A5101444599- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Crystallography and molecular interactions
- Data Stream Mining Techniques
- Treatment of Major Depression
- Higher Education and Teaching Methods
- Image Processing and 3D Reconstruction
- Functional Brain Connectivity Studies
- Advanced Computational Techniques and Applications
- 3D Shape Modeling and Analysis
- Plasma Applications and Diagnostics
- Online Learning and Analytics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Anomaly Detection Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Machine Learning and Data Classification
- Coronary Artery Anomalies
- Sulfur Compounds in Biology
- Network Security and Intrusion Detection
- Fuel Cells and Related Materials
- Educational Games and Gamification
- Robotics and Sensor-Based Localization
Tongji University
2011-2025
National Clinical Research Center for Digestive Diseases
2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Southern Medical University
2024
Central China Normal University
2004-2024
National University of Defense Technology
2024
Nanjing Forestry University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
West China Hospital of Sichuan University
2024
Ischemic stroke is a devastating disease and one of the leading causes mortality worldwide. Overproduction reactive oxygen nitrogen species (RONS) following ischemic insult known as key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production have great therapeutic potential. Herein, we propose an efficient treatment strategy which artificial nanozyme with multienzyme activity drives neuroprotection against primarily by scavenging RONS. Specifically,...
The role of M2 macrophages in the resolution and fibroproliferation acute lung injury (ALI) is poorly understood. In this study, we investigated effects two macrophage subtypes, M2a induced by interleukin (IL)-4/IL-13 M2c IL-10/transforming growth factor -β, on pathogenesis ALI. were adoptively transferred into lipopolysaccharide-induced ALI mice model. Data showed that Vybrant-labeled appeared lungs mice. Subsequently, observed both subsets significantly reduced inflammation including a...
Abstract Ischemic stroke (IS) is a leading cause of morbidity and mortality globally triggers series reactions to primary secondary brain injuries permanent neurological deficits. Microglia in the central nervous system play dual roles neuroprotection responding ischemic damage. Here, an IS model employed determine involvement microglia phagocytosis at excitatory synapses. Additionally, effects pharmacological depletion are investigated on improving neurobehavioral outcomes mitigating...
Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms PND are closely related to perineuronal nets (PNNs). PNNs, which complexes extracellular matrix primarily surrounding neurons the hippocampus, play critical role function. Connexin 43 (Cx43) contributes function by modulating components PNNs. This study was designed investigate specific regulatory Cx43 on PNNs its pivotal...
Acrostichum aureum Linn., a medicinal pteridophyte growing in mangrove forests and coastal regions of tropical subtropical areas worldwide, has been proved to possess various biological effects. However, the protective effect Linn. against gastric ulcer still remains unidentified. Therefore, gastroprotective water extract (WEAC) was investigated ethanol‐induced injury model. According our results, pretreatment with WEAC (100, 200, 400 mg/kg) could dramatically decrease ameliorate...
The perioperative neurocognitive disorder (PND) is a severe complication that affects millions of surgical patients each year. Homocysteine (Hcy) known to increase the risk developing PND in both young and elderly mice. However, whether Hcy alone can induce cognitive deficits middle-aged mice (12-month-old), exercise attenuate Hcy-induced hippocampus-related after surgery through suppressing neuroinflammation, synaptic elimination, level remains unknown. present study aimed answer these...
Late embryogenesis abundant (LEA) proteins are involved in diverse abiotic stresses tolerance many different organisms. Our previous studies have shown that the heterologous expression of OsLEA1a interfered with resistance Escherichia coli to stresses. However, present study, based on growth status and physiological indices rice plant, overexpression conferred increased compared wild-type (WT) plants. Before applying stresses, there were no significant differences seedlings. After NaCl,...
To evaluate the clinical efficacy and safety of transcatheter closure (TCC) in patients with ruptured sinus Valsalva aneurysm (RSVA).RSVA is a rare cardiovascular disease varied presentation. The TCC for RSVA still remain an ongoing concern.From January 2009 to March 2013, 22 were selected TCC. Intracardiac pressure size cardiac chamber measured before post All followed up by transthoracic echocardiography at 1, 3, 6, 12 months after procedure.RSVA was successfully occluded 20 (19 cases...
Aging is one of the greatest risk factors for postoperative cognitive dysfunction (POCD), also known as perioperative neurocognitive disorder (PND). Animal models PND are usually induced in mice over 18 months age, which imposes expensive economic and time costs PND-related studies. Sleep disorders, including sleep fragmentation, reported to aggravate memory impairment neurocognitive-related diseases such Alzheimer's disease (AD). Therefore, aim present study was explore whether a model...
Recommender systems support user decision-making, and explanations of recommendations further facilitate their usefulness. Previous explanation styles are based on similar users, items, demographics contents items. Contexts, such as usage scenarios accompanying persons, have not been used for explanations, although they influence decisions. In this paper, we propose a context style method, presenting contexts suitable consuming recommended The expected impacts 1) persuasiveness: recognition...
A comparative study of laser induced damage HfO2/SiO2 and TiO2/SiO2 mirrors at 1064 nm has been carried out. One mirror with absorption 300 ppm two 40 4.5 were fabricated using electron beam evaporation method. For r-on-1 test, all low average are above 150 J/cm2 10 ns. However, the high just 9.5 J/cm2, which probably due to rather band gap energy. Meanwhile, samples irradiated from front back side respectively raster scan test mode. In case irradiation, it is found that: for reflectors,...
ABSTRACT We recently reported that CD4 + CD25 regulatory T cells (Tregs) contributed to the recovery of patients with acute lung injury (ALI) by upregulating cell immunoglobulin and mucin-domain containing-3 (Tim-3). However, molecular mechanism which Tim-3 regulates Tregs’ function in resolution fibroproliferation after ALI remains unknown. In this study, we adoptively transferred Tregs or − into lipopolysaccharide -induced mice model. Data demonstrated not only decreased indices...
Abstract The catalytic synthesis of cyclic nitrones, an important type functional molecules for both synthetic chemistry and related fields, remains underdeveloped. Herein we report the copper‐catalyzed Cope‐type hydroamination oximes with pendant nonactivated olefins, which enables facile access to a series five‐ six‐membered nitrones under mild conditions. In this study, heterocycle‐tethered were employed in reaction first time. High enantioselectivity was achieved carbon‐tethered...
<sup>1</sup>H NMR metabolomics to study lipopolysaccharide-induced mice sepsis and the treatment effects of berberine.
Renal cell carcinoma (RCC) is the most common malignant disease of kidneys in adults. Patients with metastatic RCC have an unusually poor prognosis and exhibit resistance to all current therapies. Therefore, it necessary explore novel molecules involved progression identify effective therapeutic targets. Hepatocyte nuclear factor‑4α (HNF‑4α) serves important role hepatocyte differentiation liver cancer; however, functional HNF‑4α has not been well established RCC. The present study reported...