Abstract Purpose The characteristics of patients with bilateral and unilateral breast cancer at the time diagnosis or during follow-up have been compared, focusing on differences in disease-free survival overall between these groups. Methods A total 1,947 diagnosed invasive carcinoma were included study. 1876 ​​(96.4%) our had 71 (3.6%) cancer. Among n = 47 metachronous, while 24 synchronous. Results SBBC, which lowest OS duration, showed a statistically significant difference compared to...

Abstract Purpose A high-fructose diet is supposed to induce the so-called metabolic syndrome, associated with increased fat deposition in adipose tissue. Physical exercise may counteract induction of syndrome. The present study aims investigate effect voluntary physical activity (VPA) on cGMP-mediated lipolysis retroperitoneal tissue a syndrome model induced rats by diet. Methods Male Sprague-Dawley control and fructose (F) groups had free access either plain drinking water or solution 20%...

1 Muscle injury (rhabdomyolysis) is one of the causes acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in pathogenesis glycerol-induced myoglobinuric ARF. l-Carnitine an anti-oxidant prevents accumulation end-products lipid peroxidation. Therefore, aim present study was to investigate effects l-carnitine on ARF induced by intramuscular (i.m.) hypertonic glycerol injection. 2 Sprague-Dawley rats were divided into three groups. Rats group (n = 8) given...

Lymphovascular invasion (LVI) is an important prognostic factor in various solid tumors, however, data on the association between LVI and thyroid carcinomas are limited. In this study, we evaluated relationship clinicopathological features of papillary carcinoma (PTC). Six hundred seventy-eight patients diagnosed with PTC 2012 2015 were included into study. Patients classified based presence or absence LVI. Gender, age, ultrasonography (US), tumor size multifocality, BRAFV600E mutation,...

<p><strong>Aim <br /></strong>BRAF mutation inhibits many tumour suppressor genes, increases pro-angiogenic molecules and reduces radioactive iodine uptake of in papillary thyroid cancer (PTC), giving it more aggressive clinical characteristics. In this study, we aimed to evaluate the effect BRAF V600E on clinicopathological features patients with PTC. /><strong>Methods<br /></strong> The...

Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance glucose, lipid protein metabolism. However, it unclear whether these peptides may exert effects on renal damage, tissue remodeling, inflammatory conditions. In view of the limited information, we aimed to investigate effect matrix metalloproteinase response genes rat model adenine-induced chronic failure. failure was induced in...

Background: To evaluate the performance of TBSRTC through multi-institutional experience in paediatric population and questioning management recommendation ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted 4 institutions to identify consecutive thyroid FNAC cases between 2000 2018. Following 2nd TBSRTC, risk malignancy ratios (ROMs) given ranges calculated by 2 different ways. Sensitivity, specificity, PPV, NPV DA were using histologic...

Purpose The literature contains different information about the prognosis of invasive lobular carcinoma breast cancer (BC). We aimed to address inconsistency by comparatively examining clinical features and patients in our university report experience dividing into various subgroups. Patients methods Records with BC admitted Trakya University School Medicine Department Oncology between July 1999 December 2021 were reviewed. divided three groups (No-Special Type BC, Invasive Lobular Special...

Background: Gastrointestinal stromal tumors (GIST) have KIT or platelet-derived growth factor receptor α (PDGFRα) mutations affecting tyrosine kinase activity and do not benefit from classic treatment regimens. Aims:The aim of this study was to review the algorithm that may be followed for diagnosis differential in GISTs by investigating histomorphological parameters expression characteristics classical immunohistochemical antibodies used routine tests addition DOG1 expression.Study Design:...

Athletes misuse recombinant human growth hormone (r‑hGH) to enhance their performance. Although r‑hGH is known increase cardiac hypertrophy, the underlying molecular mechanism remains unclear. The aim of present study was investigate role in intracellular signaling pathways and miR‑21 miR‑133 expression rat hearts during exercise. A total 36 adult male Sprague‑Dawley rats were divided into sedentary control (SC, n=9), swimming exercise (SE, n=8), (GH, n=10) plus (SE‑GH, n=9) groups. groups...

