Lei Wen

ORCID: 0000-0002-3461-6060
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Environmental Impact and Sustainability
  • Energy, Environment, Economic Growth
  • Hydrology and Watershed Management Studies
  • Flood Risk Assessment and Management
  • Air Quality and Health Impacts
  • Climate variability and models
  • Energy, Environment, and Transportation Policies
  • Meteorological Phenomena and Simulations
  • Vehicle emissions and performance
  • Climate Change Policy and Economics
  • Cryospheric studies and observations
  • Hydrology and Drought Analysis
  • Supply Chain Resilience and Risk Management
  • Evaluation Methods in Various Fields
  • Brain Metastases and Treatment
  • Sustainable Supply Chain Management
  • Plant Water Relations and Carbon Dynamics
  • Lung Cancer Research Studies
  • Grey System Theory Applications
  • Membrane-based Ion Separation Techniques
  • Membrane Separation Technologies
  • Lung Cancer Treatments and Mutations
  • Soil erosion and sediment transport
  • Chinese history and philosophy
  • Multiple Myeloma Research and Treatments

Peking University
2023-2025

Peking University People's Hospital
2023-2025

North China Electric Power University
2015-2024

Guangdong 999 Brain Hospital
2019-2024

Southern Medical University
2024

Hohai University
2013-2024

Xiangtan University
2023-2024

Yunnan University
2022-2024

Sun Yat-sen University Cancer Center
2024

Zhujiang Hospital
2024

Abstract The emergence of SARS-CoV-2 variants concern and repeated outbreaks coronavirus epidemics in the past two decades emphasize need for next-generation pan-coronaviral therapeutics. Drugging multi-functional papain-like protease (PLpro) domain viral nsp3 holds promise. However, none known PLpro inhibitors has been shown to be vivo active. Herein, we screened a structurally diverse library 50,080 compounds potential identified noncovalent lead inhibitor F0213 that broad-spectrum...

10.1007/s13238-022-00909-3 article EN cc-by Protein & Cell 2022-04-06

10.1007/s11356-022-19595-z article EN Environmental Science and Pollution Research 2022-03-22

Droughts are among the world's most costly natural disasters and collectively affect more people than any other form of disaster. The Canadian Prairies very susceptible to drought have experienced this phenomenon many times. However, recent 1999–2005 Prairie was one worst meteorological, agricultural hydrologic droughts over instrumental record. It also had major socio-economic consequences, adding up losses in billions dollars. This focus Drought Research Initiative (DRI), first integrated...

10.1080/07055900.2011.626757 article FR ATMOSPHERE-OCEAN 2011-10-24

ABSTRACT Background This study compares the efficacy and safety of single autologous stem cell transplantation (ASCT) versus tandem ASCT for multiple myeloma (MM) patients in era novel agents. Methods A total 112 high‐risk MM were included (single ASCT, (n = 57) or 55) this retrospective multicenter study. Responses outcomes evaluated. Results At 100 days after ASCT1 ASCT2, 36 (63.2%) 45 (81.8%) achieved sCR/CR, 16 (28.1%) 7 (12.7%) VGPR, 5 (8.8%) 1 (1.8%) patient PR, respectively, cohorts....

10.1002/cam4.70573 article EN cc-by Cancer Medicine 2025-01-01

Given the growing global focus on sustainable development, land management has emerged as a critical concern in contemporary agricultural development. The efficacy of production and its influencing factors Shaanxi province China, from 2012 to 2021, were analyzed using Data envelopment analysis (DEA)-Banker, Charnes, Cooper model. Input output indicators selected for analysis. Inputs consist land, machinery, water, fertilizer. Specific include total sown area crops, effective irrigated area,...

10.36922/eer.5129 article EN cc-by 2025-01-20

Background: Macrofocal multiple myeloma (MFMM) is characterized by clonal plasma cells comprising less than 20% of the bone marrow, lytic lesions, and absence anemia, renal insufficiency, hypercalcemia. This subtype (MM) has a relatively low incidence. Prognostic staging cytogenetic guidance for MFMM are often insufficient due to tumor burden in marrow. Large cohort studies on this subgroup during era novel agents limited. Objectives: We aim describe clinical characteristics prognostic...

10.1177/20406207251314696 article EN cc-by-nc Therapeutic Advances in Hematology 2025-01-01

Flood forecasting is crucial for disaster mitigation, particularly in regions prone to flash floods. This study introduces a novel flood framework by coupling the Geomorphological Instantaneous Unit Hydrograph (GIUH) with Xinanjiang model and optimizing parameters using Cooperation Search Algorithm (CSA). Applied across six diverse Chinese catchments, significantly improved computational efficiency accuracy. Key findings demonstrate that: 1) CSA achieved high Nash-Sutcliffe Efficiency (NSE...

10.3389/feart.2025.1538235 article EN cc-by Frontiers in Earth Science 2025-02-11

Abstract We use the Variable Infiltration Capacity (VIC) land surface macroscale hydrology model driven by observed maximum and minimum air temperatures precipitation to map daily soil moisture values over China for period 1 January 1971 31 July 2005. The is applied a grid of 10 458 points with resolution 30 km × km. first calibrated using hydrographs from 35 catchments drainage areas varying 190 351 530 km2. then validated these at different periods, an additional eight ranging 1230 010 An...

10.3137/ao.v450103 article FR other-oa ATMOSPHERE-OCEAN 2007-03-01

SUMMARY Bacillary dysentery continues to be a major health issue in developing countries and ambient temperature is possible environmental determinant. However, evidence about the risk of bacillary attributable under climate change scenarios scarce. We examined fraction (AF) temperature-related urban rural Hefei, China during 2006–2012 projected its shifting pattern using distributed lag non-linear model. The increased with rise above threshold (18·4 °C), effects appeared acute. proportion...

10.1017/s0950268817000280 article EN Epidemiology and Infection 2017-03-15
Coming Soon ...