A5069536717- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Advanced MRI Techniques and Applications
- Folate and B Vitamins Research
- Gut microbiota and health
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Pituitary Gland Disorders and Treatments
- Cerebrovascular and genetic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Congenital Diaphragmatic Hernia Studies
- Neurogenetic and Muscular Disorders Research
- MicroRNA in disease regulation
- Amyotrophic Lateral Sclerosis Research
- Cardiovascular Health and Disease Prevention
- Atherosclerosis and Cardiovascular Diseases
- Neurological diseases and metabolism
First Affiliated Hospital of Anhui Medical University
2015-2025
Anhui Medical University
2015-2025
Xuzhou Medical College
2019
Jiangsu University
2019
Hefei First People's Hospital
2015
Peking University
2013
Peking University Third Hospital
2013
Gut microbiota dysbiosis is linked to Alzheimer's disease (AD), but our understanding of the molecular and neuropathological bases underlying such association remains fragmentary. Using 16S rDNA amplicon sequencing, untargeted metabolomics, multi-modal magnetic resonance imaging, we examined group differences in gut microbiome, fecal metabolome, neuroimaging measures, cognitive variables across 30 patients with AD, 75 individuals mild impairment (MCI), 61 healthy controls (HC). Furthermore,...
Abnormal structures in the cortical and subcortical regions have been identified vascular cognition impairment (SVCI). However, little is known about functional alterations SVCI, no study refers to connectivity prefrontal this context. The medial cortex (MPFC) an important region of executive network default mode network, thalamus plays vital roles mediating or modulating these two networks. To investigate both thalamus- MPFC-related as well its relationship with 32 SVCI patients 23 control...
White matter hyperintensities (WMHs) of presumed vascular origin are one the most important neuroimaging markers cerebral small vessel disease (CSVD), which closely associated with cognitive impairment. The aim this study was to elucidate pathogenesis WMHs from perspective inflammation and hypoperfusion mechanisms. A total 65 patients healthy controls were enrolled in study. Inflammatory measurements [hypersensitive C-reactive protein (hsCRP) lipoprotein-associated phospholipase A2...
Cerebral small vessel disease (CSVD) is a chronic systemic degenerative affecting blood vessels in the brain, leading to cognitive impairments. Transcranial direct current stimulation (tDCS), non-invasive brain technique that applies low electrical currents scalp, shows promise treating and movement disorders. However, further clinical evaluation required assess long-term effects of tDCS on neuroplasticity gait patients with CSVD. We investigated long-term, repeated local perfusion, network...
Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims establish relationship and direction insulin cognition, while also quantifying mediating role brain cortical structure in this association. The publicly available data sources for (fasting insulin, homeostasis model assessment beta-cell function resistance, proinsulin), structure, cognitive phenotypes (visual memory, reaction time) were obtained...
BACKGROUND Young adults with minor ischemic stroke (MIS) often experience early onset and mild symptoms but face a high recurrence rate. Research into risk factors etiology of young adult MIS in developing countries is limited. We investigated these aspects non-cardiogenic patients from the Chinese Han population identified for initial long-term poor prognosis. MATERIAL AND METHODS Data aged 18 to 50 years healthy control group at The First Affiliated Hospital Anhui Medical University Third...
Intracranial aneurysms (IAs) are relatively common cerebrovascular anomalies. Melatonin could modulate inflammatory and offers neuroprotective effects, its role in IA has not been fully elucidated. An elastase-induced mouse model was constructed melatonin (150 mg/kg) administered to investigate therapeutic effects on IA. Aneurysm formation observed by bromophenol blue gelatin perfusion, the pathology changes mice were examined using hematoxylin-eosin (HE) staining. The potential mechanisms...
The incidence of minor ischemic stroke (MIS) and associated cognitive impairment is rising, particularly among younger individuals. Thus, both primary secondary prevention strategies are essential. This study investigated the risk factors for cerebral artery stenosis (CAS) in patients with MIS classified as large atherosclerosis (LAA) by TOAST, examined relationship between function plasma lipoprotein-associated phospholipase A2 levels. We conducted a retrospective analysis 789 admitted to...
Background: The relationship and mechanisms between body mass index (BMI) cognition are complex inconclusive. Additionally, the role of neuronal calcium dysfunction, reflected by cerebrospinal fluid (CSF) Visinin-like protein 1 (VILIP-1), in linked with BMI Alzheimer's disease (AD) has not been investigated. Objective: To investigate CSF VILIP-1, BMI, AD pathologies non-demented elderly at early stages AD. Methods: Baseline core biomarkers (amyloid-β 42 [Aβ ], phosphorylated tau [P-tau],...
