A5101138518- Neurotransmitter Receptor Influence on Behavior
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Retinal Diseases and Treatments
- Neuropeptides and Animal Physiology
- Glaucoma and retinal disorders
- Network Security and Intrusion Detection
- Epigenetics and DNA Methylation
- Anomaly Detection Techniques and Applications
- Video Surveillance and Tracking Methods
- Peroxisome Proliferator-Activated Receptors
- CAR-T cell therapy research
- Cannabis and Cannabinoid Research
- Melamine detection and toxicity
- Mercury impact and mitigation studies
- Fatty Acid Research and Health
- Ferroptosis and cancer prognosis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Evacuation and Crowd Dynamics
- Sulfur Compounds in Biology
- Reinforcement Learning in Robotics
- AI in Service Interactions
- Face recognition and analysis
Southern Medical University
2024-2025
Shanxi Eye Hospital
2022-2025
Northwest University
2024-2025
Xi'an Jiaotong University
2021-2024
State Grid Corporation of China (China)
2024
Nanyang Technological University
2024
Hebei University of Chinese Medicine
2024
Shanghai Changzheng Hospital
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Chinese University of Hong Kong
2011-2021
Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action. However, the role of associated with diabetes obesity is unclear.UCP2 protects induced by high-fat diet through inhibition reactive oxygen species (ROS) production, subsequent increase nitric oxide bioavailability.Endothelium-dependent relaxation (EDR) aortae mesenteric arteries response to acetylcholine was...
The nucleus accumbens (NAc) is the most promising target for drug use disorder treatment. Deep brain stimulation (DBS) of NAc effective However, mechanisms by which DBS produces its therapeutic effects remain enigmatic. Here, we define a behavioral cutoff criterion to distinguish depressive-like behaviors and non-depressive-like in mice after morphine withdrawal. We identified basolateral amygdala (BLA) D1 medium spiny neuron (MSN) pathway that controls Furthermore, paraventricular thalamus...
Recent evidence highlights the therapeutic potential of peroxisome proliferator-activated receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, role PPARδ regulating vascular function is incompletely characterized. We investigate whether activation improves endothelial diabetic and obese mice. knockout (KO) wild-type (WT) mice fed with high-fat diet db/db were used as mouse models, compared KO WT on normal db/m(+) Endothelium-dependent relaxation (EDR) was...
Prolonged withdrawal from opioids leads to negative emotions. Kappa opioid receptor (KOR) plays an important role in addiction and affective disorders. However, the underlying mechanism of KOR withdrawal-related depression is still lacking. We found that escitalopram treatment had a limited effect improving symptoms heroin-dependent patients. In mice, we demonstrated prolonged (4 weeks) but not acute (24 h) morphine induced depressive-like behaviors. The number c-Fos positive cells...
Abstract Melamine incident, linked to nephrotoxicity and kidney stone in infants previously exposed melamine-contaminated milk products, was unprecedentedly grave China 2008 as little known about the mechanistic process leading renal dysfunction affected children. This study investigates whether neonatal ingestion of melamine leads vascular adulthood; pregnant rats their offspring. A combination approaches employed includes functional studies rat arteries, blood flow measurement by magnetic...
Abstract Long‐term opioid abuse causes a variety of long‐lasting cognitive impairments such as attention, impulsivity and working memory. These undermine behavioural treatment for drug lead to poor retention outcomes. Modafinil is wake‐promoting that shows potential in improving attention memory humans animals. However, modafinil's effect on opioid‐induced remains unclear, the underlying mechanism poorly understood. This study showed repeated morphine administration significantly impairs...
The present study was performed to detect the prevalence of myopia among primary-school students in Xi'an, north-western China.The a school-based with aged from 6 13 years old. All individuals underwent ophthalmological examination and spherical equivalent (SE) refractive error were measured non-cycloplegic refraction. Myopia defined as SE ≤ -0.5 diopters (D), further divided into three stratified groups based on SE: low (≤ >-3.0 D), moderate -3.0 >-6.0 high -6.0 D). Relative risk factors,...
Introduction: Acori Tatarinowii Rhizoma (ATR) is a well-known traditional Chinese medicine that used for treating neuropathic diseases. However, there little information about the safety of ATR. Methods: The present study evaluated acute and subacute oral toxicity water extract ATR in Institute Cancer Research (ICR) mice. In trials, single administration at dose 5,000 mg/kg body weight led to no clinical signs or mortality, indicating lethal (LD50) exceeded mg/kg. A test was done using daily...
Background: Comorbid chronic neuropathic pain (NPP) and anxio-depressive disorders (ADD) have become a serious global public-health problem. The SLIT NTRK-like 1 (SLITRK1) protein is important for synaptic remodeling highly expressed in the amygdala, an brain region involved various emotional behaviors. We examined whether SLITRK1 amygdala participates NPP comorbid ADD. Methods: A mouse model was constructed by L5 spinal nerve ligation; changes ADD-like behaviors were measured behavioral...
Purpose Myopia, especially high myopia (HM), represents a widespread visual impairment with globally escalating prevalence. This study aimed to elucidate the genetic foundations associated early-onset HM (eoHM) while delineating landscape specific Shaanxi province, China. Methods A comprehensive analysis of whole-exome sequencing was conducted involving 26 familial trios displaying eoHM. An exacting filtration protocol identified potential candidate mutations within acknowledged...
Abstract Background This study aimed at investigating the relationship between weekend catch-up outdoor duration (WCOD) and prevalence of myopia among students in China. Methods cross-sectional recruited participants 107 schools (six cities, 30 districts) from China May to June 2021. Demographic characteristics (age, grade, sex, ethnicity, BMI, resident, parents’ myopia), optically habits (bad writing habits, working/studying time per day, continuous screen day) (weekday weekend) were...
Analysis of high‐dimensional time series data is increasing interest among different fields. This article studies from a dimension reduction perspective using factor modelling. Statistical inference conducted eigen‐analysis certain non‐negative definite matrix related to autocovariance matrices the series, which applicable fixed or dimension. When goes infinity, rate convergence and limiting distributions estimated factors are established. Using factors, final prediction error criterion...
Congenital cataract-microcornea syndrome (CCMC) is characterized by the association of congenital cataract and microcornea without any other systemic anomaly or dysmorphism. Although several causative genes have been reported in patients with CCMC, genetic etiology CCMC yet to be clearly understood.To unravel cause autosomal dominant family CCMC.All available members underwent a comprehensive ophthalmologic clinical examination hospital expert ophthalmologists carried out clinically...