A5100375461- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Phytochemical Studies and Bioactivities
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Natural product bioactivities and synthesis
- Vagus Nerve Stimulation Research
- Face Recognition and Perception
- Receptor Mechanisms and Signaling
- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Anesthesia and Neurotoxicity Research
- Antioxidant Activity and Oxidative Stress
- Medicinal Plants and Neuroprotection
- Phytochemistry and Bioactive Compounds
- Hippo pathway signaling and YAP/TAZ
- Regulation of Appetite and Obesity
- Cancer Treatment and Pharmacology
Air Force Medical University
2019-2024
Xijing Hospital
2019-2024
Dalian Medical University
2024
First Affiliated Hospital of Dalian Medical University
2024
Shandong University of Traditional Chinese Medicine
2024
Affiliated Hospital of Nantong University
2023
Shanghai University
2023
Nantong University
2023
Bengbu Medical College
2023
South China Normal University
2022
P-coumaric acid is an important phenolic compound that mainly found in fruits, vegetables, grains, and fungi also abundant Chinese herbal medicines. In this review, the pharmacological research progress of p-coumaric recent years was reviewed, with emphasis on its role mechanism oxidative stress-related diseases, such as inflammation, cardiovascular diabetes, nervous system diseases. Studies have shown has a positive effect prevention treatment these diseases by inhibiting stress. addition,...
Neuroinflammation and oxidative stress are major mechanisms of post-stroke cognitive impairment (PSCI) neural injury decreased spatial memory capacity. Enriched environment (EE) is an effective method to improve dysfunction. However, the regulation by EE neuroinflammation, associated in animal models remains unclear.In this study, a rat PSCI model was established middle cerebral artery occlusion (MCAO). Rats were randomly divided into control group, standard (SE) group for 28 days. A Morris...
Social stress, a common stressor, causes multiple forms of physical and mental dysfunction. Prolonged exposure to social stress is associated with higher risk psychological disorders, including anxiety disorders major depressive disorder (MDD). The orexinergic system involved in the regulation motivated behaviors. current study examined regulatory effect projections from lateral hypothalamic area (LHA) habenula (LHb) depression- anxiety-like behaviors after chronic defeat stress. When mice...
Myocardial ischemia/reperfusion injury (I/RI) may potentiate cardiac remodeling and heart failure, while effective therapies for I/RI remain lacking. Circulating human plasma-derived extracellular vesicles (hEV) have great potential to protect against I/RI. However, the delivery of hEV in vivo remains a limiting factor clinical application. The present study constructs biomimetic system platelet membrane-fused (P-hEV), utilizing natural affinity platelets injured vascular myocardial sites....
The ventral tegmental area (VTA) reportedly regulates sleep and wakefulness through communication with the lateral hypothalamus (LH). It has also been suggested that adequate anesthesia produced by administration of chloral hydrate, ketamine, or halothane significantly reduces GABAergic neuronal firing rate within VTA. However, exact effects on neurons in VTA mechanisms which these modulate associated neural circuits is still unclear. Here, we used optogenetic chemogenetic methods to...
BackgroundDespite the fundamental clinical significance of general anaesthesia, cortical mechanism underlying anaesthetic-induced loss consciousness (aLOC) remains elusive.MethodsHere, we measured dynamics two major neurotransmitters, gamma-aminobutyric acid (GABA) and glutamate, through in vivo two-photon imaging genetically encoded neurotransmitter sensors a cell type-specific manner primary visual (V1) cortex.FindingsWe found decrease GABA transmission during aLOC. However, glutamate...
Abstract Aims The circuitry mechanism associated with anesthesia‐induced unconsciousness is still largely unknown. It has been reported that orexinergic neurons of the lateral hypothalamus (LHA) facilitate emergence from anesthesia through their neuronal projections to arousal‐promoting brain areas. However, habenula (LHb), as one orexin downstream targets, known for its anesthesia‐promoting effect. Therefore, current study aimed explore whether and how LHA LHb have a regulatory effect on...
