VEGF IL-8 significantly increased compared (p < 0.001). No statistically significant relationships found between investigated elevated parameters various characteristics...
Tenascin-C (TNC) is an extracellular matrix protein that expressed at low levels in normal adult tissue but highly around many tumors including ovarian tumors. The objective of this study was to determine the clinical significance serum TNC epithelial cancer (EOC) patients. A total 50 patients with a pathologically confirmed diagnosis EOC were included study. Serum determined by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. Age- and sex- matched 28 healthy controls...
The aim of this study is to evaluate the correlation coagulation tests with various clinicopathological variables and tumor markers among colorectal cancer (CRC) patients.Ninety-four CRC patients were included for evaluation factors, assays marker levels.Metastatic disease was related elevated INR (p= 0.03). Stage III had higher D-dimer values compared stage II Correlation indicated a tendency towards levels CEA than median 0.01). High CA 19-9 also associated 0.007). Elderly age, distant...
Activated coagulation and fibrinolytic system in cancer patients is associated with tumor stroma formation metastasis different types. The aim of this study to explore the correlation blood assays for various clinicopathologic factors breast patients. A total 123 female were enrolled into study. All treatment naïve. Pretreatment tests including PT, APTT, PTA, INR, D-dimer, fibrinogen levels, platelet counts evaluated. Median age diagnosis was 51 years old (range 26-82). Twenty-two percent...
Insulin-like growth factor-1 (IGF-1) and its essential binding protein-3 (IGFBP-3) exhibit significant roles in cellular proliferation, differentiation apoptosis numerous malignancies, including lung cancer. The aim of the present study was to determine clinical serum IGF-1 IGFBP-3 levels cancer patients. A total 80 patients with were enrolled study. Serum concentrations determined by ELISA methods. median age 58.5 years old, a range 36-80 years. majority had non-small cell (NSCLC) (85%)...
The characteristic changes in cancer process are assumed to be genetic alterations about the imbalance of cell proliferation and apoptotic death. This study was conducted determine value circulating vascular endothelial growth factor (VEGF) Bcl-2 patients with advanced stage non-small lung (NSCLC). These serum factors were measured 52 NSCLC pathologically verified on before after chemotherapy comparison 16 healthy controls by using ELISA method. Both levels VEGF (p = 0.015) < 0.001)...
Cellular adhesion molecules might be good markers in some types of malignant tumors, useful information diagnosis and prognosis. The objective this study was to evaluate the serum levels epithelial cell molecule (EPCAM) vascular molecule-1 (VCAM-1) ovarian cancer (EOC) patients. Fifty patients were enrolled into study. Serum EPCAM VCAM-1 determined by solid-phase sandwich ELISA method. Age- sex-matched 30 healthy controls included analysis. median age 56.5 years, range 22 83 years. Majority...
Transforming growth factor-beta 1 (TGF-β1) plays an important role in the pathogenesis of multiple malignancies, and its expression also strongly affects outcomes cancer patients. The objective this study was to determine clinical significance serum levels TGF-β1 melanoma A total 60 patients with a pathologically confirmed diagnosis were enrolled into study. Serum concentrations determined by solid-phase sandwich ELISA method. Thirty age- sex-matched healthy controls included analysis....
The transforming growth factor beta 1 (TGFB1) is a regulatory cytokine with both tumor suppressor and tumor-promoting effects in breast cancer (BC) cell lines tissue. Data about level of circulating TGFB1 its prognostic significance BC patients conflicting. objective this study to determine the clinical serum levels patients. We enrolled 96 female histopathologically diagnosed who did not receive chemotherapy (CT) or radiotherapy. Serum were measured by ELISA method compared 30 healthy...
The objective of this study was to investigate the expression macrophage migration inhibitory factor (MIF) in patients with colorectal cancer (GIS) and malignant melanoma (MM). group consists pathologically verified (n = 63) 65) healthy controls 25). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay. values significantly higher than (p < 0.001 for GIS, p 0.032 MM). Diagnostic sensitivity specificity calculated melanoma. results demonstrate that express secrete...