A5055616491- Air Quality and Health Impacts
- Noise Effects and Management
- Asthma and respiratory diseases
- Birth, Development, and Health
- Climate Change and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Breastfeeding Practices and Influences
- Health, Environment, Cognitive Aging
- Obesity, Physical Activity, Diet
- Toxic Organic Pollutants Impact
- Nutritional Studies and Diet
- Infant Development and Preterm Care
- Energy and Environment Impacts
- Air Quality Monitoring and Forecasting
- Allergic Rhinitis and Sensitization
- Maternal Mental Health During Pregnancy and Postpartum
- Fatty Acid Research and Health
- Child Nutrition and Feeding Issues
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Attention Deficit Hyperactivity Disorder
- Smoking Behavior and Cessation
- Child and Adolescent Psychosocial and Emotional Development
- Neonatal Respiratory Health Research
- Child Nutrition and Water Access
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2013-2022
Universitat Pompeu Fabra
2013-2022
Barcelona Institute for Global Health
2016-2022
Barcelona Biomedical Research Park
2021
Instituto de Salud Carlos III
2009-2020
Municipal Institute for Medical Research
2006-2020
Centre for Biomedical Network Research on Rare Diseases
2019
Hospital Del Mar
2011-2018
Centro de Investigación Biomédica en Red
2018
Hospital del Mar Research Institute
2013-2018
Air pollution is a suspected developmental neurotoxicant. Many schools are located in close proximity to busy roads, and traffic air peaks when children at school. We aimed assess whether exposure of primary school traffic-related pollutants associated with impaired cognitive development.We conducted prospective study (n = 2,715, aged 7 10 y) from 39 Barcelona (Catalonia, Spain) exposed high low pollution, paired by socioeconomic index; were tested four times (i.e., the 12-mo trajectories)...
Cross-sectional studies suggest an association between exposure to ambient air pollution and atherosclerosis. We investigated the outdoor quality progression of subclinical atherosclerosis (common carotid artery intima-media thickness, CIMT).We examined data from five double-blind randomized trials that assessed effects various treatments on change in CIMT. The were conducted Los Angeles area. Spatial models land-use used estimate home mean concentration particulate matter up 2.5 micrometer...
Background: Green spaces have been associated with improved physical and mental health; however, the available evidence on impact of green pregnancy is scarce.Objectives: We investigated association between surrounding greenness birth weight, head circumference, gestational age at delivery.Methods: This study was based 2,393 singleton live births from four Spanish cohorts (Asturias, Gipuzkoa, Sabadell, Valencia) located in two regions Iberian Peninsula distinct climates vegetation patterns...
<h3>Background</h3> Although women with severe non-allergic asthma may represent a substantial proportion of adults in clinical practice, gender differences the incidence allergic and have been little investigated general population. <h3>Methods</h3> Gender prevalence, reported diagnosis were 9091 men randomly selected from population followed up after 8–10 years as part European Community Respiratory Health Survey. The protocol included assessment bronchial responsiveness, IgE specific to...
Introduction: Dietary intake of specific nutrients or food groups during pregnancy could play a role in the risk asthma and atopy offspring, but dietary patterns have not been implicated. The authors evaluated impact maternal (during pregnancy) child adherence to Mediterranean diet on childhood. Methods: Women presenting for antenatal care at all general practices Menorca, island Spain, over 12 month period starting mid-1997 were recruited. 460 children included analysis after 6.5 years...
Summary Background There is growing evidence that n‐3 fatty acids have anti‐inflammatory properties and may modulate immune response. Dietary intake of these nutrients during pregnancy could play a role in the risk asthma atopy offspring. Methods Using data from cohort women (n=462) enrolled whose offspring were followed up to 6 years, we evaluated impact fish consumption on incidence asthma. was assessed by food frequency questionnaire (42 items) applied an interviewer. Results Thirty‐four...
Active maternal smoking during pregnancy has been associated with a higher risk of behavioural disorders in children, but few cohort studies measuring data prospectively have studied its specific effects on the cognitive abilities pre-schoolers.A birth was set up Menorca Island 1997 within Asthma Multicenter Infants Cohort Study. A total 420 (87% those eligible) children had complete for final analyses at age 4 years. Interviewer-administered questionnaires were completed by mothers third...
<h3>Abstract</h3> Recurrent cortical network dynamics plays a crucial role for sequential information processing in the brain. While theoretical framework of reservoir computing provides conceptual basis understanding recurrent neural computation, it often requires manual adjustments global parameters, particular spectral radius synaptic weight matrix. Being mathematical and relatively complex quantity, is not readily accessible to biological networks, which generally adhere principle that...
<h3>Background</h3> Effects of prenatal and postnatal exposure to air pollution on lung function at preschool age remain unexplored. We examined the association during specific trimesters pregnancy life with in preschoolers. <h3>Methods</h3> Lung was assessed spirometry preschoolers aged 4.5 years (n=620) participating INfancia y Medio Ambiente (INMA) cohort. Temporally adjusted land use regression (LUR) models were applied estimate individual residential exposures benzene nitrogen dioxide...
Abstract Aim: To determine whether prenatal exposure to hexachlorobenzene (HCB) has potential adverse effects on child's weight and body mass index (BMI) in a general population with no local pollution sources. Methods: Starting from mid 1997, all mothers presenting for antenatal Menorca were recruited. Subsequently, 482 children enrolled. HCB was measured cord blood. Weight height at birth age 6.5 years. Results: Children levels higher than 1.03 ng/mL blood 1.14 kg (0.38) heavier had BMI...
