A5101890337- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Soft tissue tumor case studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Myasthenia Gravis and Thymoma
- Dermatologic Treatments and Research
- Urologic and reproductive health conditions
- Cancer Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Tumors and Oncological Cases
- Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
National University of Singapore
2024-2025
Target (United States)
2021-2023
Rationale: Early discovery, accurate diagnosis, and staging of lung cancer is essential for patients to receive appropriate treatment.PET/CT has become increasingly recognized as a valuable imaging modality these patients, but there remains room improvement in PET tracers.We aimed evaluate the feasibility using [ 68 Ga]Ga-FAPI-RGD, dual-targeting heterodimeric tracer that recognizes both fibroblast activation protein (FAP) integrin αvβ3 detecting neoplasms, by comparing it with 18 F]FDG...
Purpose: Lower-grade gliomas (LGGs) are a group of infiltrative growing glial brain tumors characterized by intricate intratumoral heterogeneity and subtle visual appearance differences from non-tumor tissue, which can lead to errors in pathologic tissue sampling.Although 5-ALA fluorescence has been an essential method for visualizing during surgery, its effectiveness is limited the case LGGs due low sensitivity.Therefore, we developed novel PET/NIR dual-modality image probe targeting...
This study was designed to assess the safety and therapeutic response <sup>177</sup>Lu-labeled Evans blue–modified prostate-specific membrane antigen (PSMA) 617 (EB-PSMA-617) treatment with escalating doses in patients metastatic castration-resistant prostate cancer. <b>Methods:</b> With institutional review board approval informed consent, were randomly divided into 3 groups: group A (<i>n</i> = 10) treated a 1.18 ± 0.09 GBq dose of <sup>177</sup>Lu-EB-PSMA. Group B 2.12 0.19 C 8) 3.52 0.58...
We aimed to investigate the safety and therapeutic efficacy of radioligand therapy (RLT) <sup>177</sup>Lu-EB-prostate-specific membrane antigen (PSMA) in patients with metastatic castration-resistant prostate cancer. <b>Methods:</b> Thirty men progressive cancer previously treated taxane-based chemotherapy second-generation androgen deprivation were enrolled. All received up 3 cycles approximately 2.0 GBq (55 mCi) <sup>177</sup>Lu-EB-PSMA per cycle at 8-wk intervals. The primary endpoint was...
The emerging combination of chemotherapy and radionuclide therapy has been actively investigated to overcome the limitations monotherapy augment therapeutic efficacy. However, it remains a challenge design single delivery vehicle that can incorporate chemotherapeutics radionuclides into compact structure. Here, chelator DOTA- or NOTA-modified Evans blue conjugated camptothecin molecule (EB-CPT) nanoprodrug was synthesized, which could self-assemble nanoparticles due its inherent...
Purpose The aim of this study was to investigate the value 68 Ga-NOTA-RM26 ( Ga-RM26), a gastrin-releasing peptide receptor–targeting antagonist labeled with radionuclide Ga, in diagnosis high-grade gliomas and combination multiregional biopsies using PET/CT. Patients Methods After institutional review board approval informed consent, total 35 patients suspected glioma lesions were enrolled study. All underwent Ga-RM26 PET/CT scans within 2 weeks before surgery. Results There 8 grade II...
Gliomas are the most common malignant primary tumors of central nervous system. There is an urgent need for new convenient, targeted and specific imaging agents gliomas. This study aimed to firstly evaluate feasibility 68Ga-NOTA-RM26 PET/CT in glioma analyze relationship between characteristics grade, classification molecular alterations. Twenty-two patients were confirmed as by surgery or biopsy. All exhibited uptake. SUVmax was chosen marker analysis. For all patients, there significant...
Abstract Primary pulmonary mucosa–associated lymphoid tissue lymphoma is extremely rare. We present the 18 F-FDG and 68 Ga-FAPI PET/CT findings in a 56-year-old woman with pathologically confirmed primary lymphoma. showed higher uptake value than lesion. This case suggests that may be sensitive alternative method to characterize low-grade lymphomas.
Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade non-Hodgkin that extremely rarely localises to the mediastinum. A 34-year-old female with chronic arthralgia, sicca and rash was found have a well-demarcated mediastinal cystic mass equivocal nodular enhancement within wall on chest CT during workup for Sjögren's syndrome. Subsequent 68Ga-Pentixafor-PET/CT revealed focal uptake increase capsule. The patient underwent thoracoscopic resection of lesion, pathology MALT...
