A5102707164- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- AI in cancer detection
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
- Global Cancer Incidence and Screening
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Cancer and Skin Lesions
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Peking Union Medical College Hospital
2007-2025
Zhejiang Chinese Medical University
2025
Academy of Medical Sciences
2023
ORCID
2022
Ningbo First Hospital
2019
Abstract Background Intercellular communication is crucial for breast cancer progression and metastasis. However, the role of cancer-derived exosomes their microRNA (miRNA) cargoes mediating intercellular requires further investigation. Methods Cancer-derived were isolated using differential centrifugation differentially expressed miRNAs determined by microarrays qRT-PCR analysis. Cell proliferation, wound-healing, Transwell invasion, tumor xenograft assays used functional research. Plasma...
Abstract Drug and xenobiotic metabolizing enzymes (DXME) play important roles in drug responses carcinogenesis. Recent studies have found that expression of DXME cancer cells significantly affects clearance the onset resistance. In this study we compared breast tumor tissue samples from patients representing three ethnic groups: Caucasian Americans (CA), African (AA), Asian (AS). We further combined gene data with eQTL GTEx project allele frequency 1000 Genomes to identify SNPs may be...
Abstract Background Ultrasound is more widely used than mammography for early diagnosis of breast cancer in China as most Chinese women have small and dense mammary glands. This study compared the diagnostic performance ultrasound among with suspected lesions. Methods From November 2019 to 2021, we results lesion 2737 consecutive participants lesions; all patients underwent biopsies. We measured sensitivity, specificity, accuracy separately. Results Among participants, 2844 lesions were...
Introduction The US plays a crucial role in screening Asian women for breast disease. ABUS offers several advantages over traditional HHUS, including quicker examination, objectivity, and the ability to store reconstruct images. This study marks first large-scale opportunistic of population. Methods Between January 1, 2016, December 31, 2019, 10,537 aged 35–75 years from nine districts were randomly assigned either HHUS or groups. Diagnostic methods quantified, comparisons made using...
Calreticulin (CALR) preserves reticular homeostasis by maintaining correct protein folding within the endoplasmic reticulum. Immunogenic cell death (ICD) is a regulated form of and could activate adaptive immune response. As one damage-associated molecular patterns during ICD process, surface-exposed CALR resulted in activation Here, we evaluated expression cohort 231 untreated triple-negative breast cancer (TNBC) determined correlations between clinicopathologic parameters, programmed...
Abstract Long noncoding ribonucleic acids (LncRNAs) have been found to be involved in the proliferation, apoptosis, invasion, migration, and other pathological processes of triple-negative breast cancer (TNBC). Expression lncRNA actin filament-associated protein 1 antisense RNA1 (AFAP1-AS1) has significantly higher TNBC than subtypes or normal tissue samples, but specific mechanism by which AFAP1-AS1 affects occurrence development is yet revealed. In this study, we used Cell Counting Kit-8...
Given the limited access to breast cancer (BC) screening, authors developed and validated a mobile phone-artificial intelligence-based infrared thermography (AI-IRT) system for BC screening.This large prospective clinical trial assessed diagnostic performance of AI-IRT system. The constructed two datasets models, performed internal external validation, compared accuracy AI models clinicians. Dataset A included 2100 patients recruited from 19 medical centres in nine regions China. B was used...
This study aimed to describe the clinical characteristics of periductal mastitis (PDM), propose practical classification system and evaluate results different surgical treatments in type PDM patients.A retrospective was carried out at department breast surgery, Peking Union Medical College Hospital, Beijing, China. A total 152 patients with diagnosis were reviewed from March 2012 December 2016. All underwent surgery. Data collected regarding manifestation, treatment, outcomes.The median age...
Objectives The contribution of ultrasound-assisted thoracic paravertebral block to postoperative analgesia remains unclear. We compared the effect a combination ultrasound assisted-thoracic and propofol general anesthesia with opioid sevoflurane on volatile anesthetic, consumption, pain in patients having breast cancer surgery. Methods Patients undergoing surgery were randomly assigned (PPA group, n = 121) or fentanyl (GA 126). Volatile intensity between groups using noninferiority...
Abstract Background A better diagnostic marker is in need to distinguish breast cancer from suspicious lesions. The abnormal glycosylation of haptoglobin has been documented assist diagnosis. This study aims evaluate disease-specific (DSHp)-β N-glycosylation as a potential biomarker for Methods DSHp-β chains 497 patients with lesions who underwent surgery were separated serum immunoinflammatory-related protein complexes. was quantified by mass spectrometric analysis. After missing data...
