A5043972352- Nuclear Structure and Function
- RNA Research and Splicing
- Cardiac Fibrosis and Remodeling
- Sulfur Compounds in Biology
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
- Pharmacological Receptor Mechanisms and Effects
- Pulmonary Hypertension Research and Treatments
- Aortic aneurysm repair treatments
- Sphingolipid Metabolism and Signaling
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Intracranial Aneurysms: Treatment and Complications
- Redox biology and oxidative stress
- DNA Repair Mechanisms
- Biotin and Related Studies
- Adipose Tissue and Metabolism
- Aortic Disease and Treatment Approaches
- Muscle Physiology and Disorders
- Inflammasome and immune disorders
- Amino Acid Enzymes and Metabolism
- Exercise and Physiological Responses
- Cardiovascular Disease and Adiposity
- Calcium signaling and nucleotide metabolism
- Endoplasmic Reticulum Stress and Disease
Zayed University
2024
Lebanese University
2022
Institut Mondor de Recherche Biomédicale
2007-2018
Inserm
2006-2011
Université Paris-Est Créteil
2007-2011
Background The tripeptide glutathione (L-gamma-glutamyl-cysteinyl-glycine) is essential to cell survival, and deficiency in cardiac systemic relates heart failure progression remodelling animal models. Accordingly, we investigated blood levels patients of different functional classes with structural diseases. Methods Glutathione was measured using standard enzymatic recycling method venous samples obtained from 91 individuals, including 15 healthy volunteers 76 New York Heart Association...
The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context aging, dysregulation can contribute epigenetic modifications aberrant states, accentuating senescence age-associated pathologies....
Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is an anatomic and pathologic condition associated with muscular electrical dysfunction of the heart, often leading to heart failure-related disability. There currently no specific therapy available for patients that target molecular pathophysiology cardiomyopathy. We showed here increase in oxidative stress levels hearts mice carrying mutation, a decrease key cellular antioxidant glutathione...