A5101531659- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Immune Cell Function and Interaction
- Protein purification and stability
- Advanced Nanomaterials in Catalysis
- Cancer Immunotherapy and Biomarkers
- Proteins in Food Systems
- Surfactants and Colloidal Systems
- Cancer-related molecular mechanisms research
- Quantum Dots Synthesis And Properties
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Immune cells in cancer
- Hydrogels: synthesis, properties, applications
- Sexual function and dysfunction studies
- Optical Imaging and Spectroscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Photoacoustic and Ultrasonic Imaging
- Advanced biosensing and bioanalysis techniques
- Biosimilars and Bioanalytical Methods
- Biomarkers in Disease Mechanisms
- Statistical Methods in Clinical Trials
Third Affiliated Hospital of Sun Yat-sen University
2020-2023
Sun Yat-sen University
2020-2023
Sichuan University
2022-2023
West China Hospital of Sichuan University
2023
St. John's University
2004-2022
Eye & ENT Hospital of Fudan University
2019-2020
People's Hospital of Kaizhou District
2020
Yangzhou University
2019
Guangdong Medical College
2018
Shaanxi Normal University
2017
Abstract An ideal tumor treatment is supposed to eliminate the primary and simultaneously trigger host antitumor immune responses prevent recurrence metastasis. Herein, a liposome encapsulating phosphoinositide 3‐kinase gamma (PI3K γ ) inhibitor IPI‐549 photosensitizer chlorin e6 (Ce6), denoted by LIC, prepared for colon cancer treatment. LIC internalized into CT26 cells generates reactive oxygen species (ROS) under laser irradiation cause immunogenic cell death, during which...
Background Onco-immunogenic molecule CD155 is overexpressed in various tumor microenvironments (TME) including colorectal cancer (CRC). Tumor-associated macrophages (TAMs) are the most abundant immune cells CRC TME and play a vital role progression metastasis. Most studies have focused on investigating of cell-specific progression, while contribution TAMs-specific still unknown. Here, we sought to investigate expression pattern TAMs its immunity progression. Methods patterns paratumor or...
A new class of highly fluorescent, photostable, and magnetic core/shell nanoparticles has been synthesized from a reverse microemulsion method. The obtained bifunctional nanocomposites were characterized by transmission electron microscopy (TEM), ultraviolet–visible (UV–vis) spectrometry, photoluminescence (PL) fluorescence in field. To further improve their biocompatibility, the silica-coated functionalized with amino groups. fluorescent composite (FMCNPs) had typical diameter 50 ± 5 nm...
Background: Surgery is considered to be a potentially curative approach for gastric cancer. However, most cases are diagnosed at very advanced stage the lack of typical symptoms in initial stage, which makes it difficult completely surgical resect tumors. Early diagnosis and precise personalized intervention urgent issues solved improving prognosis Herein, we developed an RGD-modified ROS-responsive multifunctional nanosystem near-infrared (NIR) imaging photothermal therapy (PTT) against...
In this study, hydrophilic high-luminescent magnetic nanocomposites (LMNCs) composed of both fluorescent clusters (quantum dots, QDs) and nanoparticles were synthesized. The exhibited high luminescence easily separated in an external field. LMNCs capped with streptavidin (SA), the SA on surface LMNC-SA composites was confirmed to be bioactive by competitive inhibition analytic methods. fabricated have potential application biolabelling, bioseparation, immunoassay pathogenic diagnosis.
Neurogenic erectile dysfunction (nED) is one of the most common and intractable postoperative complications rectal prostate cancer surgery sometimes accompanies patients lifelong. The transplantation stem cells has been proved a promising way for treatment. However, therapeutic efficacy severely impaired by excessive cell loss death poor accumulation in injury site along with traditional implantation strategy. Herein, an EPO-loaded multifunctional hydrogel was designed. hydrogels' adhesive...
The significance of monitoring transepithelial electrical resistance (TEER) value during the study on drug absorption through Caco-2 monolayers in Transwells was re-evaluated. TEER monitored before, during, and after Streptokinase (45 KD). Four enhancers—disodium ethylenediaminetetracetate (disodium EDTA), sodium cholate (NaC), taurocholate (NaTC), caprate along with α-hemolysin (a cell membrane pore-forming toxin)—were used to signify outcome this study. Modified trypan blue exclusion...
Early diagnosis and complete resection of the tumor is an important way to improve quality patients with gastric cancer. In recent years, near-infrared (NIR) materials show great potential in fluorescence-based imaging tumors. order realize a satisfied intraoperative fluorescence imaging, there are two pre-requirements. One obtain stabile agent relatively longer circulation time. The second make it good biocompatible specific targeting tumor. Here, we developed RGD-modified Distearyl...
Background: Histones play a vital role in the pathogenesis of sepsis. However, studies on histones and prognosis sepsis patients are scarce. This study aims to investigate relationship between other biomarkers Furthermore, we aim determine explore possibility using them as potential biomarker Methods: We performed prospective observational 136 patients. One hundred twenty-six had sepsis, 10 were enrolled healthy controls. Baseline blood samples collected for plasma histone H4, cardiac...