A5071131738- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Gut microbiota and health
- Advanced MRI Techniques and Applications
- Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Anesthesia and Neurotoxicity Research
- Folate and B Vitamins Research
- Cerebrospinal fluid and hydrocephalus
- Balance, Gait, and Falls Prevention
- Nanocluster Synthesis and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and disorders
- Genetic Associations and Epidemiology
- Intensive Care Unit Cognitive Disorders
- Studies on Chitinases and Chitosanases
- Cardiac tumors and thrombi
- Brain Metastases and Treatment
First Affiliated Hospital of Anhui Medical University
2021-2025
Anhui Medical University
2021-2025
Riverview Medical Center
2020
White matter hyperintensities (WMHs) of presumed vascular origin are one the most important neuroimaging markers cerebral small vessel disease (CSVD), which closely associated with cognitive impairment. The aim this study was to elucidate pathogenesis WMHs from perspective inflammation and hypoperfusion mechanisms. A total 65 patients healthy controls were enrolled in study. Inflammatory measurements [hypersensitive C-reactive protein (hsCRP) lipoprotein-associated phospholipase A2...
BACKGROUND Young adults with minor ischemic stroke (MIS) often experience early onset and mild symptoms but face a high recurrence rate. Research into risk factors etiology of young adult MIS in developing countries is limited. We investigated these aspects non-cardiogenic patients from the Chinese Han population identified for initial long-term poor prognosis. MATERIAL AND METHODS Data aged 18 to 50 years healthy control group at The First Affiliated Hospital Anhui Medical University Third...
Both Alzheimer's disease (AD) and cerebral small vessel (CSVD) manifest in cognitive impairment gait disorders. The precise similarities differences characteristics underlying neuroimaging mechanisms remain unclear.
Abstract White matter hyperintensities (WMHs) of presumed vascular origin are important imaging biomarkers cerebral small vessel disease (CSVD). Previous studies have verified abnormal functional brain networks in CSVD. However, most these rely on static connectivity, and only a few focus the varying severity WMHs. Hence, our study primarily explored disrupted dynamic network connectivity (dFNC) topological organization variance patients with This included 38 moderate WMHs, 47 severe 68...
The pathogenesis of Alzheimer's disease is complex, and early-onset (EOAD) mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with PSEN2 mutation being rarest. In this study, we reported a 56-year-old Chinese Han proband who presented prominent progressive amnesia, aphasia, executive function impairment, depression 5 years ago. 3-year follow-up showed that...
Previous research has focused on static functional connectivity in gait disorders caused by cerebral small vessel disease (CSVD), neglecting dynamic connections and network attribution. This study aims to investigate alterations (dFNC) topological organization variance CSVD-related disorders.
The identification of risk factors for recurrence in patients with minor ischemic stroke (MIS) is a critical medical need.To develop nomogram individualized prediction in-hospital MIS patients.Based on retrospective collection, single-center study was conducted at the First Affiliated Hospital Anhui Medical University from January 2014 to December 2019. Univariate and multivariate logistic regression analyses were used determine associated recurrence. least absolute shrinkage selection...
Subcortical ischemic vascular disease (SIVD) is one of the important causes cognitive dysfunction, altered amyloid-beta (Aβ) and cerebral perfusion may be involved in pathophysiological mechanism SIVD are closely related to function. We aimed investigate serum Aβ patients with their correlation Seventy-four healthy controls (HCs) 74 patients, including 38 no impairment (SIVD-NCI) 36 mild (SIVD-MCI) underwent measurement Aβ40 Aβ42 levels, pseudo-continuous arterial spin labeling MRI scanning,...
Abstract Chitinase-3-like protein-1 (YKL-40) is recognized as a novel neuroinflammatory biomarker related to neurodegenerative diseases. We aimed explore whether serum YKL-40 can serve potential in patients with cerebral small vessel disease (CSVD), and possible neural correlates white matter fiber damage cognitive impairment. Blood samples were collected from 100 CSVD 80 healthy controls (HCs) measure levels. All subjects underwent diffusion tensor imaging (DTI) scanning function...
Abstract Background Oxidized low-density lipoprotein (ox-LDL), as a biomarker for atherosclerosis, is closely related to the occurrence and development of cerebrovascular diseases such acute cerebral infarction caused by vascular stenosis. White matter hyperintensities (WMHs) presumed origin, one most important neuroimaging markers small vessel disease(CSVD), associated with inflammation chronic ischemia. Methoeds : Our objective determine whether ox-LDL concentration was change blood flow...