A5103019556- Cancer-related gene regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Virus-based gene therapy research
- Garlic and Onion Studies
- Wnt/β-catenin signaling in development and cancer
- Eicosanoids and Hypertension Pharmacology
- HIV Research and Treatment
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Sulfur Compounds in Biology
- Ferroelectric and Negative Capacitance Devices
- Mitochondrial Function and Pathology
- Redox biology and oxidative stress
- Selenium in Biological Systems
- RNA Research and Splicing
- DNA Repair Mechanisms
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- RNA Interference and Gene Delivery
Northwestern Polytechnical University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2023
Xi'an Jiaotong University
2014-2023
First Affiliated Hospital of Xi'an Jiaotong University
2019-2022
Jilin University
2021
Indiana University School of Medicine
2014
China XD Group (China)
2014
Allicin, the main biologically active compound derived from garlic, exerts a broad spectrum of pharmacological activities and is considered to have therapeutic potential in many neurological disorders. Using an vitro spinal cord injury model induced by glutamate treatment, we sought investigate neuroprotective effects allicin primary cultured neurons. We found that treatment significantly attenuated glutamate-induced lactate dehydrogenase (LDH) release, loss cell viability apoptotic neuronal...
Laryngeal squamous cell carcinoma (LSCC) is an aggressive malignancy with highly mortality rate. Long non-coding RNA (lncRNA) AGAP2-AS1 identified oncogene in several types of cancers. However, the role LSCC remains unclear. The expression levels tissues and lines were measured using qRT-PCR. was knocked down cells through transfection siRNA-AGAP2-AS1. Cell proliferation invasion detected MTT transwell assays. Dual-luciferase reporter gene assay performed to confirm interaction downstream...
Up-regulation of family with sequence similarity 83 member D (FAM83D) has been acknowledged as a vital contributor for the carcinogenesis numerous cancers. The relevance FAM83D in glioblastoma (GBM), however, is not well understood. This current work aimed to determine possible roles and mechanisms GBM. By analyzing Cancer Genome Atlas (TCGA) data, we found dramatic increases expression GBM tissue. We also observed elevated levels clinical specimens In vitro data showed that silencing...
DNA2, a multifunctional enzyme with structure-specific nuclease, 5 '-to-3 ' helicase, and DNA-dependent ATPase activities, plays pivotal role in the cellular response to DNA damage. However, its involvement cerebral ischemia/reperfusion (I/R) injury remains be elucidated. This study investigated of DNA2 I/R using conditional knockout (cKO) mice ( Nestin-Cre) subjected middle artery occlusion (MCAO), an established model I/R. Results demonstrated gradual up-regulation expression, peaking at...
Ischemia stroke and epilepsy are two neurological diseases that have significant patient societal burden, with similar symptoms of deficits. However, the underlying mechanism their co-morbidity still unclear. In this study, we performed a combined analysis six gene expression profiles (GSE58294, GSE22255, GSE143272, GSE88723, GSE163654, GSE174574) to reveal common mechanisms IS epilepsy. mouse datasets, 74 genes were co-upregulated 7 co-downregulated in groups. Further revealed co-expressed...
Abstract Background Glioma was a malignant tumor of the central nervous system. m6A methylation and HIF-1α were related to occurrence development gliomas. However, co-mechanism in glioma is unclear. Objective This aim determine glioma. Methods Elisa dot blot used detect level. The changes genes, biological pathways gene ontology analyzed by bioinformatics. METTL3 knockdown sh-RNA, mRNA protein level detected qPCR western blot. In addition, RNA sites predicted verified m6A-RIP-MMP-6 analysis༎...