A5064972779- Adenosine and Purinergic Signaling
- Helicobacter pylori-related gastroenterology studies
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Cancer Immunotherapy and Biomarkers
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Ion Transport and Channel Regulation
- Prenatal Substance Exposure Effects
- Metabolism, Diabetes, and Cancer
- Marine Toxins and Detection Methods
- PARP inhibition in cancer therapy
- Synthesis and Characterization of Heterocyclic Compounds
- Biomarkers in Disease Mechanisms
- Gut microbiota and health
- Inflammasome and immune disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
American University of Beirut
2019-2023
American University of Beirut Medical Center
2023
Diabetic dysbiosis has been described as a novel key player in diabetes and diabetic complications. However, the cellular/molecular alterations associated with remain poorly characterized. For that, control, non-obese type 2 MKR mice treated butyrate were used to delineate epigenetic, cellular molecular mechanisms by which induces colon shortening inflammation attesting gastrointestinal disturbance. Our results show that is T2DM characterized reduced Bacteroid fragilis population...
Diabetic kidney disease (DKD) is a serious complication of diabetes affecting millions people worldwide. Macrophages, critical immune cell type, are central players in the development and progression DKD. In this comprehensive review, we delve into intricate role macrophages DKD, examining how they can become polarized proinflammatory M1 or anti-inflammatory M2 phenotypes. We explore signaling pathways involved macrophage recruitment polarization kidneys, including key cytokines...
Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production. DUOX1 2 are NOX enzymes that require calcium for their activation which enters renal cells the pivotal TRPC channels. Hypoglycemic drugs such as liraglutide can interfere with this deleterious mechanism imparting reno-protection. Herein, we aim to investigate reno-protective effect of GLP1 receptor agonist (GLP1-RA), via its on TRPC6...
Youssef, Natalie; Noureldein, Mohamad; Moussawi, Sarah Al; Assaad Antoine Eid. Eid's Lab. Author Information
Youssef, Natalie; Noureldein, Mohamad; Ziyadeh, Fuad N.; Eid, Assaad Antoine Author Information