A5101840312- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Apelin-related biomedical research
- MXene and MAX Phase Materials
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Angiogenesis and VEGF in Cancer
- Growth Hormone and Insulin-like Growth Factors
- Lipid metabolism and biosynthesis
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Cell death mechanisms and regulation
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- 2D Materials and Applications
- Sexual Differentiation and Disorders
- Ovarian function and disorders
- Hypothalamic control of reproductive hormones
- Wnt/β-catenin signaling in development and cancer
- Crystallization and Solubility Studies
Hubei Provincial Water Resources and Hydropower Planning Survey and Design Institute
2025
Yangtze River Pharmaceutical Group (China)
2024-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2013-2024
Xi'an Jiaotong University
2009-2023
First Hospital of Xi'an
2016
First Affiliated Hospital of Xi'an Jiaotong University
2007
Sulfur-containing gas reflects the internal operation of SF6 gas-insulated switchgear and is great importance for insulation fault diagnosis equipment. Based on density functional theory (DFT), several sulfur-containing gases are selected as target detection gases, Au-doped Ti3C2Tx MXene used sensing material to carry out adsorption simulation in this paper. These results suggest that O OH terminated Au@Ti3C2Tx have larger energies well charge transfer SO2 SOF2, furthermore, combined with...
The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with development comorbidities poor prognosis obesity. This study aims to evaluate interleukin-10 (IL-10) hypertriglyceridemia. We evaluated IL-10 signal transducer activator transcription 3 (STAT3) mRNA expression adipose tissue (AT) well serum 62 children groups high-fat diet (HFD) induced obese rat....
Abstract Context The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric deficiency (GHD) is limited. Objective This study aimed to examine the effectiveness and safety PEG-rhGH children with GHD real world, as well effects dose on patient outcomes. Design A prospective, observational, posttrial (NCT03290235). Setting, participants intervention Children were enrolled from 81 centers China 4 individual clinical trials received weekly 0.2 mg/kg/wk (high-dose)...
Summary Objective Secreted frizzled‐related protein 5 ( SFRP 5) is a novel anti‐inflammatory adipokine, which has been shown as mediator between obesity and its comorbidities. The aim of this study was to evaluate the associations with metabolic syndrome M et S ) effects lifestyle interventions on circulating levels in children. Design A cross‐sectional conducted among 111 obese children 49 lean controls, intervention performed subgroup 31 for 6 months. Anthropometric parameters, clinical...
There have been very few paediatric studies on omentin-1, an anti-inflammatory adipokine that provides a link between adiposity, insulin resistance and metabolic syndrome. This Chinese study evaluated the association omentin-1 syndrome analysed effect of six-month lifestyle intervention levels in obese children.We recruited 119 outpatients (75% boys) aged 7-18 years from Second Affiliated Hospital Xi'an Jiaotong University, who underwent six- month intervention. Our controls were 55 matched...
Abstract Epilepsy is a severe neurological condition affecting 50–65 million individuals worldwide that can lead to brain damage. Nevertheless, the etiology of epilepsy remains poorly understood. Meta-analyses genome-wide association studies involving 15,212 cases and 29,677 controls ILAE Consortium cohort were used conduct transcriptome-wide (TWAS) protein-wide (PWAS). Furthermore, protein-protein interaction (PPI) network was generated using STRING database, significant...
AIM:To investigate the inhibitory effect of As2O3 on angiogenesis tumor and expression vascular endothelial growth factor (VEGF) in cells vivo vitro . METHODS:The solid model was formed nude mice with gastric cancer cell line SGC-7901.The animals were randomly divided into three groups.As2O3 injected arsenic-treated groups (2.5 mg/kg 5 mg/kg) same volume saline solution control group.Microvessel density (MVD) VEGF detected immunofluorescence laser confocal technology.Further protein mRNA...
AIM:To investigate the effect of arsenic trioxide (As2O3) on expression vascular endothelial growth factor receptor-1 (VEGFR-1, Flt-1) and VEGFR-2 (KDR) in human gastric tumor cells proliferation cells. METHODS:The solid model was formed nude mice with cancer cell line SGC-7901.The animals were treated As2O3.Microvessel density (MVD) Flt-1 KDR detected by immunofluorescence laser confocal microscopy.SGC-7901 respectively exogenous recombinant VEGF165 or + As2O3.Cell viability measured MTT...
Metabolic syndrome (MetS) is the most common condition associated with childhood and adolescent obesity a challenging public health issue. Very few studies have described specificity sensitivity of serum levels adropin apelin-12 as predictors MetS. The aim this study was to evaluate association between MetS, their MetS in obese children.This involved 138 children. group included subjects two control groups without normal weight subjects. Anthropometric parameters clinical data were...
<b><i>Background:</i></b> Copeptin and nesfatin-1 have recently been identified as novel peptides that play a role in the pathogenesis of obesity-related insulin resistance adults. However, relationship between them has not yet elucidated, their circulating levels children with obesity adequately studied. Therefore, current study aimed to investigate whether are altered Chinese obesity, well determine correlation these 2 each other, resistance, other biochemical...
Objective Obesity is a metabolic disorder that can lead to high blood pressure, increased cholesterol and triglycerides, insulin resistance, diabetes mellitus. The aim was study the effects of pioglitazone mediated sensitization peroxisome proliferator-activated receptor gamma (PPAR-γ) on relationship Cell death-inducing DFFA-like effector C (CIDEC) with obesity related changes in mice. Methods Sixty C57B/L6 mice weighing 10–12g at 3 weeks age were randomly divided into groups. Mice Group 1...
Abstract Background To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature. Methods This real-world study enrolled children with stature in 19 hospitals throughout China. They were treated PEG-rhGH 6 months. The starting dosage ranged from 0.10 to 0.20 mg/kg/week. primary outcome was change height standard deviation score (ΔHt SDS). Results Five hundred and ten patients included grouped based on as A (0.10–0.14...
Purpose The aim of this study was to investigate the effect phosphotyrosine interaction domain containing 1 (PID1) on insulin-induced activation AKT (protein kinase B)/protein A (PKA)/hormone-sensitive lipase (HSL) pathway and lipolysis. Methods Sprague–Dawley rats were fed either chow or a high-fat diet (HFD). levels insulin, glycerol, free fatty acids (FFAs) PID1 mRNA expression measured in 2 groups. Furthermore, we examined role regulation AKT/PKA/HSL cascade lipolysis 3T3-L1 cell line....
AIM:To investigate the effect of arsenic trioxide (As2O3) on expression vascular endothelial growth factor receptor-1 (VEGFR-1, Flt-1) and VEGFR-2 (KDR) in human gastric tumor cells proliferation cells. METHODS:The solid model was formed nude mice with cancer cell line SGC-7901.The animals were treated As2O3.Microvessel density (MVD) Flt-1 KDR detected by immunofluorescence laser confocal microscopy.SGC-7901 respectively exogenous recombinant VEGF165 or + As2O3.Cell viability measured MTT...
We attempted to classify obese children with glucose abnormalities into different categories based on the plasma (PG) at 0, 60, 120 and 180 min extract metabolic information from shape of PG curve.We recruited 1205 325 nonobese children. Their body weight, blood pressure, waist hip circumferences were measured. An oral tolerance test (OGTT) was carried out, glucose, insulin glucagon levels tested.There six forms abnormal (AGT) curves in addition normal (NGT). 58.3% had AGT. BMI,...