Primary chondroid tumors of the larynx represent less than 1% all laryngeal tumors. Most them are chondromas and they often involve to cricoid cartilage. A 31-year-old male patient applied oto-laryngology service with a history dysphonia dyspnea. Microlaryngoscopy revealed 2 cm sized, ill-defined, covered regular mucosa, porous, hard mass on posterior surface crycoid cartilage in subglottic area. Following excision lesion, histopathologic examination as chondroma. Two years later, local...

Testicular cancer is a relatively rare tumor type, accounting for approximately 1% of all cancers in men. However, among men aged between 15 and 40 years, testicular the most commonly diagnosed malignancy. germ cell tumors (TGCTs) are classified as seminoma non-seminoma. The RAS oncogene controls several cellular functions, including proliferation, apoptosis, migration, differentiation. Thus, signaling important normal development. Mutations Kirsten (K-RAS) gene present over 20% cancers....

The aim of this study was to evaluate the relationship baseline fluorine-18-fluorodeoxyglucose PET/computed tomography (CT)-derived volumetric parameters for primary tumor with clinicopathological risk factors and molecular subtypes in patients invasive ductal breast carcinoma (IDBC).We evaluated 65 who underwent PET/CT initial cancer staging. association maximum mean standardized uptake values (SUVmax SUVmean, respectively), metabolic volume, total lesion glycolysis (TLG) investigated...

Purpose Clear cell renal cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated relationship between vascular endothelial growth factor (VEGF), HIF-1α, HIF-2α, p53 positivity, microvessel density, Ki-67 rates with prognostic histopathologic (Fuhrman nuclear grade, stage, sarcomatoid differentiation) survival in clear carcinomas. Material Methods Seventy-two nephrectomy...

Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 primary tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. This study assessed concordance on cells and infiltrating lymphocytes (TILs) CD8+ TIL intensity between tumors BMs from 24 NSCLC patients. PD-L1, CD3, CD8 positivity was determined by immunohistochemistry (IHC). scoring based proportion...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Tastekin E, Keskin EU, Can N, et al. CD56, CD57, HBME1, CK19, Galectin-3 and p63 immunohistochemical stains in differentiating diagnosis of thyroid benign/malign lesions NIFTP. Polish Journal Pathology. 2019;70(4):286-294. doi:10.5114/pjp.2019.93131. APA Tastekin, E., Keskin, E. U., Can, N., Canberk, S., Mut, A. & Erdogan, G. (2019). Pathology, 70(4), 286-294. https://doi.org/10.5114/pjp.2019.93131 Chicago...

Indomethacin is an anti-inflammatory drug with clearly known side effects on gastric mucosa. New treatment and effect prevention methods are being studied. Donkey milk, as a nutritional support, has recently come into the spotlight its anti-oxidant features, high antibody content low allergenic properties. In this study, we investigated donkey milk's possible protective against acute mucosal damage by indomethacin.Four groups, each composed of 8 rats, were created. Rats in first third groups...

Thyroid Bethesda Reporting System is a six-tiered system that aims to bring uniformity in reporting thyroid cytology and improve the communication with clinicians. The has achieved its goal as presurgical diagnostic method; however, it remains screening method grey zone categories, namely atypia of undetermined significance (AUS) follicular neoplasm (FN). book recently released 3rd edition, following recent changes pathology. One most important novelties subgrouping AUS category FN be able...

Abstract Introduction and Hypothesis The aim of this study was to compare the changes in hystomorphometry innervation anterior vaginal wall women with without prolapse. Methods Eighty‐nine biopsy specimens were obtained from having a cystocele repaired (stage ≥II; prolapse group, 49) same location patients no <II; control 40). Routine H&E staining immunohistochemical for protein gene product 9.5 (PGP‐9.5) smooth muscle α‐actin (SMA) performed all specimens. Results Number diameter...

Abstract Cytosine modifications at the 5-carbon position play a critical role in gene expression regulation and have been implicated cancer development. 5-Hydroxymethylcytosine (5hmC), arising from 5-methylcytosine (5-mC) oxidation, has shown promise as potential malignancy marker due to its depletion various human cancers. However, significance thyroid tumors remains underexplored, primarily limited data. In our study, we evaluated 5hmC levels by immunohistochemistry cohort of 318 tumors....