A5052218111- Balance, Gait, and Falls Prevention
- Dementia and Cognitive Impairment Research
- Optical Imaging and Spectroscopy Techniques
- Cerebral Palsy and Movement Disorders
- Multiple Sclerosis Research Studies
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Non-Invasive Vital Sign Monitoring
- Stroke Rehabilitation and Recovery
- Effects of Vibration on Health
- Older Adults Driving Studies
- Aging and Gerontology Research
- Neural and Behavioral Psychology Studies
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Multisensory perception and integration
- Nutrition and Health in Aging
- Musculoskeletal pain and rehabilitation
- Neurobiology of Language and Bilingualism
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Long-Term Effects of COVID-19
- EEG and Brain-Computer Interfaces
- Fibromyalgia and Chronic Fatigue Syndrome Research
Albert Einstein College of Medicine
2016-2025
Yeshiva University
2016-2025
University of British Columbia
2024
The Bronx Defenders
2010-2023
Tel Aviv University
2021
Tel Aviv Sourasky Medical Center
2021
Rush University Medical Center
2014-2021
Drexel University
2016
Montefiore Medical Center
2013
Columbia University
2002-2007
Identifying quantitative gait markers of falls in older adults may improve diagnostic assessments and suggest novel intervention targets. We studied 597 aged 70 (mean age 80.5 years, 62% women) enrolled an aging study who received at baseline. Association speed six other (cadence, stride length, swing, double support, length variability, swing time variability) with incident fall rate was using generalized estimation equation procedures adjusted for age, sex, education, falls, chronic...
Identifying quantitative gait markers of preclinical dementia may lead to new insights into early disease stages, improve diagnostic assessments and identify preventive strategies.To examine the relationship parameters decline in specific cognitive domains as well risk developing older adults.We conducted a prospective cohort study nested within community based ageing study. Of 427 subjects aged 70 years with assessments, 399 were dementia-free at baseline.Over 5 follow-up (median 2 years),...
Despite growing evidence of links between gait and cognition in aging, cognitive risk assessments that incorporate motoric signs have not been examined. We sought to validate a new Motoric Cognitive Risk (MCR) syndrome identify individuals at high developing dementia. evaluated 997 community residing aged 70 older participating the Einstein Aging Study over median follow-up time 36.9 months. MCR was defined as presence complaints slow (one standard deviation below age- sex-specific speed...
The authors examined the relationship between cognition and gait velocity, performed with without interference, in elderly participants. Neuropsychological test scores from 186 cognitively normal elders were submitted to factor analysis that yielded 3 factors: Verbal IQ, Speed/Executive Attention, Memory. Regression analyses revealed these factors significant predictors of variance but varied as a function task condition. All predicted velocity interference. However, Attention Memory not IQ...
<h3>Objectives:</h3> Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia characterized by slow gait and complaints, in multiple countries, its association with dementia risk. <h3>Methods:</h3> Pooled MCR analysis individual data from 26,802 adults without disability aged 60 years older 22 cohorts 17 countries. We also examined incident impairment (Mini-Mental State Examination decline ≥4 points) associated 4,812 individuals baseline...
Background.Evidence suggests that gait is influenced by higher order cognitive and cortical control mechanisms. However, less known about the functional correlates of gait.
To conduct a systematic clinical and quantitative assessment of gait in older adults with mild cognitive impairment (MCI) syndromes.Cross-sectional.Einstein Aging Study, community-based longitudinal aging study.Fifty-four individuals amnestic MCI (a-MCI), 62 nonamnestic-MCI (na-MCI), 295 healthy controls identified from the Einstein Study participants.Comparison performance subjects subtypes that cognitively normal adults.Neurological gaits were more common a-MCI (31.5%, P=.008) but not...
The current study examined the relationship between cognitive function and falls in elders who did not meet criteria for dementia or Mild Cognitive Impairment (n=172).To address limitations of previous research, associations controlled confounding effects gait measures other risk factors.A neuropsychological test battery was submitted to factor analysis yielding three orthogonal factors (verbal IQ, Speed/Executive Attention, Memory).Single recurrent within last 12 months were evaluated.We...
<h3>Context</h3>Neuropsychological tests are used to predict and diagnose dementia. However, our knowledge, no studies date have examined whether within-person across-neuropsychological test variability predicts dementia.<h3>Objective</h3>To examine future dementia.<h3>Design</h3>The Einstein Aging Study (EAS) is a population-based longitudinal study of aging dementia located in Bronx County, New York. We Cox proportional hazards models using age as the time scale estimate hazard ratios...
Background.Attention and executive functions show strong associations with slow gait falls in seniors have been shown to be amenable cognitive remediation. However, remediation as a strategy improve mobility has not investigated.
<h3>Objective:</h3> To report incidence and risk factors for motoric cognitive syndrome (MCR), a newly described predementia characterized by slow gait complaints. <h3>Methods:</h3> We examined rates of MCR in 3,128 adults aged 60 years older, MCR- dementia-free at baseline, participating 4 US-based cohort studies. Hazard ratios (HRs) with 95% confidence intervals (CIs) the association modifiable were computed using Cox models. <h3>Results:</h3> Over median follow-up time 3.2 years, 823...
Motor impairments and cognitive dysfunction are common in multiple sclerosis (MS). We aimed to delineate the relationship between capacity upper lower motor function 211 MS patients, 120 healthy volunteers. Lower were assessed with Timed 25 Foot Walk (T25FW) Nine Hole Peg Test (NHPT) as implemented Multiple Sclerosis Functional Composite (MSFC). Subjects also underwent neuropsychological evaluation. Hierarchical linear regression analysis was conducted separately for groups T25FW NHPT...
Increased inflammatory activity and gait speed decline are common with aging, but the association between two is not well established. The objective of this study was to determine influence markers, interleukin-6 (IL-6), tumor necrosis factor alpha, on performance in older adults. We conducted cross-sectional longitudinal analyses 333 adults aged 70 (61% women) biomarker assessments identified from participants Einstein Aging Study, a community-based aging study. Gait velocity measured at...
Objectives To examine the validity of W alking hile T est ( WWT ), a mobility stress test, to predict frailty, disability, and death in high‐functioning older adults. Design Prospective cohort study. Setting Community sample. Participants Six hundred thirty‐one community‐residing adults aged 70 participating E instein A ging Study (mean follow‐up 32 months). High‐functioning status at baseline was defined as absence disability dementia normal walking speeds. Measurements Hazard ratios HR s)...
ABSTRACT We examined the effect of cognitive fatigue on Attention Networks Test (ANT). Participants were 228 non-demented older adults. Cognitive was operationally defined as decline in alerting, orienting, and executive attention performance over course ANT. Anchored a theoretical model implicating frontal basal ganglia circuitry core substrate fatigue, we hypothesized that would be observed only attention. Consistent with our prediction, significant but not alerting or orienting. In...
The current study critically assessed the relationship between cognitive functions and gait in nondemented older adults. Quantitative measures of (velocity, cadence, a coefficient variance stride length) were single dual-task conditions. Three factors captured domains Executive Attention, Verbal IQ, Memory. Linear regressions showed that Attention was related to velocity both walking However, Memory IQ also velocity. Cadence length mixed effects models costs largest followed by cadence...
Abstract Gait decline is common among older adults and a risk factor for adverse outcomes. Poor gait performance in dual‐task conditions, such as walking while performing secondary cognitive interference task, associated with increased of frailty, disability, death. Yet, the functional neural substrates that support locomotion are not well established. We examined connectivity velocity single‐ (normal pace walking) (walking talking) conditions using resting‐state Magnetic Resonance Imaging...