A5100420743- Alzheimer's disease research and treatments
- Tea Polyphenols and Effects
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Neurological Disease Mechanisms and Treatments
- Sleep and related disorders
- Food Quality and Safety Studies
- Maternal and Perinatal Health Interventions
- Acupuncture Treatment Research Studies
- Histone Deacetylase Inhibitors Research
- Bone fractures and treatments
- Spine and Intervertebral Disc Pathology
- Cardiac electrophysiology and arrhythmias
- Migraine and Headache Studies
- Lipid metabolism and disorders
- Magnetism in coordination complexes
- Cholinesterase and Neurodegenerative Diseases
- Emergency and Acute Care Studies
- Flavonoids in Medical Research
- Sinusitis and nasal conditions
- Cervical and Thoracic Myelopathy
- Bacterial biofilms and quorum sensing
- Nosocomial Infections in ICU
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
Central South University
2014-2025
Anhui Medical University
2022-2025
Third Xiangya Hospital
2025
Shantou University
2023-2024
Shantou University Medical College
2023-2024
Shantou University Mental Health Center
2023-2024
Second Xiangya Hospital of Central South University
2014-2024
Jiangsu Academy of Agricultural Sciences
2024
Chinese Academy of Sciences
2005-2024
Conemaugh Health System
2024
Withering is an important processing stage in green tea, which contributes to the tea flavor quality. The aim of this work was comprehensively investigate changes chemical features and attributes Longjing teas produced with five different withering degrees (moisture content 75.05, 72.53, 70.07, 68.00, 64.78%, w.b.). Combined human sensory evaluation, electronic tongue chromatic differences analysis, assessment relationship between degree quality obtained. By using a non-targeted metabolomics...
Two homotrinuclear cobalt(<sc>ii</sc>) complexes with different solvent molecules that coordinate to the central Co(<sc>ii</sc>) ion, show supramolecular interactions and exhibit catalytic activities in relation catechol oxidase.
Abstract The IGF1 signal pathway is highly activated in some subtype of gastric cancer(GC) that exhibits poor survival and chemotherapy resistance. Although the results clinical trials anti-IGF1R monoclonal antibodies IGF-1R inhibitors have been mostly disappointing unselected cancer patients, patients benefit from therapy these failed studies. Therefore, it necessary to characterize complex IGF signaling GC help refine strategies targeting pathway. We found cell lines exhibit differential...
Abstract Heat shock proteins (HSPs) are a cardioprotective class of induced by stress and regulated the transcription factor, heat factor (HSF)-1. 17β-estradiol (E2) indirectly regulates HSP expression through rapid activation nuclear factor-κB (NF-κB) HSF-1 protects against hypoxia. As males experience loss protective cellular responses in aging, we hypothesized that aged menopausal (old ovariectomized) rats would have an impaired response, which could be prevented immediate vivo E2...
Although previous studies have demonstrated allostatic load (AL) predicts depressive symptoms, few considered the association between AL and trajectories of symptoms. This study aims to systematically examine associations abnormal blood biomarkers in three biological systems with A total 6251 participants aged 45+ from China Health Retirement Longitudinal Study (CHARLS). Depressive symptoms were assessed using 10-item Center for Epidemiological Studies Depression Scale (CESD-10) five visits...
Intracranial aneurysms (IAs) are relatively common cerebrovascular anomalies. Melatonin could modulate inflammatory and offers neuroprotective effects, its role in IA has not been fully elucidated. An elastase-induced mouse model was constructed melatonin (150 mg/kg) administered to investigate therapeutic effects on IA. Aneurysm formation observed by bromophenol blue gelatin perfusion, the pathology changes mice were examined using hematoxylin-eosin (HE) staining. The potential mechanisms...
As a neurodegenerative disease, Alzheimer's disease (AD) seriously affects the health of older people. Changes in synapses occur first over course perhaps even before formation Aβ plaques. Histone deacetylase (HDAC) mediates damage oligomers to dendritic spines. Therefore, we examined relationship between HDAC activity and synaptic defects using an inhibitor (HDACI), BG45, human neuroblastoma SH-SY5Y cell line with stable overexpression Swedish mutant APP (APPsw) APP/PS1 transgenic mice...