Prenatal exposure to bisphenol A (BPA) and phthalates may affect fetal growth; however, previous findings are inconsistent based on few studies.We assessed whether prenatal BPA was associated with growth in a Spanish birth cohort of 488 mother-child pairs.We measured eight [four di(2-ethylhexyl) phthalate metabolites (DEHPm), mono-benzyl (MBzP), three low-molecular-weight (LMWPm)] two spot-urine samples collected during the first third trimester pregnancy. We estimated curves for femur...
Acetaminophen is extensively used during pregnancy. But there a lack of population-representative cohort studies evaluating its effects on range neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure acetaminophen adversely associated with neurodevelopmental outcomes at 1 5 years age.This Spanish birth study included 2644 mother-child pairs recruited The proportion liveborn participants evaluated was 88.8% 79.9%, respectively. Use prospectively in two...
The available evidence of the effects air pollution and noise on behavioral development is limited, it overlooks exposure at schools, where children spend a considerable amount time.We aimed to investigate associations traffic-related pollutants (TRAPs) school schoolchildren.We evaluated 7-11 years age in Barcelona (Catalonia, Spain) during 2012-2013 within BREATHE project. Indoor outdoor concentrations elemental carbon (EC), black (BC), nitrogen dioxide (NO2) were measured schools two...
Although it has been hypothesized that fetal exposure to endocrine-disrupting chemicals may increase obesity risk, empirical data are limited, and is uncertain how early in life any effects begin.We explored whether prenatal several organochlorine compounds (OCs) associated with rapid growth the first 6 months of body mass index (BMI) later infancy.Data come from INMA (Infancia y Medio-Ambiente) Child Environment birth cohort Spain, which recruited 657 women pregnancy. Rapid during was...
BackgroundPrenatal exposure to endocrine-disrupting chemicals (EDCs) may induce weight gain and obesity in children, but the obesogenic effects of mixtures have not been studied.ObjectiveWe evaluated associations between pre- perinatal biomarker concentrations 27 EDCs child status at 7 years age.MethodsIn pregnant women enrolled a Spanish birth cohort study 2004 2006, we measured 10 phthalate metabolites, bisphenol A, cadmium, arsenic, lead two maternal pregnancy urine samples; 6...
The fetus depends on maternal thyroid hormones during pregnancy for normal brain development. Little is known about the effects of subclinical hypothyroidism and mild hypothyroxinemia neurodevelopment child.We evaluated a population-based birth cohort in Spain. A total 1761 children their mothers were included main analyses. Serum levels free thyroxine thyrotropin measured pregnant women. Mental psychomotor development was assessed using Bayley Scales Infant Development second year life.Low...
Recent epidemiological research suggests that short-term effects of particle matter (PM) in urban areas may preferentially be driven by fine fractions. Questions remain concerning the adverse health coarse particles generated noncombustion, traffic-related processes and mechanism action PM. Using a time-stratified case-crossover design, we investigated association between three independent size fractions, (PM10−2.5), intermodal (PM2.5−1), very PMs (PM1), outcomes, respiratory,...
Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health.We studied the association exposure during pregnancy first year life with respiratory illnesses, ear infections, eczema 12-18 months age in a Spanish birth cohort 2,199 infants.We obtained parentally reported information doctor-diagnosed lower tract infections (LRTI) parental reports wheezing, eczema, infections. We estimated individual exposures to nitrogen dioxide (NO(2)) benzene...
Introduction Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the of LC-PUFAs supply cognition. We aimed to: 1) determine whether maternal genetic variants FADS cluster ELOVL genes contribute differences LC-PUFA levels colostrum; 2) analyze these related child cognition; 3) assess children's modify...
Objective To investigate the association of maternal circulating 25‐hydroxyvitamin D3 [25( OH )D3] concentration with pregnancy and birth outcomes. Design Prospective cohort study. Setting Four geographical areas Spain, 2003–2008. Population Of 2382 mother–child pairs participating in IN fancia y Medio Ambiente ( INMA ) Project. Methods Maternal 25( )D3 was measured (mean [ SD ] 13.5 [2.2] weeks gestation). We tested associations Main outcome measures Gestational diabetes mellitus GDM ),...
Prenatal exposure to air pollutants has been suggested as a possible etiologic factor for the occurrence of autism spectrum disorder.We aimed assess whether prenatal pollution is associated with childhood autistic traits in general population.Ours was collaborative study four European population-based birth/child cohorts-CATSS (Sweden), Generation R (the Netherlands), GASPII (Italy), and INMA (Spain). Nitrogen oxides (NO2, NOx) particulate matter (PM) diameters ≤ 2.5 μm (PM2.5), 10 (PM10),...
Although previous studies have reported negative associations between exposure to air pollution and cognition, of the effects prenatal postnatal exposures in early childhood been limited.We sought assess role fine particulate matter ([Formula: see text]) during different windows may play children's cognitive development at school age.Within Brain Development Air Pollution Ultrafine Particles School Children (BREATHE) Project, we estimated residential [Formula: text] by land use regression...
Maternal diet during pregnancy might influence the development of childhood allergic disorders. The aim present study was to evaluate impact Mediterranean (MD) adherence on wheeze and eczema in first year life two population-based mother-child cohorts Spain Greece. We studied 1771 mother-newborn pairs from Spanish multi-centre 'INMA' (INfancia y Medio Ambiente) (Gipuzkoa, Sabadell Valencia) 745 'RHEA' Crete, symptoms were based criteria International Study Asthma Allergies Childhood....