Purpose: This study was designed to evaluate 68 Ga-pentixafor, which targets C-X-C chemokine receptor 4 (CXCR4), in the noninvasive diagnosis of thymomas. Patients and Methods: With institutional review board approval signed informed consent, 32 patients with thymic masses were enrolled this study, all underwent Ga-pentixafor PET/CT scans. Results: Among 28 included analysis, 13 diagnosed thymomas, 9 cysts, 6 other anterior mediastinal masses. identified thymomas (13/13, 100%), mean SUV max...
Solitary fibrous tumor (SFT) is a rare sarcoma of mesenchymal origin. Although generally benign, SFTs carry the risk recurrence and metastasis, with limited effective treatment options. The aims this study are to compare performance fibroblast activation protein inhibitor (FAPI), [68Ga]Ga-DOTA-FAPI-04 (denoted as [68Ga]Ga-FAPI-04), conventional [18F]FDG PET/CT in patients recurrent or metastatic head preliminarily explore value FAP-targeted radiopharmaceutical therapy 177Lu for SFT patients....
This study aimed to evaluate the safety and efficacy of multiple cycles <sup>177</sup>Lu-DOTA-Evans blue (EB)-TATE peptide receptor radionuclide therapy (PRRT) at escalating doses in neuroendocrine tumors (NETs). <b>Methods:</b> Thirty-two NET patients were randomly divided into 3 groups treated with doses. Group A received 1.17 ± 0.09 GBq/cycle; group B, 1.89 0.53 C, 3.97 0.84 GBq/cycle. The treatment was planned for up cycles. Treatment-related adverse events graded according National...
Rationale: This study aimed to assess the safety, efficacy, and survival of 177Lu-DOTA-EB-TATE in patients with metastatic neuroendocrine tumors (NETs).Methods: Thirty NETs were prospectively enrolled treated (3 intended cycles at 8 12-week intervals, 3.7 GBq/cycle). Treatment-related adverse events graded according National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. The treatment response was RECIST 1.1 PERCIST 1.0 criteria. Kaplan-Meier analysis...
Gastrointestinal stromal tumors (GISTs) are the most common in gastrointestinal tract. This study was designed to evaluate a gastrin-releasing peptide receptor antagonist PET tracer, [
Purpose Modifying glucagon-like peptide-1 receptor (GLP-1R)–targeted PET agent to achieve faster renal clearance and preserved high affinity GLP-1R is clinically relevant. The aim of this study assess the performance a newly developed GLP-1R–targeted agent, 68 Ga-HBED-CC-exendin-4 in localizing insulinoma, its biodistribution, as compared with previously introduced Ga-NOTA-exendin-4. Patients Methods Nineteen patients endogenous hyperinsulinemic hypoglycemia were enrolled referred for PET/CT...
Due to the temporal and spatial heterogeneity of human epidermal growth factor receptor 2 (HER2) expression in breast tumors, immunohistochemistry (IHC) cannot accurately reflect HER2 status real time, which may cause misguided treatment decisions. HER2-specific imaging can noninvasively determine primary metastatic tumors. In this study, cancer patients was determined vivo by SPECT/CT 99mTc-HP-Ark2, comparing with PET/CT 18F-FDG lesion lesion.A novel HER2-targeted peptide probe...
In recent years, significant improvement has been made in the management of non-small cell lung cancer (NSCLC), primarily driven by advances targeted therapy and immunotherapy. Research on neoadjuvant also experienced considerable development, directed towards NSCLC harboring epidermal growth factor receptor or anaplastic lymphoma kinase mutations. Nevertheless, there remains a dearth studies investigating context BRAF (V-Raf murine sarcoma viral oncogene homolog B) V600E mutant NSCLC....
Purpose Keloids are benign fibroproliferative disorders characterized by the massive proliferation of fibroblasts. Fibroblast activation plays a key role in invasive growth keloids. Therefore, prospective pilot study was conducted to explore value 68 Ga-FAPI-04 PET/CT assessment keloids activity. Patients and Methods Twenty-five patients with keloid were enrolled conduct PET/CT. All accepted surgery remove part lesions within 1 week. SUV mean max measured for semiquantitative analysis...