A5033937941- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
- Eicosanoids and Hypertension Pharmacology
- Regulation of Appetite and Obesity
- Extracellular vesicles in disease
- Sirtuins and Resveratrol in Medicine
- Amyotrophic Lateral Sclerosis Research
- Cancer-related cognitive impairment studies
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Natural Antidiabetic Agents Studies
- Diabetes Treatment and Management
- Genetic Neurodegenerative Diseases
- Dietary Effects on Health
- Gastrointestinal motility and disorders
University of Michigan–Ann Arbor
2022-2025
American University of Beirut
2017-2023
American University of Beirut Medical Center
2023
Ain Shams University
2014-2021
Diabetic dysbiosis has been described as a novel key player in diabetes and diabetic complications. However, the cellular/molecular alterations associated with remain poorly characterized. For that, control, non-obese type 2 MKR mice treated butyrate were used to delineate epigenetic, cellular molecular mechanisms by which induces colon shortening inflammation attesting gastrointestinal disturbance. Our results show that is T2DM characterized reduced Bacteroid fragilis population...
Abstract Background Peripheral neuropathy (PN) is a common complication in obesity, prediabetes, and type 2 diabetes, though its pathogenesis remains incompletely understood. In murine high-fat diet (HFD) obesity model of PN, dietary reversal (HFD-R) to low-fat standard (SD) restores nerve function the lipidome normal. As gut microbiome represents potential link between fat intake health, current study assessed shifts community structure by 16S rRNA profiling during paradigm various niches....
Abstract Amyotrophic lateral sclerosis (ALS) is a complex, fatal neurodegenerative disease. Disease pathophysiology incompletely understood but evidence suggests gut dysbiosis occurs in ALS, linked to impaired gastrointestinal integrity, immune system dysregulation and altered metabolism. Gut microbiome plasma metabolome have been separately investigated little known about microbe-plasma metabolite correlations, which could identify robust disease biomarkers potentially shed mechanistic...
Background: Peripheral neuropathy (PN), a complication of diabetes and obesity, progresses through complex pathophysiology. Lifestyle interventions to manage systemic metabolism are recommended prevent or slow PN, given the multifactorial risks obesity. A high-fat diet rich in saturated fatty acids (SFAs) induces which monounsaturated (MUFAs) rescues, independent weight loss, suggesting factors beyond impact nerve health. Interest has grown gut microbiome mechanisms is characterized by...
Abstract Schwann cells (SCs) support peripheral nerves under homeostatic conditions, independent of myelination, and contribute to damage in prediabetic neuropathy (PN). Here, we used single‐cell RNA sequencing characterize the transcriptional profiles intercellular communication SCs nerve microenvironment using high‐fat diet‐fed mouse, which mimics human prediabetes neuropathy. We identified four major SC clusters, myelinating, nonmyelinating, immature, repair healthy neuropathic nerves,...
Abstract Background Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to condition known as chemobrain. In fact, chemobrain is deteriorating adversely affects lives of cancer survivors. This study aimed examine potential therapeutic effects bone marrow mesenchymal stem cells (BMSCs) and their derived exosomes (BMSCs-Exo) DOX-induced rat models. Methods Chemobrain was induced by exposing rats DOX (2 mg/kg, i.p) once weekly for 4...
Diabetic kidney disease (DKD) is a serious complication of diabetes affecting millions people worldwide. Macrophages, critical immune cell type, are central players in the development and progression DKD. In this comprehensive review, we delve into intricate role macrophages DKD, examining how they can become polarized proinflammatory M1 or anti-inflammatory M2 phenotypes. We explore signaling pathways involved macrophage recruitment polarization kidneys, including key cytokines...
Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production. DUOX1 2 are NOX enzymes that require calcium for their activation which enters renal cells the pivotal TRPC channels. Hypoglycemic drugs such as liraglutide can interfere with this deleterious mechanism imparting reno-protection. Herein, we aim to investigate reno-protective effect of GLP1 receptor agonist (GLP1-RA), via its on TRPC6...
Cancer was recently annexed to diabetic complications. Furthermore, recent studies suggest that cancer can increase the risk of diabetes. Consequently, diabetes and share many factors, but cellular molecular pathways correlating colon rectal (CRC) remain far from understood. In this study, we assess effect hyperglycemia on cell aggressiveness in human epithelial adenocarcinoma cells vitro an experimental animal model CRC. Our results show Nox (NADPH oxidase enzyme) 4‐induced reactive oxygen...
Obesity is a growing global concern in adults and youth with parallel rise associated complications, including cognitive impairment. induces brain inflammation activates microglia, which contribute to impairment by aberrantly phagocytosing synaptic spines. Local systemic signals, such as inflammatory cytokines metabolites likely participate obesity-induced microglial activation. However, the precise mechanisms mediating activation during obesity remain incompletely understood. Herein, we...
Introduction Stem cells are a promising therapeutic in Alzheimer’s disease (AD) given the complex pathophysiologic pathways involved. However, mechanisms of stem remain unclear. Here, we used spatial transcriptomics to elucidate human neural (hNSCs) an animal model AD. Methods hNSCs were transplanted into fimbria fornix hippocampus using 5XFAD mouse model. Spatial memory was assessed by Morris water maze. Amyloid plaque burden quantified. performed and differentially expressed genes (DEGs)...
The identification and validation of a non-invasive prognostic marker for early detection diabetic kidney disease (DKD) can lead to substantial improvement in therapeutic decision-making. main objective this study is assess the potential role arachidonic acid (AA) metabolite 20-hydroxyeicosatetraenoic (20-HETE) predicting incidence progression DKD. Healthy patients with diabetes were recruited from Hamad General Hospital Qatar, urinary 20-HETE levels measured. Data analysis was done using...
Abstract Background Inhibitory interneurons normally regulate neural networks underlying memory and cognition, but are disrupted in Alzheimer’s disease. Proper interneuron activity reduces amyloid‐beta, whereas hyperexcitability elevates amyloid levels. Still, the pathologic processes mediating dysfunction remain unknown. Therefore, we employed a spatial transcriptomics approach to map transcriptomic profiles of temporal manner. Method Coronal hemibrain sections from early stage (12 wks)...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and leading cause of dementia, characterized by neuronal synapse loss, amyloid-β tau protein aggregates, multifactorial pathology involving neuroinflammation, vascular dysfunction, disrupted metabolism. Additionally, there growing evidence imbalance between excitation inhibition in the AD brain secondary to dysfunction parvalbumin (PV)- somatostatin (SST)-positive interneurons, which differentially modulate activity....