A5013518217- Genetic Associations and Epidemiology
- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Folate and B Vitamins Research
- Bone health and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Hepatitis B Virus Studies
- Growth Hormone and Insulin-like Growth Factors
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Genomic variations and chromosomal abnormalities
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
- RNA Research and Splicing
- Selenium in Biological Systems
Tulane University
2016-2025
Guangzhou Institutes of Biomedicine and Health
2021-2025
State Key Laboratory of Respiratory Disease
2024-2025
Chinese Academy of Sciences
2022-2025
Lanzhou University
2025
China Agricultural University
2025
Guangzhou Medical University
2021-2024
University of California, San Francisco
2011-2024
San Francisco VA Medical Center
2011-2024
San Francisco VA Health Care System
2024
Recent technology has made it possible to simultaneously perform multi-platform genomic profiling (e.g. DNA methylation (DM) and gene expression (GE)) of biological samples, resulting in so-called 'multi-dimensional data'. Such data provide unique opportunities study the coordination between regulatory mechanisms on multiple levels. However, integrative analysis multi-dimensional genomics for discovery combinatorial patterns is currently lacking. Here, we adopt a joint matrix factorization...
We evaluated the effect of weight loss on urinary incontinence (UI) in overweight and obese women.A randomized, controlled clinical trial was conducted among women experiencing at least 4 UI episodes per week. Women were randomly assigned to a 3-month liquid diet reduction program (24 immediate intervention group) or wait-list delayed group control group). Participants began month 3 study. All followed for 6 months after completing program. Wilcoxon tests used compare intergroup differences...
Cardiac rehabilitation is strongly recommended after myocardial infarction, percutaneous coronary intervention, or artery bypass surgery, but it historically underused. We sought to evaluate variation in cardiac participation across the United States.
Abstract Background Increasing evidence suggests that human gut microbiome plays an important role in variation of skeletal muscle mass (SMM). However, specific causal mechanistic relationship with SMM remains largely unresolved. Understanding the may provide a basis for novel interventions loss SMM. This study investigated whether has effect on among Chinese community‐dwelling healthy menopausal women. Methods Estimated was derived from whole‐body dual‐energy X‐ray absorptiometry. We...
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stromal that have a critical role in the maintenance of skeletal tissues such as bone, cartilage, and fat bone marrow.In addition to providing microenvironmental support for hematopoietic processes, BM-MSCs can differentiate into various mesodermal lineages including osteoblast/osteocyte, chondrocyte, adipocyte crucial metabolism.While high cell-to-cell heterogeneity gene expression, cell subtypes contribute this vivo...
Abstract Although the gut microbiota has been reported to influence osteoporosis risk, individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found be negatively associated mineral density (BMD), which validated US white people. Serum...
Bromodomain-selective BET inhibition has emerged as a promising strategy to improve the safety profiles of pan-BET inhibitors. Herein, we report discovery potent phenoxyaryl pyridones highly BD2-selective Compound 23 (IC50 = 2.9 nM) exhibited comparable BRD4 BD2 inhibitory activity relative 10 1.0 and remarkably improved selectivity over BD1 (23: 2583-fold; 10: 344-fold). This lead compound significantly inhibited proliferation acute myeloid leukemia (AML) cell lines through induction G0/G1...
The transcriptional coactivator cAMP response element binding protein (CREB)-binding (CBP) and its homologue p300 have emerged as attractive therapeutic targets for human cancers such acute myeloid leukemia (AML). Herein, we report the design, synthesis, biological evaluation of a series cereblon (CRBN)-recruiting CBP/p300 proteolysis targeting chimeras (PROTACs) based on inhibitor CCS1477. representative compounds
Many veterans may not be candidates for hepatitis C virus (HCV) treatment due to contraindications therapy. The aims of this study were determine the proportion HCV-infected who eligible interferon alfa and ribavirin therapy evaluate barriers HCV treatment.We prospectively enrolled 4,084 referred over a 1-yr period at 24 Veterans Affairs (VA) Medical Centers. Treatment candidacy was assessed using standardized criteria opinion treating clinician.Overall, 32.2% (95% CI, 30.8-33.7%) according...
Abstract Osteoporosis is an important health problem, particularly in the elderly women. Bone mineral density (BMD) a major determinant of osteoporosis. For sample 53 pedigrees that contain 1249 sibling pairs, 1098 grandparent-grandchildren and 2589 first cousin we performed whole- genome linkage scan using 380 microsatellite markers to identify genomic regions may quantitative trait loci (QTL) BMD. Each pedigree was ascertained through proband with BMD values belonging bottom 10%...
Bone mineral density (BMD) is a major risk factor for osteoporosis. Circulating monocytes may serve as early progenitors of osteoclasts and produce wide variety factors important to bone metabolism. However, little known about the roles circulating in relation pathophysiology Using Affymetrix HG-U133A GeneChip(R) array, we performed comparative gene expression study subjects with high low BMD. We identified total 66 differentially expressed genes including some novel well already be relevant...
Whole genome sequencing studies are essential to obtain a comprehensive understanding of the vast pattern human genomic variations. Here we report results high-coverage whole study for 44 unrelated healthy Caucasian adults, each sequenced over 50-fold coverage (averaging 65.8×). We identified approximately 11 million single nucleotide polymorphisms (SNPs), 2.8 short insertions and deletions, 500,000 block substitutions. showed that, although previous studies, including 1000 Genomes Project...