A5044541588- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Neuropeptides and Animal Physiology
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Diet, Metabolism, and Disease
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- PI3K/AKT/mTOR signaling in cancer
- Pharmacogenetics and Drug Metabolism
- Diabetes and associated disorders
- Chronic Kidney Disease and Diabetes
- Radiopharmaceutical Chemistry and Applications
- Metabolism, Diabetes, and Cancer
- Cholesterol and Lipid Metabolism
- Regulation of Appetite and Obesity
- Macrophage Migration Inhibitory Factor
- Diabetes Treatment and Management
- Cell Adhesion Molecules Research
University of Balamand
2022-2025
American University of Beirut Medical Center
2022-2025
American University of Beirut
2021-2024
Ohio University
2018-2024
University of Toledo
2015-2022
The role of insulin resistance in hepatic fibrosis Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes clearance to maintain sensitivity and repress de novo lipogenesis, as bolstered by the development steatohepatitis AlbuminCre + Cc1
The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood.This study aimed to clarify whether IDE is major mediator clearance, and define its the etiology hepatic resistance.We generated mice liver-specific deletion Ide (L-IDE-KO) assessed action.L-IDE-KO exhibited higher (~20%) fasting non-fasting plasma glucose levels, intolerance resistance. This phenotype was associated ~30% lower membrane receptor levels...
The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context aging, dysregulation can contribute epigenetic modifications aberrant states, accentuating senescence age-associated pathologies....
Abdominal obesity is a major risk factor for insulin resistance, type 2 diabetes and cardiovascular diseases. Dietary fat induces resistance in humans rodents. The current study investigates whether Chlorogenic acid/Chromium III supplement rescues caused by high-fat feeding of male C57BL/6 J mice 7 weeks. Administering an oral daily dose this the last 3 weeks reversed diet-induced body weight gain assessed hyperglycemia, glucose intolerance intolerance. Indirect calorimetry analysis revealed...
Diabetes is associated with decreased epoxyeicosatrienoic acid (EET) bioavailability and increased levels of glomerular vascular endothelial growth factor A (VEGF-A) expression. We examined whether a soluble epoxide hydrolase inhibitor protects against pathologic changes in diabetic kidney disease the inhibition VEGF-A signaling pathway attenuates diabetes-induced injury. also aimed to delineate cross talk between cytochrome P450 2C (CYP2C)–derived EETs VEGF-A. Streptozotocin-induced type 1...
Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in patients metabolic dysfunction-associated steatohepatitis (MASH). Global and hepatocyte-specific deletions of Ceacam1 impair insulin clearance to cause resistance steatosis. They also inflammation fibrosis, a condition characterized by excessive collagen production from activated stellate cells (HSCs). Given the positive effect PPARγ on transcription HSCs quiescence, current studies investigated whether loss causes...
Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production. DUOX1 2 are NOX enzymes that require calcium for their activation which enters renal cells the pivotal TRPC channels. Hypoglycemic drugs such as liraglutide can interfere with this deleterious mechanism imparting reno-protection. Herein, we aim to investigate reno-protective effect of GLP1 receptor agonist (GLP1-RA), via its on TRPC6...
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAMl), a substrate of the insulin receptor tyrosine kinase, regulates action by promoting clearance. Global null mutation Ceacam1 gene ( Cc1 −/− ) results in features metabolic syndrome, including resistance, hyperinsulinemia, visceral adiposity, elevated blood pressure, and albuminuria. It also causes activation renal renin-angiotensin system (RAS). In current study, we tested hypothesis that high-fat diet enhances expression RAS...
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin sensitivity by promoting hepatic clearance and mediating suppression of fatty acid synthase activity. Feeding C57BL/6J male mice with a high-fat (HF) diet for 3-4 weeks triggered >60% decrease in CEACAM1 levels to subsequently impair cause systemic resistance steatosis. This study aimed at investigating whether lipolysis drives reduction this constitutes key mechanism leading diet-induced metabolic...
Impairment of insulin clearance is being increasingly recognized as a critical step in the development resistance and metabolic disease. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes clearance. Null deletion or liver-specific inactivation Ceacam1 mice causes defect clearance, resistance, steatohepatitis, visceral obesity. Immunohistological analysis revealed reduction hepatic CEACAM1 obese subjects with fatty liver Thus, we aimed to determine whether this...
Exenatide, a glucagon-like peptide-1 receptor agonist, induces insulin secretion. Its role in clearance has not been adequately examined. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic to maintain sensitivity. Feeding C57BL/6J mice high-fat diet down-regulates Ceacam1 transcription cause hyperinsulinemia, resistance, and steatosis, as null (Cc1-/- ). Thus, we tested whether exenatide regulates expression diet-fed this contributes its sensitizing effect....
Mice with global null mutation of Ceacam1 (Cc1−/−), display impairment insulin clearance that causes hyperinsulinemia followed by resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability blood pressure. Liver-specific rescuing reversed all the metabolic abnormalities in Cc1−/−liver+ mice. The current study examined whether Cc1−/− male mice develop endothelial cardiac dysfunction this relates to caused defective...