A5100345567- Diabetes Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Studies
- Anesthesia and Neurotoxicity Research
- Glioma Diagnosis and Treatment
- Tryptophan and brain disorders
- Medical Imaging Techniques and Applications
- Cardiac Arrest and Resuscitation
- S100 Proteins and Annexins
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Traumatic Brain Injury Research
- Clinical Nutrition and Gastroenterology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Telomeres, Telomerase, and Senescence
- Ergonomics and Musculoskeletal Disorders
- Plant Toxicity and Pharmacological Properties
- Natural Antidiabetic Agents Studies
- Diet and metabolism studies
- Dermatology and Skin Diseases
- Intracranial Aneurysms: Treatment and Complications
Tongji University
2024-2025
First Affiliated Hospital of Shantou University Medical College
2025
Shantou University
2022-2025
Air Force Medical University
2021-2024
Shantou University Medical College
2023
Lanzhou University
2022-2023
Lanzhou University Second Hospital
2022-2023
Columbia University Irving Medical Center
2022
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2022
Shanxi Medical University
2017-2022
Type 2 diabetes mellitus (T2DM) is an important risk factor for Alzheimer's disease (AD). Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been identified to be effective in T2DM treatment neuroprotection. In this study, we further explored the effects of a novel unimolecular GLP-1/GIP/Gcg triagonist on cognitive behavior cerebral pathology 7-month-old triple transgenic mouse model AD (3xTg-AD), investigated its possible electrophysiological...
Abstract Background Alzheimer’s disease (AD) is an intractable neurodegenerative disorder in the elderly population, currently lacking a cure. Trichostatin A (TSA), histone deacetylase inhibitor, showed some neuroprotective roles, but its pathology-improvement effects AD are still uncertain, and underlying mechanisms remain to be elucidated. The present study aims examine anti-AD of TSA, particularly investigating cellular molecular mechanisms. Methods Novel object recognition Morris water...
Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms PND are closely related to perineuronal nets (PNNs). PNNs, which complexes extracellular matrix primarily surrounding neurons the hippocampus, play critical role function. Connexin 43 (Cx43) contributes function by modulating components PNNs. This study was designed investigate specific regulatory Cx43 on PNNs its pivotal...
Glutamate is one of the major excitatory neurotransmitters CNS and essential for numerous key neuronal functions. However, excess glutamate causes massive death brain damage owing to excitotoxicity via receptors. Metabotropic receptor 5 (mGluR5) receptors represents a promising target studying neuroprotective agents potential application in neurodegenerative diseases. Pu-erh tea, fermented mainly produced Yunnan province, China, has beneficial effects, including accommodation CNS. In this...
Mild hypothermia and its key product, cold-inducible protein RBM3, possess robust neuroprotective effects against various neurotoxins. However, we previously showed that mild fails to attenuate the neurotoxicity from MPP+ , one of typical neurotoxins related increasing risk Parkinson disease (PD). To better understand role RBM3 in PD progression, another known PD-related neurotoxin, rotenone (ROT) was utilized this study. Using immunoblotting, cell viability assays TUNEL staining, revealed...
Necrotizing Enterocolitis (NEC) is associated with prematurity, enteral feedings, and dysbiosis. Accordingly, we hypothesized that along nutritional variability, metabolic dysfunction would be NEC onset. Methods: We queried a multicenter longitudinal database included 995 preterm infants (<32 weeks gestation) 73 cases of NEC. Dried blood spot samples were obtained on day life 1, 7, 28, 42. Metabolite data from each time point 72 amino acid (AA) acylcarnitine (AC) measures. Nutrition averaged...
Insulin-like growth factor 1 (IGF1) and cardiotrophin (CT1) are known to increase the strength of extraocular muscles in adult embryonic animals, but no information is available for early postnatal period, when strabismus treatment humans most urgent. Here authors sought determine whether these trophic factors strengthen juvenile maturing gain insight into mechanisms force increase.After two injections IGF1, CT1, or both with different dosages posthatch chickens, quantified five parameters...
Accurate and convenient serological markers for prognosis after traumatic brain injury (TBI) are still lacking. We aimed to explore the predictive value of serum calcium prognosing outcomes within 6 months TBI.In this multicenter retrospective study, 1255 719 patients were included in development validation cohorts, respectively, their 6-month prognoses recorded. Serum was measured through routine blood tests 24 h hospital admission. Two multivariate models with or without developed....
The protective effect of rossicaside B, the major phenylpropanoid glycoside from Boschniakia rossica, on CCl(4)-induced hepatotoxicity and mechanisms underlying its were investigated. mice administered orally with B (100 or 200 mg/kg body weight) 48, 24 1 hr before CCl(4) (0.5 ml/kg administration. challenge caused a marked increase in levels serum aspartate aminotransferase, alanine aminotransferase tumour necrosis factor-alpha, propagated lipid peroxidation concomitant reduction reduced...
For children diagnosed with acute lymphoblastic leukemia (ALL), methotrexate (MTX) treatment carries the risk of leukoencephalopathy and other treatment-related brain damage. However, earlier more sensitive evaluation is needed to elucidate specific effects MTX in this group. This study aimed evaluate changes metabolites, diffusion anisotropy features, cognitive performance ALL after treatment.In observational conducted from December 2013 2015, 30 healthy were recruited evaluated using...
It remains unclear as to whether patients with brainstem tumor experience complex neuropsychiatric problems. In this cohort study, we specifically investigated behavioral, emotional and cognitive symptoms in pediatric glioma healthy individuals.A total of 146 tumors (aged 4-18 years old) 46 age-matched children were recruited assess their behaviors emotions examined by the Child Behavior Checklist. A variety clinical factors also analyzed.There significant differences most behavioral between...
Aim Hypertension is among the most prevalent chronic diseases with diverse etiology, affecting over 1 billion people globally. In numerous studies, vitamin C inversely correlated blood pressure and was suspected to have antihypertensive properties. Currently, there conflicting evidence regarding relationship between pressure, studies being conducted on hypertensive subjects. The principal objective of this project investigate in normotensive adult Methods A total 2,533 individuals aged 20...
<title>Abstract</title> Background Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms PND are closely related to perineuronal nets (PNNs). PNNs, which complexes extracellular matrix primarily surrounding neurons the hippocampus, play critical role function. Connexin 43 (Cx43) contributes function by modulating components PNNs. This study was designed investigate specific...
To observe the expressions of synaptophysin and BDNF/Trk-B in cerebellum APPswe/PS1dE9 transgenic mice.The healthy 9-month old APP/PS1 male mice (n1) same wild type mice(n2) were divided into two groups, group wild-type(WT) group. The brain-derived neurotrophic factor/tyrosine kinase B (BDNF/Trk-B) determined by Western blot (n1=6; n2=6) immunohistochemical(n1=4; n2=4).The possible synaptic changes observed using electron microscopy.Compared with WT group, synaptophsin decreased Increased...