A5008933754- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Intraocular Surgery and Lenses
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Ocular Diseases and Behçet’s Syndrome
- Corneal Surgery and Treatments
- Neuropeptides and Animal Physiology
- Adenosine and Purinergic Signaling
- Cell death mechanisms and regulation
- Angiogenesis and VEGF in Cancer
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- melanin and skin pigmentation
- RNA Interference and Gene Delivery
- Advanced Glycation End Products research
- Hippo pathway signaling and YAP/TAZ
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Air Quality and Health Impacts
- Ophthalmology and Visual Impairment Studies
- COVID-19 and healthcare impacts
- Autophagy in Disease and Therapy
Jilin University
2010-2025
Jilin Province Science and Technology Department
2025
Albert Einstein College of Medicine
2025
University of California, San Francisco
2022-2024
Soochow University
2015-2024
City College of San Francisco
2024
San Francisco General Hospital
2023
Memorial Sloan Kettering Cancer Center
2016-2023
Johns Hopkins Medicine
2019-2022
Johns Hopkins University
2019-2022
Abstract Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found nearly all AMLs that harbor a mutation Nucleophosmin (NPM1) gene, concomitantly approximately 60% of these cases. Little known about how mutant NPM1 (NPM1mut) cells maintain aberrant gene expression. Here, we demonstrate histone modifiers MLL1 DOT1L control differentiation NPM1mut AML. Using CRISPR/Cas9 genome editing...
Choroidal neovascularization (CNV) is the leading cause of vision loss in many blinding diseases, but current antiangiogenic therapies with invasively intravitreal injection suffer from poor patient compliance and a rate devastating ocular complications. Here, we develop an alternative agent based on hybrid cell-membrane-cloaked nanoparticles for noninvasively targeted treatment CNV. The retinal endotheliocyte membrane coating provides as-fabricated nanoagents homotypic targeting capability...
Oxidative stress and inflammation are important pathogenic factors of diabetic retinopathy (DR). DR remains the most common ocular complication caused by diabetes mellitus (DM) is leading cause visual impairment in working-aged people worldwide. Melatonin has attracted extensive attention due to its potent antioxidant anti-inflammatory effects. In present study, melatonin inhibited oxidative enhancing expression activity silent information regulator factor 2-related enzyme 1 (Sirt1) both...
Autoimmunity significantly contributes to the pathogenesis of myocarditis, underscored by its increased frequency in autoimmune diseases such as systemic lupus erythematosus and polymyositis. Even cases myocarditis caused viral infections, dysregulated immune responses contribute pathogenesis. However, whether triggered existing conditions or precise antigens immunologic pathways driving remain incompletely understood. The emergence associated with checkpoint inhibitor therapy, commonly used...
WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription. However, oncogenic effect WDR5 leukemia remains largely unknown. Here, we found expression is increased patients. High associated with high risk leukemia; Patients and MLL1 have poor complete remission rate. We further identified global genomic binding leukemic cells co-localization H3K4me3 enrichment. Moreover, knockdown by shRNA suppresses cell...
Abstract Diabetic retinopathy (DR) is the most common ocular complication caused by diabetes mellitus and main cause of visual impairment in working‐age people. Reactive gliosis pro‐inflammatory cytokine production Müller cells contribute to progression DR. Melatonin a strong anti‐inflammatory hormone, mediating cytoprotective effect variety retinal against hyperglycemia. In this study, melatonin inhibited activation inflammatory both vitro vivo models The membrane blocker, Luzindole,...
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly and attributed to choroidal neovascularization (CNV), which feature wet AMD. The hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) pathway contributes pathogenesis CNV. M1-type macrophages/microglia secrete interleukin-6 (IL-6) tumor necrosis α (TNF-α), facilitating development Epigallocatechin-3-gallate (EGCG) kind polyphenol green tea that exerts...
Whirlin mutations cause retinal degeneration and hearing loss in Usher syndrome type II (USH2) non-syndromic deafness, DFNB31. Its protein recruits other USH2 causative proteins to form a complex at the periciliary membrane photoreceptors ankle link of stereocilia hair cells. However, biological function this is largely unknown. Using yeast two-hybrid screen, we identified espin, an actin-binding/bundling involved human deafness when defective, as whirlin-interacting protein. The interaction...
The cytotoxic effects of zeaxanthin on two human uveal melanoma cell lines (SP6.5 and C918) related signaling pathways were studied compared to normal ocular cells (uveal melanocytes, retinal pigment epithelial cells, scleral fibroblasts). MTT assay revealed that reduced the viability in a dose-dependent manner (10, 30, 100 μ M), with IC 50 at 40.8 28.7 M SP6.5 C918 lines, respectively. Zeaxanthin did not affect even highest levels tested (300 suggesting has selectively effect cells. induced...
To understand the prevalence, awareness, and risk factors for diabetic retinopathy (DR) among Chinese with known type-2 diabetes mellitus (T2DM) in eastern China communities.A community-based survey including 913 patients T2DM was conducted Suzhou, China. Diabetes defined as hemoglobin A1c (hbA1c) ≥6.5%, use of medication or a physician diagnosis diabetes. Retinal photographs were graded presence DR using Airlie House classification system. Binary logistic regression models established to...