The study aims to explore how microRNA-146a/b (miR-146a/b) regulates the function of endothelial progenitor cells (EPCs) in acute ischemic stroke mice. Eighty male SPF C57BL/6J mice were evenly divided into model-6 h, model-12 model-24 h (mice suffered from middle cerebral artery occlusion [MCAO] for 6 12 and h) normal groups. EPCs transfected assigned control, MCAO, MCAO-miR-146a, MCAO-miR-146b MCAO-miR-146a/b qRT-PCR was used detect miR-146a/b expression EPCs. Expressions tumor necrosis...
Abstract Background To date, the relationship between thyroid dysfunction and subcortical ischemic vascular disease ( SIVD )‐induced cognitive impairments still remains elusive. Methods Cognitive performances were examined in 215 participants, including 54 healthy 52 patients with no dementia SIVDND ), 55 mild impairment SVMCI VD ). Serum thyroid‐stimulating hormone TSH total triiodothyronine TT 3), free FT thyroxine 4) 4), thyroglobulin antibody TGA antithyroid peroxidase TPO ‐Abs)...
Gait disturbances are important clinical features of cerebral small vessel disease (CSVD) that increase the risk falls and disability. Brain structural alterations gait in CSVD patients have been well demonstrated. However, intrinsic resting function patterns with disorders remain largely unknown. Fifty-eight were enrolled our studies categorized into disorder group (CSVD-GD, n = 29) no-gait (CSVD-NGD, based on a examination. was quantitatively assessed Timed Up Go test intelligent device...
To investigate the topological properties of functional connectivity and their relationships with cognition impairment in subcortical vascular cognitive (SVCI) patients, resting-state fMRI graph theory approaches were employed 23 SVCI patients 20 healthy controls. Functional between 90 brain regions was estimated using bivariate correlation analysis thresholded to construct a set undirected graphs. Moreover, all them subjected battery assessment, correlations metrics performance further...
Patients who survive critical illness commonly suffer cognitive impairments. We aimed to study the effects of intervention treat long-term impairments observed among different populations intensive care unit (ICU) survivors. The results showed that significantly suppressed deterioration function in these patients. Medical and neurological ICU survivors were more susceptible than post-anaesthesia patients severe damage. In former, can be slowed by intervention. comparison, exerted positive on...
Both Alzheimer's disease (AD) and cerebral small vessel (CSVD) manifest in cognitive impairment gait disorders. The precise similarities differences characteristics underlying neuroimaging mechanisms remain unclear.
The primary manifestations of Alzheimer's disease (AD) include cognitive decline and brain gray matter volume (GMV) atrophy. Recent studies have found that plasma phosphorylated-tau (p-tau) concentrations perform better in diagnosing, differentiating, monitoring the progression AD. However, correlation between p-tau, GMV, cognition remains unclear.To investigate whether GMV plays a mediating role association p-tau cognition.In total, 99 participants (47 patients with AD 52 cognitively...
Intracranial aneurysm (IA) is a common cerebrovascular disease. The immune mechanism of IA more complicated, and it unclear so far. Therefore, necessary to continue explore the related molecular IA.All data were downloaded from public database. Limma package ssGSEA algorithm was used identify differentially expressed mRNAs (DEmRNAs) analyze cell infiltration, respectively. Machine learning cytoscape-cytohubba plug-in key types multicentric DEmRNAs IA, Multicentric cells screened out as by...
BACKGROUND This study aimed to investigate the diagnostic values of serum levels Hcy and UA for predicting vascular mild cognitive impairment (VMCI) in patients with cerebral small vessel disease (SVD). MATERIAL AND METHODS We selected 172 SVD divided them into a VMCI group non-VMCI group. Eighty-six healthy individuals without nervous system diseases were as control Enzymatic cycling method was performed detect levels. Serum folic acid (FOA) vitamin B12 (VitB12) detected by...
The aim of this study was to investigate the changes in cerebral blood flow velocity (CBFV) and its relation apolipoprotein E (apoE) epsilon4 allele mild cognitive impairment (MCI). Thirty MCI 30 controls were assessed using Mini-Mental State Examination (MMSE) Cambridge Cognitive Examination-Chinese version (CAMCOG-C), then insonated anterior (ACA), middle (MCA) basilar (BA) arteries transcranial Doppler ultrasonography. Compared with controls, showed significant decreases mean (V(m)),...
Abstract Background Inflammatory myofibroblastic tumor (IMT) and some types of immunoglobulin (Ig) G4‐related disease are often involved in the spectrum inflammatory pseudotumor (IPT) concept IgG4‐related IPT/IMT has recently been proposed. Methods A 38‐year‐old man complained initial symptoms blurred vision headache. Results was found right mastoid, which caused occlusion sigmoid sinus intracranial hypertension. diagnosis IMT with IgG4+ plasma cell infiltration established by surgical,...