A5100658835- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cultural Heritage Materials Analysis
- RNA modifications and cancer
- Healthcare and Venom Research
- Circular RNAs in diseases
- Herpesvirus Infections and Treatments
- Renal cell carcinoma treatment
- Neuroscience of respiration and sleep
- Medical Research and Treatments
- Colorectal Cancer Treatments and Studies
- Acupuncture Treatment Research Studies
- Sleep and Wakefulness Research
- Building materials and conservation
- Antioxidant Activity and Oxidative Stress
- Conservation Techniques and Studies
- Pain Mechanisms and Treatments
- Dye analysis and toxicity
- Obstructive Sleep Apnea Research
- Pigment Synthesis and Properties
- Neonatal Respiratory Health Research
- Neuroscience and Neuropharmacology Research
- Gastric Cancer Management and Outcomes
- Retinal Imaging and Analysis
- Tea Polyphenols and Effects
Beijing Technology and Business University
2025
First Affiliated Hospital of Zhengzhou University
2023-2024
Zhengzhou University
2019-2024
Henan Provincial People's Hospital
2019-2024
Central South University
2013-2024
Fourth Hospital of Changsha
2020-2024
Southwest University
2024
Beijing Friendship Hospital
2024
Second Xiangya Hospital of Central South University
2013-2024
Cardiff University
2024
Epigallocatechin gallate (EGCG) has established protective actions against myocardial ischemia/reperfusion (I/R) injury by regulating autophagy. However, little is known about the mechanisms of EGCG in posttranscriptional regulation process cardioprotection. Here we studied whether microRNAs play a role EGCG-induced The I/R vitro and vivo model were made, with or without pretreatment. upregulation silencing microRNA-384-5p (miR-384) Beclin-1 H9c2 cell lines established. Rats transfected...
The dithia[3.3]paracyclophane-bridged bimetallic ruthenium alkynyl and vinyl complexes {Cp*(dppe)RuC≡C}2(μ-dithia[3.3]paracyclophane) (8) {(PMe3)3(CO)ClRuCH═CH}2(μ-dithia[3.3]paracyclophane) (9) have been prepared and, in the case of 8, structurally characterized. Compounds 8 9 each undergo two consecutive one-electron-oxidation processes, with supporting investigations conducted using IR UV/vis/near-IR spectroelectrochemical methods establishing redox-noninnocent character...
Several studies have reported that the long noncoding ribonucleic acid (lncRNA) NR2F1 antisense RNA 1 (NR2F1-AS1) affects multiple cellular pathways are involved in tumorigenesis and tumor progression. The present study aimed to detect NR2F1-AS1 expression non-small cell lung cancer (NSCLC), investigate role of promoting tumorigenic behavior NSCLC cells, elucidate mechanism underlying effect on Our results showed was upregulated notably, its upregulation correlated with adverse clinical...
Several novel immune checkpoint inhibitor (ICI)-based treatments exhibited promising survival benefits for metastatic renal cell carcinoma (mRCC), yet there is no current guidance regarding the optimum first-line regimen. We performed this network analysis to compare efficacy and safety of all available mRCC.
Till now, no study has focused on the functions of RNASEH1 antisense RNA 1 (RNASEH1-AS1) in non-small cell lung cancer (NSCLC). Accordingly, we measured expression RNASEH1-AS1 NSCLC and characterized its detail. Finally, our research elucidated mechanisms that occurred downstream RNASEH1-AS1.RNASEH1-AS1 was examined utilizing TCGA database qRT-PCR. Functional experiments were conducted to tumor-associated RNASEH1-AS1. The targeting relationship among RNASEH1-AS1, microRNA-516a-5p...
Abstract Tennis elbow (lateral epicondylitis) typically responds well to conservative treatment, and few patients require surgical intervention. This study aimed investigate the influence of lifestyle clinical factors on prognosis tennis elbow. prospective, multicenter, nested case–control included diagnosed with lateral epicondylitis after excluding other conditions. Patients who required surgery because inadequate improvement 6 months treatment were defined as case group; remaining...
