A5025032206- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Diet and metabolism studies
- Congenital Anomalies and Fetal Surgery
- Nutrition and Health in Aging
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Nutritional Studies and Diet
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Parasitic infections in humans and animals
- Multiple and Secondary Primary Cancers
- Colorectal Cancer Screening and Detection
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Inflammatory Bowel Disease
- Phytoestrogen effects and research
- Vascular anomalies and interventions
TÜBİTAK Marmara Research Center
2011-2024
Ankara University
2015-2023
Sağlık Bilimleri Üniversitesi
2021
Scientific and Technological Research Council of Turkey
2011-2019
University Gastroenterology
2019
Gazi University
2010-2014
In a proof‐of‐concept (POC) study, the oral prenylation inhibitor, lonafarnib (LNF), decreased hepatitis D virus (HDV) RNA during 4 weeks of treatment. Here, we explored optimal LNF regimens. Fifteen patients (five groups; 3 per group) completed dosing as follows: (1) 200 mg twice‐daily (BID; 12 weeks); (2) 300 BID (12 (3) 100 thrice‐daily (5 (4) + pegylated interferon alfa (PEG‐IFNα) 180 μg once‐weekly (QW; 8 and (5) ritonavir (RTV) once‐daily (QD; weeks). Tolerability efficacy were...
The relative ranking of cirrhosis-related deaths differs between high-/middle-income countries. Gut microbiome is affected in cirrhosis and related to diet. Our aim was determine the effect differing dietary habits on gut microbiota clinical outcomes. Outpatient compensated/decompensated patients with controls from Turkey United States underwent stool analysis. Patients were followed till 90-day hospitalizations. Shannon diversity multivariable determinants (Cox binary logistic) microbial...
Interferon is the only treatment option in chronic delta hepatitis (CDH). A CDH database (333 patients, 161 with interferon history) was analyzed for effects of duration on virologic response and clinical outcomes. Ninety-nine patients who received at least 6 months were selected. Maintained (MVR) defined as D virus RNA negative 2 years after discontinuation. Cumulative median 24 (range 6–126 months), a courses 1–8). Post-treatment follow-up 55 (24–225 months). Thirty-five achieved MVR....
Proof-of-concept studies demonstrated lonafarnib (LNF), a first-in-class oral prenylation inhibitor, efficacy in patients infected with HDV. The ritonavir for HDV-2 (LOWR-2) study's aim was to identify optimal combination regimens of LNF + (RTV) ± pegylated interferon alpha (PEG-IFNα) and tolerability longer-term dosing. Here we report the safety at end treatment up 24 weeks.
The objective of the present study was to investigate prevalence metabolic-associated fatty liver disease (MAFLD) in patients with dyspepsia.
Abstract Background: In support of Project LUNGMARK, LUNGBANK was established as a pioneering biorepository dedicated to lung cancer. Designed for streamlined biospecimen handling, it employs high-volume technologies secure high-quality samples. Fortified with robust data management, efficiently integrates diverse datasets. This strategic infrastructure positions more than repository; operates sophisticated platform advanced cancer research, amplifying the potential meaningful discoveries....
Dietary changes can modulate gut microbiota and interact with cirrhosis. Our prior study demonstrated that microbial diversity was higher in cirrhotics from Turkish vs the USA, which associated lower risk of 90-day hospitalizations. We aimed to define functional metabolomic increase insight into benefits Mediterranean compared Western diets.
Aim Vitamin B 12 deficiency is frequent in older patients, and the main reason pernicious anemia. However, vitamin can occur patients who do not have atrophic gastritis. The aim of present study was to investigate factors affecting serum levels with non‐atrophic Methods A total 1256 out 1607 aged over 60 years had undergone upper gastrointestinal endoscopy for various reasons, value were diagnosed as having “non‐atrophic gastritis” analyzed by means low levels. Results Non‐atrophic gastritis...
Acute gastrointestinal bleeding is a potentially life-threatening condition that requires rapid assessment and dynamic management. Several scoring systems are used to predict mortality rebleeding in such cases. The aim of the present study was compare three for predicting short-term mortality, rebleeding, duration hospitalization need blood transfusion elderly patients with upper bleeding.The included 335 bleeding. Pre- post-endoscopic Rockall, Glasgow-Blatchford AIMS65 scores were...
Background Finite treatment of hepatitis B e antigen (HBeAg)-negative chronic (CHB) with nucleoside/nucleotide analogues (NAs) is important in resource-limited countries. Outcome discontinuation patients on long-term lamivudine (LVD) was assessed a single centre observational pilot study the current study. Methods Non-cirrhotic LVD for at least 5 years undetectable HBV DNA two consecutive assessments were offered to stop treatment. Biochemical, serological and virological measures determined...
Type-2 diabetes (T2D) is the most common type of chronic disease in adults and accounts for around 90% all cases diabetes. Therefore, developing dietary supplements from natural sources, such as teas, great interest. Seven diet groups together with a parallel control group were used three periods 16 weeks total [stabilization period (W-2-W0), model (W0-W8), treatment (W8-W14)]. The primary aim this study was to investigate vivo antidiabetic activities green black tea polysaccharides (GTPS...
Background/Aims: Hydatid disease remains an important global socioeconomic health problem, particularly in the endemic areas.Although half of patients show no symptoms, hydatid cysts should be treated because their fatal complications.The aim this study is to present long-term results percutaneous treatment using Örmeci technique.Materials and Methods: Forty-nine with 54 cystic lesions were diagnosed disease.Twenty-seven located spleen punctured a 22-gauge Chiba needle through parenchyma...
Celiac disease is an autoimmune enteropathy with variable clinical symptoms. Elderly patients can have different manifestations from those of young patients. The aims the present study were to investigate whether any differences or similarities exist between older and celiac a special emphasis on concurrent diseases.Celiac stratified as younger These two groups then compared by means symptoms, laboratory parameters diseases. Factors associated presence identified univariate multivariate...
Percutaneous endoscopic gastrostomy is a method of providing enteral feeding to patients who cannot take adequate oral nutrition. The aims this study were determine the performance malnutrition and mortality scoring systems for predicting short long-term in elderly had undergone procedure due non-malignant conditions.
Both hepatitis C virus infection (HCV) and chronic kidney disease (CKD) have been comorbid illnesses with increasing morbidity mortality. The present study was conducted to real-life experiences about treatment of HCV CKD a fixed-dose combination paritaprevir 150 mg/day, ritonavir 100 mg/day as booster, ombitasvir 25 dasabuvir 250 mg twice/day, the PROD regimen.This multicenter, retrospective cohort study. Seventy-five patients both were treated PROD-based regimen or without ribavirin....
Chromogranin A is an important tool in the diagnosis of neuroendocrine tumors. Autoimmune gastritis autoimmune disorder marked by hypergastrinemia, which stimulates enterochromaffin-like cell proliferation. also elevated patients with a different level increase each patient. The goal this study to explore constituents that influence serum chromogranin levels patients.One hundred and eighty-eight 20 type I gastric carcinoid tumors were analyzed retrospectively compared 110 functional...
Background and Aim: This study aimed to determine the presence of concomitant extrahepatic autoimmune disease (EAD) in patients with liver (ALD) efficacy treatment response ALD any EAD. Material Methods: Between January 2001 November 2017, 241 were included study. Results: Of patients, 88, 134, 19 had hepatitis (AIH), primary biliary cholangitis (PBC), overlap syndrome (OS), respectively. Thirty-one cirrhosis: 77% 23% compensated decompensated disease, The at least one EAD was defined 38.6%...