A5100360811- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Advanced Clustering Algorithms Research
- Advanced Text Analysis Techniques
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Complex Network Analysis Techniques
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Advanced Fluorescence Microscopy Techniques
- Machine Learning in Bioinformatics
- Protein Degradation and Inhibitors
- Single-cell and spatial transcriptomics
University of Utah
2019-2025
Xi'an Jiaotong University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
UCLA Health
2022
Yangzhou University
2020
University of Southern California
2011-2012
The University of Texas at Dallas
2006-2008
Recent technology has made it possible to simultaneously perform multi-platform genomic profiling (e.g. DNA methylation (DM) and gene expression (GE)) of biological samples, resulting in so-called 'multi-dimensional data'. Such data provide unique opportunities study the coordination between regulatory mechanisms on multiple levels. However, integrative analysis multi-dimensional genomics for discovery combinatorial patterns is currently lacking. Here, we adopt a joint matrix factorization...
Zeteketoxin AB is the only macrocyclic member of bis-guanidinium ion toxins, and reported to be more potent than parent (+)-saxitoxin. A rationale for this exquisite potency remains difficult develop due scarcity natural material a lack consensus around specific structure toxin itself. strategy reported, leveraging an intramolecular Michael addition forge macrocycles bridging saxitoxin core, mimicking proposed zetekitoxin AB. Intriguingly, these analogs do not form hydrate at C12....
Alternative polyadenylation (APA) plays a crucial role in cancer development and prognosis. However, the molecular characteristics of APA related to non-small cell lung (NSCLC) susceptibility remain understudied, especially East Asian populations. In this study, we constructed an atlas APA-regulated 3' untranslated region (3'UTR) profiled its genetic regulation 747 tissue samples (including tumors paired normal tissues) from 417 NSCLC Chinese patients. We verified significant global...
Microarrays allow researchers to monitor the gene expression patterns for tens of thousands genes across a wide range cellular responses, phenotype and conditions. Selecting small subset discriminate from is important accurate classification diseases phenotypes. Many methods have been proposed find subsets with maximum relevance minimum redundancy, which can distinguish accurately between samples different labels. To relevant often referred as biomarker discovery. Two main approaches, filter...
Chemotherapy is widely used for cancer therapy but with unsatisfied efficacy, mainly due to the inefficient delivery of anticancer agents. Among critical "five steps" drug process, internalization into tumor cells and intracellular release are two important steps overall therapeutic efficiency. Strategy based on active targeting or TME-responsive developed individually improve efficiency, limited improvement. However, combination these strategies could potentially augment efficiency...
Abstract Background Alternative splicing is a ubiquitous gene regulatory mechanism that dramatically increases the complexity of proteome. However, for regulating alternative poorly understood, and study coordinated regulation has been limited to individual cases. To genome-wide regulation, we integrate many human RNA-seq datasets identify module, which define as set cassette exons co-regulated by same factors. Results We have designed tensor-based approach co-splicing clusters appear...
Single-molecule fluorescence imaging is a powerful method to measure reversible reaction kinetics, allowing one monitor the bound state of individual probe molecules with fluorescently labeled targets. In case DNA hybridization, previous studies have shown that presence fluorescent label on target strand can exhibit significant influence stability duplex formed. this work, we developed super-resolution hybridization kinetics unlabeled compete tracer hybridize an immobilized at surface. The...
DJ‑1, an oncogene, has been reported to be independent prognostic indicator of poor survival in patients with esophageal squamous cell carcinoma (ESCC). The aim the present study was investigate role DJ‑1 tumor proliferation and invasion ESCC its underlying mechanisms. It observed that expression level upregulated positively associated EMT biomarkers 84 human tissue specimens. Overexpression knockdown experiments demonstrated involved proliferation, migration, ECA‑109 cells vitro extensive...
How best to present query search results is an important problem in engines and information retrieval systems. When a single retrieves many results, simply showing them as long list will provide users with poor overview. Nowadays, ranking clustering have been two useful separate post-processing techniques organize retrieved documents. In this paper, we proposed spectral analysis method based on the content similarity networks integrate for improving literature search. The new approach...
Alternative splicing is a ubiquitous gene regulatory mechanism that dramatically increases the complexity of proteome. In this paper we study module, which define as set cassette exons co-regulated by same factors. We have designed tensor-based approach to identify co-splicing clusters appear frequently across multiple conditions, thus very likely represent modules - unit in network. particular, model each RNA-seq dataset network, where nodes and edges are weighted correlations between exon...