A5100318909- Chronic Obstructive Pulmonary Disease (COPD) Research
- Prostate Cancer Treatment and Research
- Crystallization and Solubility Studies
- Radiopharmaceutical Chemistry and Applications
- X-ray Diffraction in Crystallography
- Respiratory Support and Mechanisms
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Treatments and Mutations
- Cerebrovascular and Carotid Artery Diseases
- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Photodynamic Therapy Research Studies
- Aortic Disease and Treatment Approaches
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Skin Protection and Aging
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Diagnosis and Treatment
- Phagocytosis and Immune Regulation
Tianjin Medical University Cancer Institute and Hospital
2025
University of Shanghai for Science and Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Peking Union Medical College Hospital
2018-2024
Hefei University of Technology
2024
Liaoning Cancer Hospital & Institute
2009-2023
China Medical University
2021-2023
Beijing Normal University
2023
First Affiliated Hospital of Zhengzhou University
2023
First Affiliated Hospital of Anhui Medical University
2020-2022
Predicting the response to neoadjuvant chemoimmunotherapy in patients with resectable non-small cell lung cancer (NSCLC) facilitates clinical treatment decisions. Our study aimed establish a machine learning model that accurately predicts pathological complete (pCR) using 18F-FDG PET radiomics features. We retrospectively included 210 NSCLC who completed and subsequently underwent surgery results, categorising them into training set of 147 test 63 patients. Radiomic features were extracted...
Cyclooxygenase-2 (COX-2) participates in cancer invasion and metastasis by decreasing the expression of E-cadherin. However, molecular mechanisms through which COX-2 regulates E-cadherin function have not yet been fully elucidated. The aim this study was to investigate possible gastric cancer. mRNA protein COX-2, nuclear factor-κB (NF-κB), Snail detected cells quantitative PCR western blot analysis, respectively. these genes also healthy mucosa tissues immunohistochemistry. We various levels...
RUNX3 (runt-related transcription factor-3) is a known tumor suppressor gene which exhibits potent antitumor activity in several carcinomas. However, little about the role of human renal cell carcinoma (RCC). To investigate clinical relevance RCC patients, immunohistochemistry was performed to detect 75 tissues and paired non-cancerous by using tissue microarray (TMA). We also investigated migration, invasion angiogenesis. The expression decreased dramatically tissue. significantly...
Purpose Modifying glucagon-like peptide-1 receptor (GLP-1R)–targeted PET agent to achieve faster renal clearance and preserved high affinity GLP-1R is clinically relevant. The aim of this study assess the performance a newly developed GLP-1R–targeted agent, 68 Ga-HBED-CC-exendin-4 in localizing insulinoma, its biodistribution, as compared with previously introduced Ga-NOTA-exendin-4. Patients Methods Nineteen patients endogenous hyperinsulinemic hypoglycemia were enrolled referred for PET/CT...
Bufei Jianpi granules has been confirmed effective in improving pulmonary function, alleviating acute exacerbations, six-minute walk distance and quality of life, benefited 12-month follow-up chronic obstructive disease (COPD) patients with syndrome lung-spleen qi deficiency. Skeletal muscle dysfunction (SMD), an important extrapulmonary complication, occurs the very initiation COPD is closely related to morbidity mortality. To evaluate efficacy on SMD, we observed skeletal muscular function...
Purpose We aimed to compare the diagnostic performance of 68 Ga-P16-093 and Ga-PSMA-617 PET/CT in primary prostate cancer (PCa) patients. Patients Methods Thirty untreated PCa patients were enrolled. Each patient underwent within a week. In addition visual analysis, SUV was measured for semiquantitative comparison correlation analysis. Results detected more positive tumors than (67 vs 56, P = 0.002), especially intraprostatic lesions (29 24, 0.025) lymph node metastases (23 17, 0.034)....
The integrated therapy of Bufei Yishen granule and acupoint sticking has been used in the treatment stable chronic obstructive pulmonary disease (COPD) clinically, with remarkable benefits. This study was initiated to observe effects combination on function morphormetry a COPD rat model.
Paclitaxel (PTX) is a widely used anticancer drug that works by inhibiting microtubule disassembly. PTX safety was greatly enhanced embedding it with human albumin. Here, we study the synergistic effects of photodynamic therapy (PDT) both in vitro and vivo constructing photosensitizer–PTX nanotheranostics (PPNTs). PPNTs were fabricated via noncovalent hydrophobic interactions π–π stacking between an amphipathic photosensitizer average diameter ∼80 nm, these showed high stability biological...
Purpose: Chronic bronchitis (CB), emphysematous (EM) and asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) phenotypes in COPD are well recognized. This study aimed to investigate distinguishing characteristics of these patients with frequent exacerbations (FE). Patients methods: A retrospective was carried out. acute were consecutively reviewed from November 2015 October 2016. divided into FE infrequent (iFE) subgroups. Results: total 142 eligible subjects reviewed....
Our previous studies have demonstrated the beneficial effects of Bufei Yishen granules combined with acupoint sticking therapy (the integrated therapy) in chronic obstructive pulmonary disease (COPD), but underlying mechanism remains unclear. Dysfunction surfactant proteins (SPs, including SP-A, SP-B, SP-C, and SP-D) may be included pathophysiology COPD. This study aimed to explore on SPs. COPD rat models were established. The treatment groups received or their combination. Using...
Background: The deletion of exon 19 and the Leu858Arg mutation 21 are most frequently observed mutations in epidermal growth factor receptor (EGFR) gene, patients with these have shown significant benefits from EGFR-tyrosine kinase inhibitors (TKIs). However, there exists a small subgroup uncommon/rare EGFR, including compound mutations, which display high degree heterogeneity terms clinical features variable sensitivities to EGFR-TKIs. understanding uncommon their response targeted therapy...
Objective: To explore the relationships between serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and KIM-based white matter lesion (WML) carotid atherosclerotic plaque. Methods: From November 2018 to July 2019, 155 patients admitted Department of Neurology First Affiliated Hospital Anhui Medical University were enrolled, with 125 cases brain MRI manifestations lesions allocated WML group 30 normal in control (NC group). According KIM classification, further divided into...
Integrin α v β 3 is overexpressed in various tumor cells and angiogenesis. To date, no drug has been proven to target it for therapy. A first-in-human study was designed investigate the safety, pharmacokinetics, dosimetry of 177Lu-AB-3PRGD2, a novel integrin 3-targeting radionuclide with an albumin-binding motif optimize pharmacokinetics. Ten patients (3 men, 7 women; aged 45 ± 16 years) 3-avid tumors were recruited accept 177Lu-AB-3PRGD2 injection dosage 1.57 0.08 GBq (42.32 2.11 mCi),...