A5033269764- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Bone Metabolism and Diseases
- Selenium in Biological Systems
- Bioinformatics and Genomic Networks
- Sleep and related disorders
- Bipolar Disorder and Treatment
- Health disparities and outcomes
- Adolescent and Pediatric Healthcare
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Folate and B Vitamins Research
- Obesity, Physical Activity, Diet
- Autism Spectrum Disorder Research
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Eating Disorders and Behaviors
- Child and Adolescent Psychosocial and Emotional Development
- Gout, Hyperuricemia, Uric Acid
National Health and Family Planning Commission
2018-2025
Xi'an Jiaotong University
2018-2025
Jiangxi Normal University
2024
Ministry of Education of the People's Republic of China
2022
Northwest University
2016
Abstract Psychiatric disorders are a group of complex psychological syndromes with high prevalence. It has been reported that gut microbiota dominant influence on the risks psychiatric through microbiota–brain axis. We extended classic gene set enrichment analysis (GSEA) approach to detect association between and diseases using published genome-wide study (GWAS) GWAS summary data. applied our real data sets five disorders, including attention deficiency/hyperactive disorder (ADHD), autism...
Recent study demonstrates the comprehensive effects of gut microbiota on complex diseases or traits. However, limited effort has been conducted to explore potential relationships between and BMD.We performed a polygenetic risk scoring (PRS) analysis systematically body BMD. Significant SNP sets associated with were derived from previous genome-wide association (GWAS). In total, 2,294 5,065 individuals BMD values different sites their genotype data obtained UK Biobank cohort. The PRS each...
Previous studies have revealed how single foods or nutrients affect dementia, but the evidence for a potential link between dietary diversity and dementia is inconsistent. This study aimed to evaluate association risk of incident dementia. prospective included 104,572 white participants without at baseline recruited 2006 2010 from UK Biobank. Dietary Diversity Score (DDS) was acquired through Oxford WebQ's 24-hour recall survey spanning 2009 2012. Cox proportional hazards models were used...
The genetic underpinnings of RA remain partially elucidated, motivating our exploration copy number variations (CNV) and rare in the pathogenesis RA. We conducted an integrated analysis genome-wide landscape CNV exome-wide variation associations with UK Biobank. To strengthen findings, we corroborated results by differentially expressed genes identified from gene expression profiles synovial tissue patients health controls. Furthermore, leveraged Drug-Gene Interaction Database to explore...
Abstract The aim of this study was to investigate the possible interaction mitochondrial dysfunction and inflammatory cytokines in risk anxiety depression. We utilized UK Biobank for sample study. A mitochondria-wide association(MiWAS) analysis performed effects DNA (mtDNA)×C-reactive protein (CRP) on risks self-reported ( N = 72,476), general disorder (GAD-7) scores 80,853), depression 80,778), Patient Health Questionnaire (PHQ-9) 80,520) total samples, females males, respectively,...
Osteoarthritis (OA) is the most prevalent joint disease. However, specific and definitive genetic mechanisms of OA are still unclear.Tissue-related transcriptome-wide association studies (TWAS) hip knee were performed utilizing genome-wide study (GWAS) data (including 2,396 hospital-diagnosed patients versus 9,593 controls, 4,462 17,885 controls) gene expression reference to skeletal muscle blood. The OA-associated genes identified by TWAS further compared with differentially expressed...
Abstract Background Herpes simplex virus‐1 (HSV‐1) infection is reported to be associated with depression. But limited efforts were made investigate the relationship between HSV‐1 and risk of depression, especially from genetic perspective. Methods In UK Biobank cohort, linear logistic regression analyses first performed test association seropositivity/antibody including depression status (N = 2951) Patient Health Questionnaire (PHQ) score 2839). Using individual genotypic phenotypic data...
Aims Despite the interest in association of gut microbiota with bone health, limited population-based studies and mineral density (BMD) have been made. Our aim is to explore possible between BMD. Methods A total 3,321 independent loci were used calculate individual polygenic risk score (PRS) for 114 microbiota-related traits. The genotype data obtained from UK Biobank cohort. Linear regressions then conducted evaluate L1-L4 BMD (n = 4,070), 4,056), femur 4,054), respectively. PLINK 2.0 was...
T-2 toxin and deoxynivalenol (DON) are two prevalent mycotoxins that cause cartilage damage in Kashin-Beck disease (KBD). Cartilage extracellular matrix (ECM) degradation chondrocytes is a significant pathological feature of KBD. It has been shown the Hippo pathway involved ECM degradation. This study aimed to examine effect YAP, major regulator pathway, on hiPS-derived (hiPS-Ch) model The hiPS-Ch injury models were established via treatment with toxin/DON alone or combination. We found DON...
Bone mineral density (BMD) is a major predictor of osteoporotic fractures, and previous studies have reported the effects mitochondrial dysfunction lifestyle on BMD, respectively. However, their interaction BMD are still unclear. Therefore, we aimed to investigate possible DNA (mtDNA) common lifestyles contributing osteoporosis.
Despite cumulative evidence showing obesity is associated with changes in sleep quality and quantity, the study about relationships between body composition scarce, whether relationship causal remains unknown. In this study, we examined there are associations composition.First, estimated genetic correlations sleep-related phenotypes using linkage disequilibrium score regression (LDSC). Mendelian randomization (MR) analysis was then conducted to test 2-way on significant associations....
Most previous genetic studies of sleep behaviors were conducted individually, without comprehensive consideration the complexity various behaviors. Our aim is to identify architecture and potential biomarker health score, which more powerfully represents overall traits.We a genome-wide association study (GWAS) score (overall assessment duration, snoring, insomnia, chronotype, daytime dozing) using 336,463 participants from UK Biobank. Proteome-wide (PWAS) transcriptome-wide (TWAS) then...