A5041119994- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Multiple Myeloma Research and Treatments
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Lung Cancer Treatments and Mutations
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Pediatric Pain Management Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- DNA Repair Mechanisms
- Muscle Physiology and Disorders
- Diverse Scientific Research Studies
- Biological Research and Disease Studies
- Protein Degradation and Inhibitors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
University of Central Florida
2023-2025
Florida College
2023-2025
University of Pittsburgh Medical Center
2022
UPMC Altoona
2022
Cleveland Clinic
2021-2022
Yale New Haven Hospital
2019-2021
University of Pittsburgh
2015-2016
Cairo University
2015-2016
Rates of colon cancer are much higher in African Americans (65:100,000) than rural South Africans (<5:100,000). The rates associated with animal protein and fat, lower fibre consumption, colonic secondary bile acids, short-chain fatty acid quantities mucosal proliferative biomarkers risk otherwise healthy middle-aged volunteers. Here we investigate further the role fat this association. We performed 2-week food exchanges subjects from same populations, where were fed a high-fibre, low-fat...
Oral squamous cell carcinoma (OSCC) is a serious public health problem caused primarily by smoking and alcohol consumption or human papillomavirus. The cancer stem (CSC) theory posits that CSCs show unique characteristics, including self-renewal therapeutic resistance. Examining biomarkers other features of critical to better understanding their biology. To this end, the results cellular SOX2 immunostaining correlates with CSC in OSCC lines marks rare population. assess whether division...
NPM1 mutated non-AML myeloid neoplasms (MN; <20% blasts) are characterized by an aggressive clinical course in a few studies. In this retrospective study, we evaluate the clinicopathologic and immunohistochemical features of MN patients with mutations. We assessed mutation targeted next generation sequencing (NGS). Cytoplasmic expression was immunohistochemistry (IHC) on formalin-fixed, formic acid-decalcified bone marrow biopsy specimens. evaluated 34 mutations comprising MDS (22), MPN (3)...
Establishing a diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (nLPHL) is often challenging as the differential broad, including classic (cHL), progressive transformation germinal centers (PTGC), and other lymphoproliferative disorders. In this study, we investigate utility recently described ultrasensitive in situ hybridization assay for kappa lambda immunoglobulin light chains distinguishing nLPHL, cHL, PTGC. A total 72 cases were examined (21 33 18 PTGC). large neoplastic...
Ultrasensitive RNA in situ hybridization for light chain is a relatively new diagnostic tool that aids the diagnosis of B‐cell lymphomas. The approach has been shown to be as sensitive flow cytometry assessing restriction.
Background: Osteosarcoma (OS), the most common primary malignant bone tumor, occurs mostly in pediatric and adolescent (P/A) population where it has been subject to intense study whereas OS arising older-aged adult undergone less scrutiny. Materials Methods: In this study, we assess molecular aberrations detected eight older patients (>59 years of age) with by whole-exome sequencing (WES) on formalin-fixed, paraffin-embedded tissue quantified contributions endogenous exogenous mutational...
A pathologist typically diagnoses tissue samples by examining glass slides under a light microscope. The entire specimen can be stored digitally as Whole Slide Image (WSI) for further analysis. However, managing and diagnosing large numbers of images manually is time-consuming requires specialized expertise. Consequently, computer-aided diagnosis these pathology an active research area, with deep learning showing promise in disease classification cancer cell segmentation. Robust models need...
In Brief Patients are younger and the disease is more resistant to treatment—severe cases can lead pseudomembranous colitis that may require a colectomy, sepsis, toxic megacolon, bowel perforation, death. Here's what you need know.
GENERAL COMMENTARY article Front. Cell Dev. Biol., 18 February 2015Sec. Stem Research Volume 3 - 2015 | https://doi.org/10.3389/fcell.2015.00011
Abstract Introduction: Oral squamous cell carcinoma (OSCC) is a serious public health problem, caused primarily by smoking and alcohol consumption. The prognosis remains poor due in part to therapeutic resistance. cancer stem (CSC) theory posits that oral stem-like cells (CSLCs) show unique characteristics, including self-renewal symmetric division tumor recapitulation asymmetric division. Identifying markers of CSLCs an important step better understanding the biology these cells....