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD) utilizing prospective cohort Mendelian randomization. The dataset contained a substantial of 426,911 participants from UK Biobank, discussing IBS PD with Cox proportional hazards models case-control analysis while adjusting for covariates such as age, gender, ethnicity education level. In univariate regression model, risk was reduced in patients (HR: 0.774, 95%CI: 0.625-0.956,...
The objective of the present study was to observe therapeutic effect paroxetine combined with fluorouracil on mice colorectal cancer (CRC) complicated depression and explore its mechanism action. Using chronic mild stress xenograft tumor methods model CRC depression, 60 BALB/c were randomly divided into control, model, antidepressant, chemotherapy antidepressant plus chemotherapeutic drug groups. Changes in mouse sucrose preference forced swimming tests tracked. volume weight compared,...
Abstract Guangzhou Tongcao paintings in Qing Dynasty of China witnessed the exchange economy, culture, art and technology between foreign countries, which were an important export product historical China. In this paper, by using Optical Stereo Microscope, Polarized Light Scanning Electron Microscope attached Energy Dispersive Spectroscopy micro confocal laser Raman Spectroscope, a painting with subject family life official’s female relative was analyzed. Our study revealed that: (1)...
Adiponectin (ADPN) plays an important role in cerebral ischemia-reperfusion injury. Although previous studies have confirmed that ADPN pretreatment has a protective effect on ischemic stroke, the therapeutic of stroke and underlying mechanism are still unclear. In order to clarify these questions, focal transient ischemia was induced by middle artery occlusion (MCAO) mice administered for three times at 6 h, 24 48 h after reperfusion. Meanwhile, virus-delivered HIF-1α siRNA used before...
ABSTRACTA high performance liquid chromatography method using an efficient extraction was developed for the determination of astaxanthin in eight kinds animal feed. The chromatographic separation achieved a C18 reversed-phase column, methanol and acetonitrile as mobile phases with flow rate 1 mL/min. feeds containing were first treated maxatase, to cause enzymatic hydrolysis, then extracted dichloromethane. optimized produced recoveries between 82.4% 100% all feed, coefficients variation...
Abstract This study set out to determine the key metabolite changes underlying pathophysiology of severe preeclampsia (PE) using metabolic analysis. We collected sera from 10 patients with PE and healthy pregnant women same trimester analyzed them liquid chromatography mass spectrometry. A total 3,138 differential metabolites were screened, resulting in identification 124 metabolites. Kyoto encyclopedia genes genomes pathway analysis revealed that they mainly enriched following pathways:...
Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder. Research conducted on patients with OSA using electroencephalography (EEG) has revealed noticeable shift in the overnight polysomnography (PSG) power spectrum. To better quantify effects of brain function and to identify most reliable predictors pathological cortical activation, this study quantified PSG its association degree hypoxia patients.This retrospective recruited 93 OSA. were divided into three groups...
Phase-amplitude coupling (PAC) between the phase of low-frequency signals and amplitude high-frequency activities plays many physiological roles is involved in pathological processed various neurological disorders. However, how neural oscillations or information synchronization change under chronic central hypoxia OSA patients whether these changes are closely associated with remains largely unexplored. This study arm to elucidate long-term consequences OSA-related oxygen deprivation on...
This study aimed to evaluate the efficacy of percutaneous coronary intervention (PCI) for significant atherosclerosis lesions proximal myocardial bridge (MB) at left anterior descending artery (LAD).A total 330 consecutive patients with LAD stenosis, diagnosed as acute syndrome (ACS), were included. Based on whether combined MB, divided into MB group (MB, n = 48) and non-MB (NMB, 282). Drug eluting stents (DES) successfully implanted in stenostic segments prior MB. All followed up during...
Bone microdamage can be repaired through bone remodeling induced by loading. In this study, a loading device was developed for improved efficiency and the self-repair process of studied in ovariectomized rats. First, four-point bending fixtures capable holding two live rats simultaneously were designed. Rats loaded subjected to sinusoidal wave 10,000 cycles. They then divided into four groups evaluate time points from 1 4 weeks repair process. The right ulna used parameter analysis, radius...