A5005368691- Gut microbiota and health
- Genetic Associations and Epidemiology
- Clostridium difficile and Clostridium perfringens research
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Sleep and related disorders
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Neuroscience of respiration and sleep
- Smoking Behavior and Cessation
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Magnesium Oxide Properties and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Circadian rhythm and melatonin
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Mycobacterium research and diagnosis
- Receptor Mechanisms and Signaling
- Viral Infections and Outbreaks Research
- Neurotransmitter Receptor Influence on Behavior
Guangdong Ocean University
2025
Tianjin University
2024
Xi'an Jiaotong University
2021-2024
National Health and Family Planning Commission
2021-2024
North China University of Science and Technology
2018-2024
Tianjin Medical University
2023-2024
Hunan Normal University
2023-2024
Huazhong University of Science and Technology
2023
Changsha Hospital for Maternal and Child Health Care
2023
University of Alberta
2014-2022
Abstract With the expansion of global population, energy shortage is becoming increasingly acute. Phase change materials (PCMs) are considered green and efficient mediums for thermal storage, but leakage problem caused by volume instability during phase limits their application. Encapsulating PCMs with supporting can effectively avoid leakage, most expensive consume huge natural resources. Carbon materials, which rich renewable resources, be used as economical environmentally friendly...
Aucubin (AU) is one of the main components traditional Chinese medicine Eucommia ulmoides Oliv (EU). This study investigated effects AU on aging-related skeletal muscle atrophy in vitro and vivo. The results network pharmacology revealed potential therapeutic atrophy. In vitro, effectively attenuated D-gal-induced cellular damage, reduced number senescence-associated β-galactosidase (SA-β-Gal)-positive cells, down-regulated expression levels atrophy-related proteins Atrogin-1 MuRF1, improved...
The ketogenic diet (KD) has been proposed as a potential treatment for depression. However, the underlying mechanisms remain poorly understood. This study aimed to evaluate further effects of KD...
Cumulative evidence shows that gut microbiome can influence brain function and behavior via the inflammatory processes. However, role of interaction between dysbiosis C-reactive protein (CRP) in development anxiety depression remains to be elucidated. In this study, a total 3321 independent single nucleotide polymorphism (SNP) loci associated with were driven from genome-wide association study (GWAS). Using individual level genotype data UK Biobank, we then calculated polygenetic risk...
Background Growing evidence supports that alterations in the gut microbiota play an essential role etiology of anxiety, depression, and other psychiatric disorders. However, potential effect oral on mental health has received little attention. Methods Using latest genome-wide association study (GWAS) summary data microbiome, polygenic risk scores (PRSs) 285 salivary microbiomes 309 tongue dorsum were conducted. Logistic linear regression models applied to evaluate relationship between...
Freak waves can cause serious damage to offshore structures because of their characteristics high peak energy, short duration, and great contingency. In this study, the slamming pressure a typical floating wind turbine under freak are studied by numerical simulation experiment. The computational fluid dynamics (CFD) method is used establish tank. experimental test float implemented at Jiangsu University Science Technology. model system modified based on an test. wave using model. combined...
Abstract The aim of this study was to investigate the possible interaction mitochondrial dysfunction and inflammatory cytokines in risk anxiety depression. We utilized UK Biobank for sample study. A mitochondria-wide association(MiWAS) analysis performed effects DNA (mtDNA)×C-reactive protein (CRP) on risks self-reported ( N = 72,476), general disorder (GAD-7) scores 80,853), depression 80,778), Patient Health Questionnaire (PHQ-9) 80,520) total samples, females males, respectively,...
Summary To facilitate investigation of diverse rodent behaviours in rodents’ home cages, we have developed an integrated modular platform, the S mart C age ™ system ( A fa ci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic analysis and vivo drug screening a relatively higher‐throughput more objective manner. The individual platform consists infrared array, vibration floor sensor variety devices. One computer can simultaneously operate up to 16 platforms via...
Previous studies have suggested that vitamin D (VD) was associated with psychiatric diseases, but efforts to elucidate the functional relevance of VD depression and anxiety from genetic perspective been limited. Based on UK Biobank cohort, we first calculated polygenic risk score (PRS) for genome-wide association study (GWAS) data VD. Linear logistic regression analysis were conducted evaluate associations traits traits, respectively. Then, using individual genotype phenotype Biobank,...
Despite cumulative evidence showing obesity is associated with changes in sleep quality and quantity, the study about relationships between body composition scarce, whether relationship causal remains unknown. In this study, we examined there are associations composition.First, estimated genetic correlations sleep-related phenotypes using linkage disequilibrium score regression (LDSC). Mendelian randomization (MR) analysis was then conducted to test 2-way on significant associations....
Most previous genetic studies of sleep behaviors were conducted individually, without comprehensive consideration the complexity various behaviors. Our aim is to identify architecture and potential biomarker health score, which more powerfully represents overall traits.We a genome-wide association study (GWAS) score (overall assessment duration, snoring, insomnia, chronotype, daytime dozing) using 336,463 participants from UK Biobank. Proteome-wide (PWAS) transcriptome-wide (TWAS) then...
The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, functions in allowing these cells to induce apoptosis virally-infected or transformed cells. Cancers of both lymphoid non-lymphoid origin also express GzB, some cases this expression has been linked pathogenesis sensitizing tumour cell death. For example, GzB urothelial carcinoma was implicated promoting invasion, whereas its nasal-type NK/T lymphomas found correlate with...
Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with GWAS dataset, respectively, to conduct a proteome-wide study (PWAS) analysis. Then transcriptome weights (Rnaseq Splicing) were applied transcriptome-wide (TWAS) Finally, PWAS TWAS results investigated...
As people age, their ability to regulate the body temperature gradually weakens. Old are always more vulnerable thermal-related discomfort in cold weather. The purpose of this paper was develop a smart heating clothing for elderly, which can automatically adjust underwear microclimate according different thermal condition. In our study, 8 elderly women were exposed cold, we have measured data skin temperatures and taken analysis on physiological characteristics. intelligent system developed...