Due to the temporal and spatial heterogeneity of human epidermal growth factor receptor 2 (HER2) expression in breast tumors, immunohistochemistry (IHC) cannot accurately reflect HER2 status real time, which may cause misguided treatment decisions. HER2-specific imaging can noninvasively determine primary metastatic tumors. In this study, cancer patients was determined vivo by SPECT/CT 99mTc-HP-Ark2, comparing with PET/CT 18F-FDG lesion lesion.A novel HER2-targeted peptide probe...
Tall cell carcinoma of the breast with reverse polarity (TCCRP), described firstly and also known as tall variant papillary (TCVPBC), is a rare type cancer that mimics thyroid (PTC) histopathologically. As incidence this tumor very low, awareness it crucial to ensuring unnecessary clinical investigations are avoided. The present study examined 45-year-old woman in China who was diagnosed TCCRP. This paper outlines her demographic clinicopathologic data, follow-up immunohistochemical...
The long non-coding RNA (lncRNA) actin fiber-associated protein-1 antisense 1 (AFAP1-AS1) exerted oncogenic activity in triple-negative breast cancer (TNBC). We designed this study and conducted it to investigate the upstream regulation mechanism of AFAP1-AS1 TNBC tumorigenesis. In work, we proved localization cytoplasm. elucidated by which transcription factor specificity protein (SP1) modulated progression, has yet be thoroughly studied. Dual luciferase reporter assay chromatin...
Background: The breast epithelial cells in patients with triple-negative cancer (TNBC) actually have specific estrogen receptor (ER) expression, and the abnormal glycosylation of UGT1A1 TNBC resulted expression function ERα through regulating modification ERα. Therefore, our study targets role then (estrogen α) resistance development TNBC. Methods: differential mRNA miRNA tissues was tested. Luciferase activity analyzed treated miR-452. Moreover, human mammary gland cell lines were dealt...
It is well known that different racial groups have significantly incidence and mortality rates for certain cancers. has been suggested biological factors play a major role in these cancer disparities. Previous studies on the contributing to disparity generated very large number of candidate factors, although there modest agreement among results studies. Here, we performed an integrative analysis using genomic data 21 types from TCGA, GTEx, 1000 Genomes Project identify cancer. We also built...
BCSC‐1 is dramatically upregulated in CNE‐2L2 human nasopharyngeal carcinoma cells with reduced malignancy (AS cells) and proposed to be a candidate tumor suppressor gene. We therefore examined the effect of expression on malignant behaviors cells. Growth vitro tumorigenesis nude mice wild‐type (W were inhibited by ectopic , those AS promoted suppression. The function was further confirmed study showing that intratumor injection caused growth suppression from W inoculated mice....
Mammography is the principle imaging modality used for early diagnosis of breast cancer in Western countries. It has not been well-established whether this diagnostic adoptable Chinese women. The aim study was to evaluate respective accuracy common tools including history-taking, physical examination, ultrasound and mammography.Clinical presentation investigations consecutive patients undergoing ultrasound, mammography pathological assessment at Peking Union Medical College Hospital were...
The regimen of concurrent administration trastuzumab and anthracyclines in the adjuvant treatment breast cancer has never been evaluated prospectively for fear cardiac toxicity.Patients with HER2-positive operable were randomised to receive or sequential anthracyclines. Cardiac monitoring was scheduled at baseline every 3 months after first dose trastuzumab. primary study endpoint safety. Secondary endpoints disease-free overall survival.From 2011 2014, 201 participants enrolled randomised....
Abstract Background The de-escalation treatment in patients with low-risk HER2-positive early breast cancer (eBC) is an attractive strategy to avoid unnecessary and improve the quality of life patients. Pyrotinib, a novel irreversible pan-HER2 tyrosine kinase inhibitor (TKI), has shown efficacy advanced cancer. Meanwhile, nanoparticle albumin-bound (nab)-paclitaxel reveals survival benefit over solvent-based paclitaxel eliminates toxicities associated solvent. However, safety pyrotinib...
Abstract Background or Purpose A practical noninvasive method to identify sentinel lymph node (SLN) status in breast cancer patients, who had a suspicious axillary (ALN) at ultrasound (US), but negative clinical physical examination is needed. To predict SLN metastasis using nomogram based on US and biopsy‐based pathological features, this retrospective study investigated associations between clinicopathological features status. Methods Patients treated with dissection four centers were...