A5076921558- Genetic Associations and Epidemiology
- Gut microbiota and health
- Diet and metabolism studies
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Lipoproteins and Cardiovascular Health
- Metabolism and Genetic Disorders
- Bone Metabolism and Diseases
- SARS-CoV-2 and COVID-19 Research
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Ginseng Biological Effects and Applications
- COVID-19 Clinical Research Studies
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Folate and B Vitamins Research
- Body Composition Measurement Techniques
- Reproductive System and Pregnancy
- Diabetes Treatment and Management
- Gastrointestinal motility and disorders
- Digestive system and related health
Hangzhou Medical College
2022-2024
Central South University
2019-2023
Zhejiang Academy of Medical Sciences
2022
Zhengzhou University
2017-2018
Abstract Background Increasing evidence suggests that human gut microbiome plays an important role in variation of skeletal muscle mass (SMM). However, specific causal mechanistic relationship with SMM remains largely unresolved. Understanding the may provide a basis for novel interventions loss SMM. This study investigated whether has effect on among Chinese community‐dwelling healthy menopausal women. Methods Estimated was derived from whole‐body dual‐energy X‐ray absorptiometry. We...
Abstract Although the gut microbiota has been reported to influence osteoporosis risk, individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found be negatively associated mineral density (BMD), which validated US white people. Serum...
The homeostasis of bone metabolism depends on the coupling and precise regulation various types cells in tissue. However, communication interaction between tissue at single-cell level remains poorly understood. Thus, we performed RNA sequencing (scRNA-seq) primary human femoral head (FHTCs). Nine cell were identified 26,574 FHTCs, including granulocytes, T cells, monocytes, B red blood osteoblastic lineage endothelial progenitor (EPCs) plasmacytoid dendritic cells. We
Both sarcopenia and osteoporosis are common geriatric diseases causing huge socioeconomic burdens, clinically, they often occur simultaneously. Observational studies have found a controversial correlation between their causal relationship is not clear. Therefore, we performed bi-directional two-sample Mendelian randomization (MR) analysis to assess the potential sarcopenia-related traits (hand grip strength, lean mass, walking pace) osteoporosis. Our was by applying genetic variants obtained...
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had given rise to a massive epidemic. Owing the high morbidity and mortality of COVID-19 lack effective therapies, safe vaccination is optimum choice for controlling this epidemic preventing infection. The protein subunit vaccine ZF2001, which targets receptor-binding domain (RBD) SARS-CoV-2, has significant protective effect against COVID-19. At beginning epidemic, promote early...
Observational studies have demonstrated that cardiovascular risk factors are associated with chronic kidney disease (CKD). However, these observational associations potentially influenced by the residual confounding, including some unmeasured lifestyle and interaction factors. Two-sample mendelian randomization analysis was conducted in this study to evaluate whether genetically predicted a causal effect on of CKD. We selected genetic variants extracted corresponding sizes from largest GWAS...
Previous Mendelian randomization (MR) studies have yielded a conflicting causal relationship between sarcopenia and coronary artery disease (CAD), lack the association of CAD with sarcopenia.We performed bi-directional MR approach to clarify causality direction sarcopeniarelated traits CAD.In stage 1 analysis, estimates inverse variance weighting (IVW) several sensitivity analyses were obtained by applying genetic variants that predict sarcopenia-related CAD.Conversely, we also applied in 2...
Functional constipation (FC) is a high morbidity gastrointestinal disease for which dysfunction in the enteric nervous system major pathogenesis mechanism. To enhance our understanding of involvement intestinal microbiota and its metabolites FC, we conducted shotgun metagenomic sequencing analysis gut serum short-chain fatty acids (SCFAs) 460 Chinese women with different defecation frequencies. We observed that abundance Fusobacterium_varium , butyric acid-producing bacterium, was positively...
Genome-wide association studies (GWASs) have been performed extensively in diverse populations to identify single nucleotide polymorphisms (SNPs) associated with complex diseases or traits. However, date, the SNPs identified fail explain a large proportion of variance traits/diseases. GWASs on type 2 diabetes (T2D) and obesity are generally focused individual traits independently, genetic intercommunity (common contributions product over correlated phenotypic world) between them largely...
Obesity-related traits have been associated with coronary artery disease (CAD) in observational studies, but these associations may be biased by confounding factors and reverse causation. In this study, we specifically conducted two-sample Mendelian randomization (MR) analyses to overcome limitations test the of obesity-related (other than body mass index (BMI)) (n = 322,154) CAD (22,233 cases 64,762 controls) using summary-level data from previous studies. The methods utilized estimate...
ZF2001, a protein subunit vaccine against coronavirus disease 2019 (COVID-19), contains recombinant tandem repeat of dimeric receptor-binding domain (RBD) the SARS-CoV-2 spike with an aluminium-based adjuvant. During development this vaccine, two nonclinical studies were conducted to evaluate female fertility, embryo-fetal development, and postnatal developmental toxicity in Sprague‒Dawley rats according ICH S5 (R3) guideline. In Study 1 (embryo-fetal toxicity, EFD), 144 virgin randomly...
Although the new coronavirus disease 2019 (COVID-19) outbreak occurred in late 2019, it is still endemic worldwide, and has become a global public health problem. Vaccination against SARS-CoV-2 considered to be most effective intervention prevent spread of COVID-19. ZF2001 recombinant protein vaccine based on receptor-binding domain (RBD) subunit which contains aluminum adjuvant. In order advance our research into clinical trial, we investigated general toxicity immunogenicity cynomolgus...
Cow milk consumption (CMC) and alterations of gut bacterial composition are proposed to be closely related human health disease. Our research aims investigate the changes in microbial Chinese peri-/postmenopausal women with different CMC habits. A total 517 subjects were recruited questionnaires about their status collected; 394 included final analyses. Fecal samples used for studying composition. All divided into a control group (n = 248) 146) according status. Non-parametric tests LEfSe at...
The coronavirus disease 19 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2), which has rapidly increasing prevalence and significant morbidity/mortality. Despite the availability of many vaccines that can offer widespread immunization, it also important to reach effective treatment for COVID-19 patients. However, development novel drug therapeutics usually time-consuming costly process, therefore, repositioning drugs were previously approved other...
Abstract Although gut microbiota influences osteoporosis risk, the individual species involved, and underlying mechanisms, are unknown. We performed integrative analyses in a Chinese cohort with metagenomics/targeted metabolomics/whole-genome sequencing. Bacteroides vulgatus was found negatively associated bone mineral density (BMD), this association validated US Caucasians. Serum valeric acid positively BMD, B.vulgatus causally downregulated it. Ovariectomized mice fed had decreased...