A5001714016- Muscle Physiology and Disorders
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Advanced Text Analysis Techniques
- Web Data Mining and Analysis
- Time Series Analysis and Forecasting
- Sleep and Wakefulness Research
- Human-Automation Interaction and Safety
- Sirtuins and Resveratrol in Medicine
- Genetic Syndromes and Imprinting
- Software Engineering Research
- Genomics and Chromatin Dynamics
- Nuclear Structure and Function
- Digital Mental Health Interventions
- Sleep and Work-Related Fatigue
- Emotion and Mood Recognition
- Traffic and Road Safety
- Calpain Protease Function and Regulation
- Software Testing and Debugging Techniques
- Silk-based biomaterials and applications
- RNA modifications and cancer
- Advanced Software Engineering Methodologies
- Aerospace and Aviation Technology
- Epigenetics and DNA Methylation
Universität Ulm
2023-2024
Paderborn University
2021
King's College London
2007-2012
Guy's Hospital
2007
Alternative polyadenylation increases transcriptome diversity by generating multiple transcript isoforms from a single gene.It is thought that this process can be subject to epigenetic regulation, but few specific examples of have been reported.We previously showed the Mcts2/H13 locus genomic imprinting and alternative H13 transcripts occurs in an allele-specific manner, regulated mechanisms.Here, we demonstrate allelespecific at another imprinted with similar features.Nap1l5 retrogene...
Dystrophins and dystrobrevins are distantly related proteins with important but poorly understood roles in the function of metazoan muscular neuronal tissues. Defects them their associated cause a range neuromuscular disorders. Members this superfamily have been discovered relatively serendipitous way; we set out to compile comprehensive description dystrophin- dystrobrevin-related sequences from available genome sequences, validated representative organisms by RT-PCR, or acquired de novo...
Abstract Background The dystrophin glycoprotein complex is disrupted in Duchenne muscular dystrophy and many other neuromuscular diseases. principal heterodimeric partner of at the heart main clinically affected tissues (skeletal muscle, brain) its distant relative, α-dystrobrevin. α-dystrobrevin gene subject to transcriptional post-transcriptional regulation, generating a substantial range isoforms by alternative promoter use, polyadenylation splicing. choice isoform understood, amongst...
The advance of automated driving allows the users to engage in non-driving related activities such as sleeping. However, until full automation is reached, user may have interact with vehicle, for example, planned take-overs, which requires be awake and conscious. To evaluate auditory visual awakening concepts (alarm, fading 5, 20s), we conducted a between-subject (N=45) Virtual Reality study, participants dozed/slept 15min, were then awoken, had complete an ordering, stroop, counting task....
Developers of configurable software use the concept selecting and deselecting features to create different variants a product. In this context, one most challenging aspects is identify unwanted interactions between those features. Due combinatorial explosion number potentially interacting features, it currently an open question how systematically particular feature interaction that causes specific fault in set products. paper, we propose incremental approach such t-wise based on testing...
Interactive driving simulation has become a key technology to support the development and optimization process of modern vehicle components driver assistance systems both in academic research automotive industry. However, validity results obtained within virtual environment depends essentially on adequate reproduction simulated movements corresponding immersion driver. For that reason, specific motion platform control strategies, so-called Motion Cueing Algorithms (MCA), are used replicate...