BackgroundSepsis-associated encephalopathy is characterised by cognitive dysfunction, and might be mediated deficits in neurotransmission. Reduced cholinergic neurotransmission the hippocampus impairs memory function. We assessed real-time alterations of acetylcholine from medial septal nucleus to hippocampus, explored whether sepsis-induced can relieved activating upstream projections.MethodLipopolysaccharide (LPS) injection or caecal ligation puncture (CLP) was used induce sepsis...
Abstract The lateral hypothalamic area (LHA) plays a pivotal role in regulating consciousness transition, which orexinergic neurons, GABAergic and melanin-concentrating hormone neurons are involved. Glutamatergic have large population the LHA, but their anesthesia-related effect has not been explored. Here, we found that genetic ablation of LHA glutamatergic shortened induction time prolonged recovery isoflurane anesthesia mice. In contrast, chemogenetic activation increased to decreased...
The key circadian genes, Period1(Per1), Period2(Per2), and Period3(Per3), constitute the mammalian Period gene family. abnormal expression of Per1 Per2 is closely related to tumor development, but there are few reports on Per3 tumorigenesis. This study was conducted determine whether could influence progression astroblastoma. results indicated that level increased in astroblastoma cells, high correlated with poor overall survival time glioma patients. role cells then investigated using two...
Abstract Stress during pregnancy may cause neurodevelopmental and psychiatric disorders. However, the mechanisms are largely unknown. Currently, pro‐inflammatory cytokines have been identified as a risk factor for depression anxiety disorder. Unfortunately, there is very little research on long‐term effects of prenatal stress neuroinflammatory system offspring. Moreover, relationship between antidepressant treatment in central nervous system, especially hippocampus, an important emotion...
BACKGROUND: Orexin, a neuropeptide derived from the perifornical area of hypothalamus (PeFLH), promotes recovery propofol, isoflurane, and sevoflurane anesthesias, without influencing induction time. However, whether orexinergic system also plays similar role in desflurane anesthesia, which is widely applied clinical practice owing to its most rapid onset offset time among all volatile anesthetics, has not yet been studied. In present study, we explored effect on consciousness state induced...
Total steroid saponins isolated from <i>Dioscorea zingiberensis</i> are a unique traditional Chinese medicine known for its potential usage in various types of diseases. However, there is little evidence about neuroprotective effect transient focal ischemia-reperfusion cerebral injury. Therefore, the current study was carried out to investigate total on neuroprotection and mechanisms rat model by middle artery occlusion 90 min. The rats were each treated with (30 mg/kg, 10 3 mg/kg) or...
Abstract We previously reported that conventional protein kinase C (c PKC )β participated in hypoxic preconditioning‐induced neuroprotection against cerebral ischemic injury, and collapsin response‐mediated 2 ( CRMP 2) was identified as a c β interacting protein. In this study, we explored the regulation of phosphorylation proteolysis by β, their role injury oxygen–glucose deprivation OGD )‐treated cortical neurons brains mice with middle artery occlusion‐induced stroke. The results...
Total steroid saponins isolated from Dioscorea zingiberensis have shown a variety of beneficial bioactivities. However, there are no reports about their neuroprotective effects, until now. Therefore, in the present study, we explored effects total D. on rats against transient focal cerebral ischemia-reperfusion and underlying mechanisms. Healthy adult Sprague-Dawley were randomly assigned to six groups. After pretreatment with intragastrically for days, subjected an ischemia injury by...
Introduction Multiple myeloma (MM) is a leading cause of hematopoietic cancer-related mortality, accounting for 20% deaths. MM-targeted therapies have demonstrated efficacy, and since 2015, the United States Food Drug Administration (FDA) has approved five targeted drugs. However, their cardiovascular safety not been comprehensively evaluated. Objective This study aimed to investigate association between therapy adverse events (AEs). Methods Disproportionality analysis was conducted on...
Canonical correlation analysis (CCA), a multivariate approach to identifying correlations between two sets of variables, is becoming increasingly popular in neuroimaging studies on brain-behavior relationships. However, the CCA stability applications has not been systematically investigated. Although it known that number subjects should be greater than variables due curse dimensionality, unclear at what subject-to-variable ratios (SVR) and strengths can maintained. Here, we assessed...