A5026666384- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Adipose Tissue and Metabolism
- Attention Deficit Hyperactivity Disorder
- Mechanisms of cancer metastasis
- Aldose Reductase and Taurine
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Sirtuins and Resveratrol in Medicine
- Maternal Mental Health During Pregnancy and Postpartum
- Neuroendocrine regulation and behavior
- Genetic Syndromes and Imprinting
- Psychosomatic Disorders and Their Treatments
- Muscle Physiology and Disorders
- Barrier Structure and Function Studies
- RNA modifications and cancer
- Fibroblast Growth Factor Research
- Rough Sets and Fuzzy Logic
- Chronic Myeloid Leukemia Treatments
- Glycogen Storage Diseases and Myoclonus
- Alzheimer's disease research and treatments
First Affiliated Hospital of Xi'an Jiaotong University
2019-2025
Chongqing University of Technology
2007-2024
Northwest University
2020
Xi'an Jiaotong University
2020
Baotou Medical College
2011
King's College London
2010
Rationale: Exogenous supplementation of beneficial intestinal bacteria can alleviate the behavioural symptoms psychiatric disorders, such as autism spectrum disorder (ASD), through gut-brain interactions. However, application bacteria, Lactobacillus reuteri (L. reuteri), for treating ASD is hindered by limited gut colonization. Methods: Utilizing Spirulina platensis (SP) a natural microcarrier safer and more binding approach was employed to bind surface SP produce SP-intestinal bacteria. Due...
Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder with a genetic origin. The purpose of present study was to analyze mutation spectrum CH patients in China. A targeted next‑generation sequencing panel covering all exons 29 CH‑related causative genes used 43 Han Chinese [11 dysgenesis and 32 glands situ (GIS)]. functional impact pathogenicity detected variants were analyzed using comprehensive bioinformatics approach co‑segregation studies. total 47 rare...
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders that affects children and even continues into adulthood. Dexmedetomidine (DEX), a short-term sedative, can selectively activate α2-adrenoceptor. Treatment with α2-adrenergic agonists in patients ADHD becoming increasingly common. However, therapeutic potential DEX for treatment unknown. Here, we evaluated effect on ADHD-like behavior spontaneously hypertensive rats (SHRs), widely used animal...
Abnormal amino acid metabolism in neural cells is involved the occurrence and development of major depressive disorder. Taurine an important required for brain development. Here, microdialysis combined with metabonomic analysis revealed that level taurine extracellular fluid cerebral medial prefrontal cortex (mPFC) was significantly reduced mice chronic social defeat stress (CSDS)-induced depression. Therefore, supplementation may be usable intervention We found effectively rescued...
Abstract Little is known about the effects of transcutaneous electrical acupoint stimulation (TEAS) for children with attention-deficit/hyperactivity disorder (ADHD). Here, we carried out a 4 week randomized clinical trial in which patients aged 6–12 years old an ADHD diagnosis received TEAS or sham TEAS. The primary outcome measure was investigator-rated Clinical Global Impression-Improvement (CGI-I) score at 4. Secondary outcomes included changes from baseline to Impression-Severity...
Brain edema is a grave complication of brain ischemia and the main cause herniation death. Although astrocytic swelling contributor to cytotoxic edema, molecular mechanism involved in this process remains elusive. N-myc downstream-regulated gene 2 (NDRG2), well-studied tumor suppressor gene, mainly expressed astrocytes mammalian brains. Here, we found that NDRG2 deficiency leads worsened cerebral imbalanced Na+ transfer, astrocyte after ischemia. We also deletion dramatically changed...
Social isolation during the juvenile stage results in structural and functional impairment of brain deviant adult aggression. However, specific subregions cell types that underpin this behavior are still largely unknown. Here, we found adolescent social led to a shortened latency attack onset extended average time, accompanied by anxiety-like deficits preference mice. when exposed adulthood, mice did not show these phenotypes. We also plasticity prefrontal pyramidal neurons, including...
Abstract Cerebral glycogen is principally localized in astrocytes rather than neurons. Glycogen metabolism has been implicated higher brain functions, including learning and memory, yet the distribution patterns of different types have not fully described. Here, we applied a method based on incorporation 2-NBDG, d -glucose fluorescent derivative that can trace glycogen, to investigate glycogen’s brain. We identified two astrocytes, namely, 2-NBDG I (glycogen-deficient) II (glycogen-rich)...
Alzheimer's disease (AD) is a chronic degenerative of the central nervous system and most common dementia type in elderly people. N-myc downstream-regulated gene 2 (NDRG2), cell stress response gene, primarily expressed astrocytes mammalian brains. The hippocampal protein levels NDRG2 AD patients were significantly higher than those healthy peers. However, whether increase involved development or an endogenous protective initiated by remains unknown. Here, we investigated roles memory...
Abstract General anesthesia severely affects the metabolites in brain. Glycogen, principally stored astrocytes and providing short-term delivery of substrates to neurons, has been implicated as an affected molecule. However, whether glycogen plays a pivotal role modulating anesthesia–arousal remains unclear. Here, we demonstrated that isoflurane-anesthetized mice exhibited dynamic changes levels various brain regions. Glycogen synthase (GS) phosphorylase (GP), key enzymes metabolism, showed...
Power cables are widely used in urban transmission and distribution networks, but cable accessory faults increasing year by year. Infrared temperature measurement is a commonly cable-charged detection method, there blind spot. Acoustic pattern can well make up for the lack of infrared technology piece voltage system heat type defects. Based on analysis several methods, this paper puts forward acoustic-optical joint to complement advantages two different diagnose accurately quickly.
<title>Abstract</title> Opioids abuse in adolescence is becoming a pressing public health issue. Although evidence indicates that adolescent opioid exposure contributes to persistent changes brain development, its long-term consequences adulthood are still unclear. Here, we established mouse model of morphine and used the 5-choice serial reaction time task (5‐CSRTT) combined with behavioral tests evaluate cognitive behaviors. We found during led deficits multidimensional functions mice,...
Abstract BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous psychiatric that can be divided into inattentive (I-ADHD), hyperactive-impulsive (HI-ADHD), and combined (C-ADHD) subtypes. Different early life events environmental factors correlated with the gut microbiota community have been implicated in development of ADHD. However, whether different ADHD symptomatic presentations are associated distinct composition function still unknown. Therefore, we carried...
Abstract Abnormal amino acid metabolism in neural cells is involved the occurrence and development of major depressive disorder. Taurine an important required for brain development. Here, microdialysis combined with metabonomics analysis showed that level taurine extracellular fluid cerebral medial prefrontal cortex (mPFC) was significantly reduced mice chronic social defeat stress (CSDS)-induced depression. Therefore, supplementation may be intervention We found could effectively rescue...
Objective To explore whether the expression level of heparanase (HPA) and its coagulation proteins on leukemic blast membrane could determine hemostatic balance surface leukemia cells.Methods Forty patients were studied,and 20 with iron dificient anemia as control group.Expression tissue factor (TF),heparanase (HPA),tissue pathway inhibitor (TFPI),and urokinase plasminogen activator receptor (UPAR) surfaces analyzed by flowcytometry.Results The TF,UPAR,and HPA in AML,ALL,CML,CLL CRAL groups...
Ensemble learning methods like Bagging and Boosting that train a diversity of classifiers by manipulating the training set given to base algorithm then combine their predictions in classification. And trade-off between accuracy component is crucial factor determining its generalization error. Both approach bootstrap sampling or re-weighting existing set. Some improved such as Decorate does this adding artificial instances into Although they achieve suitable some extent, have not focused...