In adult myocardium, excitation-contraction coupling is critically regulated by sarcoplasmic reticulum (SR) Ca2+ release via type 2 ryanodine receptor (RyR2), but generally, it believed that SR-function rudimentary in the fetal heart and embryonic stem (ES) cell-derived cardiomyocytes (ESCMs), a possible source for cell replacement therapies. This study used wild-type (RyR2+/+) RyR2 null (RyR2-/-) ESCMs as an vitro model of cardiomyogenesis, together with pharmacological approaches...
Background: High cholesterol aggravates the risk development of Alzheimer's disease (AD). AD is closely related to transport impairment Amyloid-β (Aβ) in blood-brain barrier. It unclear whether high affects cognitive by affecting Aβ transport. The purpose study investigate regulates through low-density Lipoprotein Receptor-Related Protein 1 (LRP1) and Receptor for Advanced Glycation End products (RAGE) AD. Methods: We established mice model. learning memory functions were evaluated Morris...
β-amyloid (Aβ) is an important protein molecule in the pathology of Alzheimer’s disease (AD). Accumulation Aβ leads to loss dendritic spines and synapses. These impairments can be ameliorated by histone deacetylase inhibitors (HDACI). However, mechanisms HDACIs underlying effect on synapse are not fully understood. In this study, we examined relationship between HDAC activity synapse-related genes proteins administration a class I inhibitor, BG45, exogenous Aβ-treated cells mice. Our studies...
Summary Insomnia with objective short sleep duration has been proposed as the most biologically severe phenotype of disorder associated cardiometabolic morbidity in population‐based samples. In this study, we investigated association between insomnia and hypertension a large clinical sample. We studied 348 patients diagnosed chronic based on International Classification Sleep Disorders Third Edition criteria 150 normal sleepers. Objective was defined by median total time sample (< 7 hr)...
Calcific aortic valve disease (CAVD) and osteoarthritis (OA) are common diseases in the ageing population share similar pathogenesis, especially inflammation. This study aims to discover potential diagnostic therapeutic targets patients with CAVD OA. Three datasets one OA dataset were obtained from Gene Expression Omnibus database. We used bioinformatics methods search for key genes immune infiltration, established a ceRNA network. Immunohistochemical staining was performed verify expression...
Cardioprotection by intermittent high-altitude (IHA) hypoxia against ischemia-reperfusion (I/R) injury is associated with Ca(2+) overload reduction. Phospholamban (PLB) phosphorylation relieves cardiac sarcoplasmic reticulum (SR) Ca(2+)-pump ATPase, a critical regulator in intracellular cycling, from inhibition. To test the hypothesis that IHA increases PLB and such an effect plays role cardioprotection, we compared time-dependent changes at Ser(16) (PKA site) Thr(17) (CaMKII perfused...
The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 environmental risk factors type 2 diabetes mellitus (T2DM) in Hohhot. explored different models gene-environment interactions, aimed at providing approaches for prevention control T2DM combination with characteristics local population.A case-control conducted including 406 Chinese participants, comprising 203 cases controls from various...
Alzheimer’s disease (AD) is a common neurodegenerative disease. Abundant evidence demonstrates that oxidative stress may be not only an early event in this disease, but also key factor the pathogenesis of AD. Ginkgo biloba extract (EGb) has strong ability to scavenge oxygen free radicals and supply hydrogen. The present study aims investigate effects EGb on Neuro 2A cells transfected with Swedish mutant APP (APPsw). Stably cell lines expressing human wild-type (APP695), APPsw, or empty...
Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) lacunar infarcts (LI) to risk Alzheimer's disease (AD) in an elderly cohort China.Methods Older adults who were initially cognitively normal examined with MRI at baseline, followed for 5 years.WMH classified as mild, moderate, or severe, LI into a few (1 3) many (≥4).Cognitive function was assessed using Mini Mental State Examination Activities Daily Living scale.Results Among 2,626...
Abstract Background Currently, the association of nutritional risk screening score with development nonventilator hospital-acquired pneumonia (NV-HAP) is unknown. This study investigated whether an independent predictor NV-HAP. Methods retrospective cohort was conducted between September 2017 and June 2020 in a tertiary hospital China. The tool Nutritional Risk Screening 2002 (NRS-2002) used for screening. A total ≥3 indicated patient “at risk.” Logistic regression applied to explore NRS...