A5018624210- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
- Synthesis of β-Lactam Compounds
- Childhood Cancer Survivors' Quality of Life
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Chemotherapy-induced cardiotoxicity and mitigation
- Graphene and Nanomaterials Applications
- Chemotherapy-related skin toxicity
- Tendon Structure and Treatment
- Alzheimer's disease research and treatments
- Analytical Methods in Pharmaceuticals
- Carbon Nanotubes in Composites
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Amino Acid Enzymes and Metabolism
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Tryptophan and brain disorders
- Acute Lymphoblastic Leukemia research
- Ocular Surface and Contact Lens
- Heavy Metal Exposure and Toxicity
- Pain Mechanisms and Treatments
- Nanoparticles: synthesis and applications
- Osteoarthritis Treatment and Mechanisms
October University of Modern Sciences and Arts
2021-2025
Minia University
2020
Abstract Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark many neurodegenerative disorders and aging. Deleteriously, the accumulation aberrant proteins in Alzheimer’s disease (AD) accompanied with marked collapse proteostasis network. The current study explored potential therapeutic effect vardenafil (VAR), phosphodiesterase-5 inhibitor, AlCl 3 / d -galactose ( -gal)-induced AD rats its possible underlying mechanisms. impact VAR treatment on neurobehavioral...
Among the independent risk factors for occurrence of cardiovascular diseases like atherosclerosis is hyperlipidemia. To decrease events and patient mortality, antihyperlipidemia therapy crucial. Our study aimed to enhance solubility poorly soluble lipid-lowering agent ezetimibe (EZ), a member class II as per Biopharmaceutics Classification System (BCS). The drug was formulated nanostructured lipid carrier (NLC) employing ultrasonication technique. A response surface D-optimal design employed...
The use of doxorubicin (DOX) to treat various tumors is limited by its cardiotoxicity. This study aimed investigate and compare the cardioprotective effects nicotinamide (NAM) alfacalcidol (1α(OH)D3), against DOX-induced Sprague Dawley male rats received DOX (5 mg/kg, i.p.) once/week for four consecutive weeks. Treated groups either NAM (600 p.o.) 28 days or 1α(OH)D3 (0.5 ug/kg, elicited marked cardiac tissue injury manifested elevated serum cardiotoxicity indices, conduction...
Abstract Purpose Up-to-date literature offers limited data about utilizing atorvastatin calcium (ATV) as a promising chondroprotective agent in osteoarthritis (OA). So, this study aims to develop depot intra-articular (IA) delivery system for ATV enhance its deposition the articular joint. Methods A 3 D-optimal design was implemented prepare ATV-loaded lecithin-coated zein nanoparticles. The optimized formulation (Opt-LCZN) selected and imaged using transmission electron microscope according...
Chronic kidney disease (CKD), a global health concern, is highly prevalent among adults. Presently, there are limited therapeutic options to restore function. This study aimed investigate the potential of breast milk mesenchymal stem cells (Br-MSCs) and their derived exosomes in CKD. Eighty adult male Sprague Dawley rats were randomly assigned one six groups, including control, nephropathy, nephropathy + conditioned media (CM), Br-MSCs, Br-MSCs (Br-MSCs-EXOs), Br-MSCs-EXOs. Before...
High dose methotrexate (HDMTX) is an important chemotherapy agent in the treatment of cancers children.Treatment with HDMTX can cause unwanted side effects and induces many types toxicity (e.g.renal toxicity, liver neurotoxicity, hematologic pulmonary gastrointestinal cutaneomucous toxicity).Adding leucovorin rescue provides advantage safe administration.However, therapy should be initiated only when plasma monitoring available to determine adequacy drug removal risk serious...