A5013675649- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurological and metabolic disorders
- Integrated Energy Systems Optimization
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Pluripotent Stem Cells Research
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Hybrid Renewable Energy Systems
- Peptidase Inhibition and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Energy and Environment Impacts
- Cardiac Structural Anomalies and Repair
- Cancer-related cognitive impairment studies
- Adrenal and Paraganglionic Tumors
- Nanocluster Synthesis and Applications
- Genomics and Rare Diseases
- Chemical Looping and Thermochemical Processes
- Advanced Nanomaterials in Catalysis
- Mitochondrial Function and Pathology
Huazhong University of Science and Technology
2018-2025
Tongji Hospital
2018-2025
Zhejiang University
2016-2024
State Key Laboratory of Clean Energy Utilization
2024
Jiaxing University
2024
Second Affiliated Hospital of Zhejiang University
2016-2021
Zhejiang Chinese Medical University
2016-2017
Ischemic stroke is a devastating disease and one of the leading causes mortality worldwide. Overproduction reactive oxygen nitrogen species (RONS) following ischemic insult known as key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production have great therapeutic potential. Herein, we propose an efficient treatment strategy which artificial nanozyme with multienzyme activity drives neuroprotection against primarily by scavenging RONS. Specifically,...
PET with <sup>18</sup>F-FDG has been used for presurgical localization of epileptogenic foci; however, in nonsurgical patients, the correlation between cerebral glucose metabolism and clinical severity not fully understood. The aim this study was to evaluate metabolic profile using PET/CT imaging patients epilepsy. <b>Methods:</b> One hundred pediatric epilepsy who underwent PET/CT, MRI, electroencephalography examinations were included. Fifteen age-matched controls also images analyzed by...
Since fibroblast activation protein (FAP), one predominant biomarker of cancer associated fibroblasts (CAFs), is highly expressed in the tumor stroma various epidermal-derived cancers, targeting FAP for diagnosis and treatment has shown substantial potentials both preclinical clinical studies. However, settings, tumor-bearing mice exhibit relatively low absolute expression levels, leading to challenges acquiring high-quality PET images using radiolabeled ligands (FAPIs) with molar activity,...
Posttraumatic stress disorder (PTSD) is an anxiety that occurs after exposure to a traumatic event. This study aimed investigate the neurobiologic changes before and exposure-based therapy by PET in rat model of PTSD. <b>Methods:</b> Serial <sup>18</sup>F-FDG imaging studies were performed under control (tone presentation), fear-conditioning, extinction retrieval phases. Neuroactivity marker c-Fos protein was used for immunostaining. <b>Results:</b> Increased glucose metabolism observed...
Major depressive disorder (MDD) is a common mental worldwide, but now there lack of clinically effective assessment and management MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99mTc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status MDD patients, explore an objective image model which non- or minimally-invasive, convenient accurate in clinical setting. The severity was assessed by three trained psychiatrists, based on scores obtained from HAMD...
The neuroprotective effect of ketosis state prior to the onset PD (preventive KD, KDp) was compared with that receiving KD after (therapeutic KDt) in lipopolysaccharide- (LPS-) induced rat model. A total 100 rats were randomly assigned following 4 groups: sham, LPS, LPS + KDp, and KDt groups. Significant dopamine deficient behaviors (rotational behavior contralateral forelimb akinesia), upregulation proinflammatory mediators (TNF-α, IL-1β, IL-6), loss dopaminergic neurons, reduction mGluR5+...
A landmark study from the Institute of Medicine reported that assessment cognitive difficulties in children with epilepsy is timely and imperative. Anticonvulsant-induced impairment could influence quality life more than seizure itself patients. Although monoaminergic system involved regulation process, its role anticonvulsant-induced remains unclear. <b>Methods:</b> To explore vivo monoamine receptor binding activity patients impairment, each patient underwent PET imaging both agent...
This study aimed to investigate in vivo dynamic metabolic changes after transplantation of induced pluripotent stem cells (iPSCs) and iPSC-derived enriched cardiomyocytes (iPSC-CMs) a rat model ischemic injury.Serial 18F-FDG PET, echocardiographic, immunohistochemical, immunofluorescence studies were performed iPSCs iPSC-CMs compared with embryonic (ESCs), ESC-CMs, phosphate-buffered saline control group rats myocardial infarction.Increased glucose metabolism periinfarct areas improved...
This study aimed to explore the glucose metabolic profile of extrapyramidal system in patients with crossed cerebellar diaschisis (CCD). Furthermore, connectivities cortico-ponto-cerebellar and cortico-rubral pathways associated CCD were also investigated. A total 130 positive (CCD+) 424 negative (CCD-) unilateral cerebral hemisphere hypometabolism on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) enrolled. Besides, control group consisted 56 subjects without any brain...
Crossed cerebellar diaschisis (CCD) has been widely investigated in patients with supratentorial hypometabolism, however, the available evidence about metabolic feature of CCD contralateral hypermetabolism is lacking. This study aimed to assess asymmetrical profile, network pattern and predisposing factors for hypermetabolism-associated CCD, by using voxel-based asymmetry index (AI) brain analyses. Seventy positive (CCD+) 99 negative (CCD-) unilateral were introduced. Among different regions...
Abstract The aim of this study was to explore the influences age‐matched control and/or age‐specific template on voxel‐wise analysis brain 18 F‐fluorodeoxyglucose positron emission tomography ( F‐FDG PET) data in pediatric epilepsy patients. We, retrospectively, included 538 (196 females; age range 12 months years) and 35 adult subjects (18 20–50 without any cerebral pathology as group, respectively, well 109 patients with drug‐resistant (38 13 group. Statistical parametric mapping (SPM) for...
The ability of PET/CT imaging to delineate neuroendocrine neoplasms (NENs) and predict prognosis in affected patients is often compromised by substantial uptake heterogeneity. We hereby proposed a hybrid standardized value (SUV) thresholding algorithm extract volumetric parameters from somatostatin receptor (SSTR) investigate their prognostic performance with 68Ga-DOTATATE-avid stage IV NENs.